PMID- 36458159
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230404
IS  - 2296-2646 (Print)
IS  - 2296-2646 (Electronic)
IS  - 2296-2646 (Linking)
VI  - 10
DP  - 2022
TI  - Contactless and robust dielectric microspheres-assisted surface-enhanced Raman 
      scattering sensitivity improvement for anthrax biomarker detection.
PG  - 1057241
LID - 10.3389/fchem.2022.1057241 [doi]
LID - 1057241
AB  - This report presents a contactless and robust dielectric microspheres 
      (DMs)-assisted surface enhanced Raman scattering (SERS) enhancement method to 
      improve SERS detection sensitivity detection sensitivity. DMs that could focus 
      and collect light were embedded within the polydimethylsiloxane (PDMS) film to 
      avoid direct contact with the analytical solution and improve detection 
      reliability. The as prepared DMs embedded PDMS (DMs-PDMS) film was integrated 
      with a microfluidic technique to enhance the SERS signal of a liquid substrate. 
      Detection in microfluidic systems can reduce reagent consumption, shorten assay 
      time, and avoid evaporation of the colloid substrate solution. The robustness and 
      potential influencing factors of DMs-PDMS film assisted SERS enhancement (DERS) 
      were evaluated using 4-aminothiophenol (4-ATP) as the Raman probe. The sensing 
      performance of the proposed method toward dipicolinic acid (DPA) was evaluated, 
      and an evident signal intensification was obtained. Remarkably, the DMs-PDMS film 
      can also be implemented on solid substrates. A proof-of-concept experiment was 
      performed by covering the DMs-PDMS film directly over an AgNPs@Si solid substrate 
      wherein a 5.7-fold sensitivity improvement was achieved.
CI  - Copyright (c) 2022 Ge, Zhao, Han, Gai and Zong.
FAU - Ge, Mengyi
AU  - Ge M
AD  - School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, 
      Jiangsu, China.
FAU - Zhao, Wenfeng
AU  - Zhao W
AD  - School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, 
      Jiangsu, China.
FAU - Han, Yue
AU  - Han Y
AD  - School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, 
      Jiangsu, China.
FAU - Gai, Hongwei
AU  - Gai H
AD  - School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, 
      Jiangsu, China.
FAU - Zong, Chenghua
AU  - Zong C
AD  - School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou, 
      Jiangsu, China.
LA  - eng
PT  - Journal Article
DEP - 20221115
PL  - Switzerland
TA  - Front Chem
JT  - Frontiers in chemistry
JID - 101627988
EIN - Front Chem. 2023 Mar 09;11:1161985. PMID: 36970410
PMC - PMC9705956
OTO - NOTNLM
OT  - detection
OT  - dielectric microsphere
OT  - dipicolinic acid
OT  - polydimethylsiloxane (PDMS)
OT  - surface-enhanced Raman scattering
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/03 06:00
MHDA- 2022/12/03 06:01
PMCR- 2022/01/01
CRDT- 2022/12/02 02:37
PHST- 2022/09/29 00:00 [received]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2022/12/02 02:37 [entrez]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/03 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 1057241 [pii]
AID - 10.3389/fchem.2022.1057241 [doi]
PST - epublish
SO  - Front Chem. 2022 Nov 15;10:1057241. doi: 10.3389/fchem.2022.1057241. eCollection 
      2022.