PMID- 36454307
OWN - NLM
STAT- MEDLINE
DCOM- 20230628
LR  - 20230628
IS  - 1434-3916 (Electronic)
IS  - 0936-8051 (Linking)
VI  - 143
IP  - 7
DP  - 2023 Jul
TI  - The effect of topical tranexamic acid on functional outcomes and quality of life 
      in patients undergoing unicompartmental knee arthroplasty.
PG  - 4395-4400
LID - 10.1007/s00402-022-04711-y [doi]
AB  - INTRODUCTION: Tranexamic acid (TXA) is being increasingly utilized to reduce 
      blood loss after knee joint arthroplasty. However, there is a lack of studies on 
      the effect of topical TXA on the functional outcomes and quality of life after 
      Unicompartmental Knee Arthroplasty (UKA). The aim of this study was to determine 
      the effect of topical TXA on functional outcomes and quality of life scores in 
      patients undergoing UKA. MATERIALS AND METHODS: We retrospectively analysed 
      patients undergoing unilateral UKA at a single tertiary hospital from 2005 to 
      2017. Patients were divided into 2 groups: (1) The control group which did not 
      receive TXA (n = 742); (2) The TXA group which received topical TXA (n = 331). 
      Functional outcomes were assessed using the Knee Society Function Score (KSFS), 
      Knee Society Knee Score (KSKS) and Oxford Knee Score (OKS), while quality of life 
      was evaluated with the Physical Component Score (PCS) and Mental Component Score 
      (MCS) of Short-Form 36 (SF-36) preoperatively and at 6 months and 2 years 
      follow-up. RESULTS: At 6 months and 2 years post-surgery, there were no 
      significant differences in the functional scores between the groups. The number 
      of patients who attained minimum clinically important difference (MCID) for each 
      of the functional scores was also comparable between the groups. CONCLUSIONS: In 
      patients undergoing UKA, functional outcomes and quality of life scores were 
      comparable between those who received topical TXA and those who did not. There 
      was no significant improvement or impairment in knee function associated with 
      topical TXA administration in UKA up to 2 years follow-up.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Moorthy, Vikaesh
AU  - Moorthy V
AUID- ORCID: 0000-0002-5503-5687
AD  - Department of Orthopaedic Surgery, Singapore General Hospital, Block 6 Level 7, 
      Outram Road, Singapore, 169608, Singapore. vikaeshmoorthy@yahoo.com.
FAU - Chen, Jerry Yongqiang
AU  - Chen JY
AD  - Department of Orthopaedic Surgery, Singapore General Hospital, Block 6 Level 7, 
      Outram Road, Singapore, 169608, Singapore.
FAU - Liow, Ming Han Lincoln
AU  - Liow MHL
AD  - Department of Orthopaedic Surgery, Singapore General Hospital, Block 6 Level 7, 
      Outram Road, Singapore, 169608, Singapore.
FAU - Pang, Hee Nee
AU  - Pang HN
AD  - Department of Orthopaedic Surgery, Singapore General Hospital, Block 6 Level 7, 
      Outram Road, Singapore, 169608, Singapore.
FAU - Tay, Darren Keng-Jin
AU  - Tay DK
AD  - Department of Orthopaedic Surgery, Singapore General Hospital, Block 6 Level 7, 
      Outram Road, Singapore, 169608, Singapore.
FAU - Chia, Shi-Lu
AU  - Chia SL
AD  - Department of Orthopaedic Surgery, Singapore General Hospital, Block 6 Level 7, 
      Outram Road, Singapore, 169608, Singapore.
FAU - Lo, Ngai Nung
AU  - Lo NN
AD  - Department of Orthopaedic Surgery, Singapore General Hospital, Block 6 Level 7, 
      Outram Road, Singapore, 169608, Singapore.
FAU - Yeo, Seng Jin
AU  - Yeo SJ
AD  - Department of Orthopaedic Surgery, Singapore General Hospital, Block 6 Level 7, 
      Outram Road, Singapore, 169608, Singapore.
LA  - eng
GR  - 13/FY2017/P1/16-A30/FY2017 SingHealth DUKE-NUS Musculoskeletal Sciences Academic 
      Clinical Programme Research Support Programme Grant/
PT  - Journal Article
DEP - 20221201
PL  - Germany
TA  - Arch Orthop Trauma Surg
JT  - Archives of orthopaedic and trauma surgery
JID - 9011043
RN  - 6T84R30KC1 (Tranexamic Acid)
SB  - IM
MH  - Humans
MH  - *Arthroplasty, Replacement, Knee/adverse effects
MH  - *Tranexamic Acid
MH  - Treatment Outcome
MH  - Quality of Life
MH  - Retrospective Studies
MH  - Knee Joint/surgery
MH  - Administration, Topical
MH  - *Osteoarthritis, Knee/complications
OTO - NOTNLM
OT  - Arthroplasty
OT  - Functional outcome
OT  - Quality of life
OT  - Tranexamic acid
OT  - Unicompartmental knee arthroplasty
EDAT- 2022/12/02 06:00
MHDA- 2023/06/28 06:42
CRDT- 2022/12/01 11:15
PHST- 2022/08/03 00:00 [received]
PHST- 2022/11/22 00:00 [accepted]
PHST- 2023/06/28 06:42 [medline]
PHST- 2022/12/02 06:00 [pubmed]
PHST- 2022/12/01 11:15 [entrez]
AID - 10.1007/s00402-022-04711-y [pii]
AID - 10.1007/s00402-022-04711-y [doi]
PST - ppublish
SO  - Arch Orthop Trauma Surg. 2023 Jul;143(7):4395-4400. doi: 
      10.1007/s00402-022-04711-y. Epub 2022 Dec 1.