PMID- 36458098
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221203
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 30
IP  - 1
DP  - 2023 Jan
TI  - Hepatoprotective effect of pinostrobin against thioacetamide-induced liver 
      cirrhosis in rats.
PG  - 103506
LID - 10.1016/j.sjbs.2022.103506 [doi]
LID - 103506
AB  - The study in vivo assessed the effect of pinostrobin on the histology, 
      immunohistochemistry, and biochemical parameters of thioacetamide (TAA) induced 
      liver cirrhosis in Sprague Dawley rats. The rats were noticeably gavaged with two 
      doses of pinostrobin (30 mg/kg and 60 mg/kg) with TAA and exhibited a substantial 
      decrease in the liver index and hepatocyte propagation with much minor cell 
      injury. These groups meaningfully down-regulated the proliferation of cellular 
      nucleus antigen (PCNA) and alpha-smooth muscle actin (alpha-SMA). The liver 
      homogenate displayed augmented antioxidant enzymes, superoxide dismutase (SOD) 
      and catalase (CAT) activities escorted with reducing in malondialdehyde (MDA) 
      level. The serum level of bilirubin, total protein, albumin, and liver enzymes 
      (ALP, ALT, and AST) returned to normal and was similar to that of normal control 
      and silymarin with TAA-treated groups. pinostrobin-fed groups also decreased the 
      level of Tumor necrosis factor-alpha (TNF-alpha), Interleukin-6 (IL-6), and increased 
      the level of Interleukin-10 (IL-10). Acute toxicity with a higher dose of 
      500 mg/kg of pinostrobin did not manifest any toxicological signs in rats. The 
      hepatoprotective effect of pinostrobin could be due to potentially inhibited the 
      progression of liver cirrhosis, down-regulation of PCNA and alpha-SMA proliferation, 
      prevented oxidation of hepatocytes, improved SOD and CAT enzymes, condensed MDA, 
      repairs of liver biomarkers, reduced cellular inflammation and modulation of 
      inflammatory cytokines.
CI  - (c) 2022 The Author(s).
FAU - Shareef, Suhayla H
AU  - Shareef SH
AD  - Department of Biology, College of Education, Salahaddin University-Erbil, Erbil, 
      Kurdistan Region, Iraq.
FAU - Al-Medhtiy, Morteta H
AU  - Al-Medhtiy MH
AD  - Department of Anatomy and Histology, Faculty of Veterinary Medicine, University 
      of Kufa, Iraq.
FAU - Al Rashdi, Ahmed S
AU  - Al Rashdi AS
AD  - Central Public Health Laboratories, Ministry of Health, Oman.
FAU - Aziz, Peshawa Y
AU  - Aziz PY
AD  - Department of Medical Laboratory Science, Technical College of Applied Science, 
      Sulaimani Polytechnic University, Sulaymaniyah, Kurdistan Region, Iraq.
FAU - Abdulla, Mahmood A
AU  - Abdulla MA
AD  - Department of Medical Microbiology, College of Science, Cihan University-Erbil, 
      Erbil, Kurdistan Region, Iraq.
LA  - eng
PT  - Journal Article
DEP - 20221117
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC9706172
OTO - NOTNLM
OT  - Histology
OT  - IL-10
OT  - IL-6
OT  - Liver cirrhosis
OT  - Liver function tests
OT  - PCNA
OT  - Pinostrobin
OT  - TAA
OT  - TNF-alpha
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/12/03 06:00
MHDA- 2022/12/03 06:01
PMCR- 2022/11/17
CRDT- 2022/12/02 02:35
PHST- 2022/06/14 00:00 [received]
PHST- 2022/10/23 00:00 [revised]
PHST- 2022/11/11 00:00 [accepted]
PHST- 2022/12/02 02:35 [entrez]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/03 06:01 [medline]
PHST- 2022/11/17 00:00 [pmc-release]
AID - S1319-562X(22)00422-3 [pii]
AID - 103506 [pii]
AID - 10.1016/j.sjbs.2022.103506 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2023 Jan;30(1):103506. doi: 10.1016/j.sjbs.2022.103506. Epub 
      2022 Nov 17.