PMID- 36458119
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221203
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 13
DP  - 2022
TI  - Effect of online aerobic exercise training in patients with bipolar depression: 
      Protocol of a randomized clinical trial.
PG  - 1011978
LID - 10.3389/fpsyt.2022.1011978 [doi]
LID - 1011978
AB  - INTRODUCTION: Bipolar disorder (BD) is a common and debilitating mental illness 
      that affects about 400 million people worldwide, decreasing their functionality 
      and quality of life. Medication and psychotherapy are recommended for treatment 
      of BD, while some evidence indicates that exercise could improve the clinical 
      outcome of BD. This study aims to investigate whether exercise intervention could 
      reduce the mood symptoms and inflammation level of BD. METHODS: This is a 
      longitudinal, interventional, randomized, and single-blind trial. We plan to 
      recruit 94 patients diagnosed with BD in depression episode. Patients will be 
      randomly assigned to treatment as usual + aerobic exercise group (intervention 
      group) and treatment as usual (TAU) only group, at a ratio of 1:1. The 
      intervention group will undergo 40-min aerobic exercise training twice a week for 
      eight weeks. The primary outcome of this study is the mean change of Hamilton 
      Depression Rating Scale 17 (HAMD 17) scores from baseline to week 8. The Young 
      Manic Rating Scale (YMRS), Self-Rating Depression Scale (SDS), and Interleukin-6 
      (IL-6), Tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP) levels will 
      also be measured. The measurements will be performed at baseline, immediately 
      after intervention and two months after intervention. DISCUSSION: Aerobic 
      exercise training + treatment is expected to bring more benefits to BD patients 
      than TAU only. This trial might provide stronger evidence of physical exercise 
      efficacy for BD treatment. CLINICAL TRIAL REGISTRATION: This study was approved 
      by the Chinese Clinical Trial Registry (Registration Code: ChiCTR2200057159). 
      Registered on 1 March 2022.
CI  - Copyright (c) 2022 Wang, Luo, Zhang, Mao, Lu, Zhang, Jiang and Luo.
FAU - Wang, Xueqian
AU  - Wang X
AD  - Department of Psychiatry, First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Luo, Huirong
AU  - Luo H
AD  - Department of Psychiatry, First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Zhang, Yinlin
AU  - Zhang Y
AD  - Department of Psychiatry, First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Mao, Maolin
AU  - Mao M
AD  - Department of Psychiatry, First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Lu, Yulin
AU  - Lu Y
AD  - Department of Psychiatry, Banan People's Hospital of Chongqing, Chongqing, China.
FAU - Zhang, Zheng
AU  - Zhang Z
AD  - Department of Psychiatry, First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Jiang, Chunfeng
AU  - Jiang C
AD  - Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
FAU - Luo, Qinghua
AU  - Luo Q
AD  - Department of Psychiatry, First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20221109
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC9705266
OTO - NOTNLM
OT  - aerobic exercise
OT  - bipolar depression
OT  - online intervention program
OT  - physical activity
OT  - pro-inflammatory cytokines
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/03 06:00
MHDA- 2022/12/03 06:01
PMCR- 2022/11/09
CRDT- 2022/12/02 02:36
PHST- 2022/08/04 00:00 [received]
PHST- 2022/10/21 00:00 [accepted]
PHST- 2022/12/02 02:36 [entrez]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/03 06:01 [medline]
PHST- 2022/11/09 00:00 [pmc-release]
AID - 10.3389/fpsyt.2022.1011978 [doi]
PST - epublish
SO  - Front Psychiatry. 2022 Nov 9;13:1011978. doi: 10.3389/fpsyt.2022.1011978. 
      eCollection 2022.