PMID- 36457111
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221212
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 14
IP  - 1
DP  - 2022 Dec 2
TI  - Fibrinogen function indexes are potential biomarkers for evaluating the 
      occurrence and severity of diabetic foot.
PG  - 182
LID - 10.1186/s13098-022-00960-4 [doi]
LID - 182
AB  - BACKGROUND AND OBJECTIVES: Research suggests that fibrinogen (Fib) concentrations 
      are used to assess the occurrence and severity of diabetic foot (DF) and to 
      monitor the progression of diabetic foot in patients. However, its correlation 
      with Fib function has not been reported. Here, angle alpha and k value, reflecting 
      the Fib function, were used to analyse its correlation with DF, and their 
      potential as biological indicators for evaluating the occurrence and severity of 
      DF was explored. SUBJECTS AND METHODS: This clinical study enrolled 163 type 2 
      diabetes mellitus (T2DM) patients, who were divided into the diabetes with DF (84 
      cases) group, diabetes with no DF (79 cases) group. Meanwhile, 90 healthy 
      unrelated subjects were enrolled as controls. RESULTS: Angle alpha and fibrinogen 
      levels increased greatly in subjects with DF compared with those without. The k 
      value levels greatly decreased in subjects with DF compared with those without 
      (P < 0.01). Spearman correlation analysis showed that angle alpha and fibrinogen were 
      positively correlated with DF grading (r = 0.635, P < 0.01; r = 0.616, P < 0.01), 
      k value was negatively correlated with DF (r= - 0.589, P < 0.01). ROC curve 
      analysis showed that the optimal cut-off point for angle alpha to distinguish 
      patients with DF from those without was 62.85 deg, with a sensitivity of 78.6% 
      and specificity of 78.7%. The optimal cut-off point for k value was 1.75 min, 
      with a sensitivity of 82.1% and specificity of 65.8%. The optimal cut-off point 
      for fibrinogen was 3.85 g/l, with a sensitivity of 63.1% and specificity of 
      98.2%. The optimal cut-off point for angle alpha to evaluate the risk of diabetic 
      foot progression was 70.20 deg, with a sensitivity of 73.2% and specificity of 
      90.7%. The optimal cut-off point for k value was 1.25 min, with a sensitivity of 
      67.9% and specificity of 90.8%. The optimal cut-off point for fibrinogen was 
      4.12 g/l, with a sensitivity of 85.7% and specificity of 93.5%. CONCLUSION: Angle 
      alpha, k-value and fibrinogen have clinical significance on the risk of occurrence 
      and development of diabetic foot, which can contribute to early diagnosis and 
      early clinical intervention in DF.
CI  - (c) 2022. The Author(s).
FAU - Zhang, Jinying
AU  - Zhang J
AD  - Department of Neurology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, 362000, Fujian, China.
FAU - Lin, Jiayu
AU  - Lin J
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, No. 950 Donghai Street, Fengze District, Quanzhou, 362000, Fujian, 
      China. 415794814@qq.com.
FAU - Liang, Bo
AU  - Liang B
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, No. 950 Donghai Street, Fengze District, Quanzhou, 362000, Fujian, 
      China.
FAU - Chen, Lijun
AU  - Chen L
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, No. 950 Donghai Street, Fengze District, Quanzhou, 362000, Fujian, 
      China.
FAU - Yang, Xinna
AU  - Yang X
AD  - Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical 
      University, No. 950 Donghai Street, Fengze District, Quanzhou, 362000, Fujian, 
      China.
FAU - Li, Mimi
AU  - Li M
AD  - Department of Neurology, The Second Affiliated Hospital of Fujian Medical 
      University, Quanzhou, 362000, Fujian, China.
LA  - eng
GR  - 2020QH1122/the Startup Fund for scientific research, Fujian Medical University/
GR  - 2018QH1105/the Startup Fund for scientific research, Fujian Medical University/
GR  - 2021TG014/Fujian provincial health technology project/
GR  - 2019-1-54/Fujian provincial health technology project/
PT  - Journal Article
DEP - 20221202
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC9717543
OTO - NOTNLM
OT  - Angle alpha
OT  - Diabetic foot
OT  - Fibrinogen
OT  - K value
OT  - Wagner classification
COIS- No potential conflicts of interest relevant to this article were reported.
EDAT- 2022/12/03 06:00
MHDA- 2022/12/03 06:01
PMCR- 2022/12/02
CRDT- 2022/12/02 00:10
PHST- 2022/04/13 00:00 [received]
PHST- 2022/11/26 00:00 [accepted]
PHST- 2022/12/02 00:10 [entrez]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/03 06:01 [medline]
PHST- 2022/12/02 00:00 [pmc-release]
AID - 10.1186/s13098-022-00960-4 [pii]
AID - 960 [pii]
AID - 10.1186/s13098-022-00960-4 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2022 Dec 2;14(1):182. doi: 10.1186/s13098-022-00960-4.