PMID- 36453659
OWN - NLM
STAT- MEDLINE
DCOM- 20221202
LR  - 20230911
IS  - 1473-5598 (Electronic)
IS  - 0263-6352 (Print)
IS  - 0263-6352 (Linking)
VI  - 41
IP  - 1
DP  - 2023 Jan 1
TI  - Association of sodium intake with adverse left atrial function and left 
      atrioventricular coupling in Chinese.
PG  - 159-170
LID - 10.1097/HJH.0000000000003317 [doi]
AB  - OBJECTIVES: High sodium intake is strongly associated with hypertension and 
      obesity. This study aims to investigate the relationship between 24-h urinary 
      sodium (a surrogate measure of sodium intake), ambulatory blood pressure 
      parameters, left atrial function, and left atrioventricular coupling. Further, we 
      intend to examine whether blood pressure and BMI might be mediators of the 
      relationship between 24-h urinary sodium and subclinical cardiac function. 
      METHODS: Our study had 398 participants, all of whom were subjected to 24-h urine 
      collection, 24-h ambulatory blood pressure measurement, and cardiac magnetic 
      resonance imaging. RESULTS: The average age of the participants was 
      55.70 +/- 11.30 years old. The mean urinary sodium of the participants was 
      172.01 +/- 80.24 mmol/24 h. After adjusting for age, sex, history of diabetes, 
      smoking status, alcohol consumption, and use of diuretics, 24-h urinary sodium 
      was correlated with multiple ambulatory blood pressure parameters, BMI, left 
      atrial function, and the left atrioventricular coupling index (LACI) (P < 0.05). 
      Mediation analysis showed that BMI explained 16% of the indirect effect of 24-h 
      urinary sodium and left atrial function and 30% of the indirect effect of LACI. 
      Independent of the mediator, 24-h urinary sodium had a significant direct effect 
      on left atrial function and left atrioventricular coupling. CONCLUSIONS: Higher 
      24-h urinary sodium was associated with a greater BMI as well as poor left atrial 
      function and left atrioventricular coupling, and the BMI mediated the 
      relationship between 24-h urinary sodium and subclinical left cardiac function. 
      Furthermore, and more importantly, 24-h urinary sodium may have directly affected 
      the left atrial function and left atrioventricular coupling independent of 
      intermediary factors.
CI  - Copyright (c) 2022 The Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Yin, Lili
AU  - Yin L
AD  - Second Affiliated Hospital of Dalian Medical University.
FAU - Mei, Jiajie
AU  - Mei J
AD  - Second Affiliated Hospital of Dalian Medical University.
FAU - Dong, Jianli
AU  - Dong J
AD  - Second Affiliated Hospital of Dalian Medical University.
FAU - Qu, Xiaofeng
AU  - Qu X
AD  - Second Affiliated Hospital of Dalian Medical University.
FAU - Jiang, Yinong
AU  - Jiang Y
AD  - First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
LA  - eng
PT  - Journal Article
DEP - 20221107
PL  - Netherlands
TA  - J Hypertens
JT  - Journal of hypertension
JID - 8306882
RN  - 0 (Sodium-24)
RN  - 0 (Sodium Radioisotopes)
RN  - 0 (Sodium, Dietary)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - Aged
MH  - *Atrial Function, Left
MH  - Blood Pressure Monitoring, Ambulatory
MH  - Sodium Radioisotopes
MH  - *Sodium, Dietary
MH  - China
PMC - PMC9794161
COIS- There are no conflicts of interest.
EDAT- 2022/12/02 06:00
MHDA- 2022/12/03 06:00
PMCR- 2022/12/27
CRDT- 2022/12/01 07:22
PHST- 2022/12/01 07:22 [entrez]
PHST- 2022/12/02 06:00 [pubmed]
PHST- 2022/12/03 06:00 [medline]
PHST- 2022/12/27 00:00 [pmc-release]
AID - 00004872-202301000-00017 [pii]
AID - JH-D-22-00439 [pii]
AID - 10.1097/HJH.0000000000003317 [doi]
PST - ppublish
SO  - J Hypertens. 2023 Jan 1;41(1):159-170. doi: 10.1097/HJH.0000000000003317. Epub 
      2022 Nov 7.