PMID- 36456139
OWN - NLM
STAT- MEDLINE
DCOM- 20221205
LR  - 20221205
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 42
IP  - 12
DP  - 2022 Dec
TI  - The Expression of Histone Acetyltransferase KAT6A in Non-small Cell Lung Cancer.
PG  - 5731-5741
LID - 10.21873/anticanres.16080 [doi]
AB  - BACKGROUND/AIM: KAT6A is considered a factor influencing carcinogenesis. Due to 
      the fact that lung cancer is one of the leading causes of death, the aim of our 
      study was to evaluate KAT6A expression in non-small cell lung cancer (NSCLC) 
      tumors and the NSCLC cell line model. MATERIALS AND METHODS: The expression of 
      KAT6A was examined in NSCLC tumors by real-time PCR and immunohistochemistry. 
      KAT6A expression was investigated in the NSCLC cell line model by real-time PCR, 
      western blot, and immunofluorescence. RESULTS: KAT6A protein level was elevated 
      in NSCLC tumors compared to non-malignant lung tissues (NMLT). The KAT6A mRNA 
      expression in NSCLC, lung adenocarcinoma, and lung squamous cell carcinoma 
      samples was differentiated. The results from the in vitro NSCLC model 
      demonstrated elevated expression of KAT6A in lung cancer cell lines in comparison 
      to normal lung fibroblasts. CONCLUSION: The outcomes showed an increased KAT6A 
      protein level in NSCLC compared to control samples, which suggests the oncogenic 
      role of KAT6A in this type of cancer. Therefore, targeting KAT6A in NSCLC might 
      be worth consideration.
CI  - Copyright (c) 2022 International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Partynska, Aleksandra
AU  - Partynska A
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland; 
      aleksandra.partynska@umw.edu.pl.
FAU - Piotrowska, Aleksandra
AU  - Piotrowska A
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
FAU - Pawelczyk, Konrad
AU  - Pawelczyk K
AD  - Lower Silesian Oncology, Pulmonology and Haematology Centre, Wroclaw, Poland.
FAU - Rzechonek, Adam
AU  - Rzechonek A
AD  - Department of Thoracic Surgery, Wroclaw Medical University, Wroclaw, Poland.
FAU - Ratajczak-Wielgomas, Katarzyna
AU  - Ratajczak-Wielgomas K
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
FAU - Podhorska-Okolow, Marzenna
AU  - Podhorska-Okolow M
AD  - Division of Ultrastructural Research, Faculty of Medicine, Wroclaw Medical 
      University, Wroclaw, Poland.
AD  - Division of Human Biology, Faculty of Physiotherapy, Wroclaw University of Health 
      and Sport Sciences, Wroclaw, Poland.
FAU - Dziegiel, Piotr
AU  - Dziegiel P
AD  - Division of Histology and Embryology, Department of Human Morphology and 
      Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
AD  - Division of Human Biology, Faculty of Physiotherapy, Wroclaw University of Health 
      and Sport Sciences, Wroclaw, Poland.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - EC 2.3.1.48 (Histone Acetyltransferases)
RN  - EC 2.3.1.48 (KAT6A protein, human)
SB  - IM
MH  - Humans
MH  - *Carcinoma, Non-Small-Cell Lung/genetics
MH  - *Lung Neoplasms/genetics
MH  - Histone Acetyltransferases/genetics
MH  - *Adenocarcinoma of Lung
MH  - Oncogenes
MH  - Carcinogenesis
OTO - NOTNLM
OT  - KAT6A
OT  - lysine acetyltransferase
OT  - non-small cell lung cancer
EDAT- 2022/12/02 06:00
MHDA- 2022/12/06 06:00
CRDT- 2022/12/01 21:13
PHST- 2022/09/27 00:00 [received]
PHST- 2022/10/11 00:00 [revised]
PHST- 2022/10/12 00:00 [accepted]
PHST- 2022/12/01 21:13 [entrez]
PHST- 2022/12/02 06:00 [pubmed]
PHST- 2022/12/06 06:00 [medline]
AID - 42/12/5731 [pii]
AID - 10.21873/anticanres.16080 [doi]
PST - ppublish
SO  - Anticancer Res. 2022 Dec;42(12):5731-5741. doi: 10.21873/anticanres.16080.