PMID- 36455796 OWN - NLM STAT- MEDLINE DCOM- 20230131 LR - 20230202 IS - 1535-6280 (Electronic) IS - 0146-2806 (Linking) VI - 48 IP - 3 DP - 2023 Mar TI - Delayed Ventricular Septal Rupture Repair on Patient Outcomes After Myocardial Infarction: A Systematic Review. PG - 101521 LID - S0146-2806(22)00418-2 [pii] LID - 10.1016/j.cpcardiol.2022.101521 [doi] AB - Even though the prevalence of VSR after MI is only 1%-3%, the mortality associated with the condition is more than 80%. Very few studies in the literature have described in detail the treatment options for delayed VSR repair. This systematic review was conducted to evaluate the outcomes of delayed ventricular septal rupture (VSR) repair following acute myocardial infarction (AMI). Digital databases were searched systematically to identify studies reporting the outcomes of delayed VSR repair. Detailed study and patient-level baseline characteristics including the type of study, sample size, follow-up, number of delayed repairs, time to repair, outcomes (in terms of major adverse cardiovascular events), and predictors of outcome were abstracted. A total of 12 studies, recruiting 8,579 patients were included in the final analysis. Male gender, young age (<60 years), and delayed VSR repair were reported as predictors of survival along with left ventricular assist devices (LVADs) and extracorporeal membrane oxygenation (ECMO), and the use of inotropes before surgery. Postoperative renal failure, higher New York Heart Association (NYHA) score, early repair, and history of heart failure (HF) were demonstrated as predictors of mortality. This study demonstrated that delayed VSR repair can reduce mortality in patients who develop VSR after AMI. Furthermore, the use of LVADs can prolong the time of surgery, and the use of inotropes can predict survival benefits in this patient cohort. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Rashid, Haroon AU - Rashid H AD - Department of Medicine, North Manchester General Hospital, Manchester, UK. FAU - Kumar, Kantash AU - Kumar K AD - Department of Medicine, Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan. FAU - Ullah, Asif AU - Ullah A AD - Department of Cardiology, Khyber Medical University Institute of Medical Sciences, Kohat, Pakistan. FAU - Kamin, Matiullah AU - Kamin M AD - Department of Endocrinology, Bolan Medical University, and Health Sciences, Quetta, Pakistan. FAU - Shafique, Hafiz Muhammad AU - Shafique HM AD - Department of Interventional Cardiology, Armed Forces Institute of Cardiology, Rawalpindi, Pakistan. FAU - Elahi, Azaan AU - Elahi A AD - Department of Medicine, Shifa International Hospital, Islamabad, Pakistan. FAU - Najam, Ali AU - Najam A AD - Department of Medicine, Shifa International Hospital, Islamabad, Pakistan. FAU - Zaidi, Syed Muhammad Jawad AU - Zaidi SMJ AD - Cardiovascular Analytics Group, Hong Kong, China. FAU - Asad, Muhammad AU - Asad M AD - Department of Cardiology, Benazir Bhutto Hospital, Rawalpindi, Pakistan. FAU - Mahmoodi, Amin AU - Mahmoodi A AD - Department of Medicine, Ibn e Seena Hospital, Kabul, Afghanistan. FAU - Malik, Jahanzeb AU - Malik J AD - Cardiovascular Analytics Group, Hong Kong, China. Electronic address: heartdoc86@gmail.com. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20221128 PL - Netherlands TA - Curr Probl Cardiol JT - Current problems in cardiology JID - 7701802 SB - IM MH - Humans MH - Male MH - Middle Aged MH - *Ventricular Septal Rupture/epidemiology/etiology/surgery MH - Treatment Outcome MH - Risk Factors MH - Retrospective Studies MH - *Myocardial Infarction/surgery EDAT- 2022/12/02 06:00 MHDA- 2023/02/01 06:00 CRDT- 2022/12/01 19:26 PHST- 2022/11/18 00:00 [received] PHST- 2022/11/25 00:00 [accepted] PHST- 2022/12/02 06:00 [pubmed] PHST- 2023/02/01 06:00 [medline] PHST- 2022/12/01 19:26 [entrez] AID - S0146-2806(22)00418-2 [pii] AID - 10.1016/j.cpcardiol.2022.101521 [doi] PST - ppublish SO - Curr Probl Cardiol. 2023 Mar;48(3):101521. doi: 10.1016/j.cpcardiol.2022.101521. Epub 2022 Nov 28.