PMID- 36458570
OWN - NLM
STAT- MEDLINE
DCOM- 20221222
LR  - 20221227
IS  - 2222-1751 (Electronic)
IS  - 2222-1751 (Linking)
VI  - 12
IP  - 1
DP  - 2023 Dec
TI  - Place of magistral preparations to continue the treatment if the drug is 
      commercially stopped worldwide? A case report of a 10-year-old child with 
      subacute sclerosing panencephalitis (SSPE) requiring inosiplex.
PG  - 2148563
LID - 10.1080/22221751.2022.2148563 [doi]
LID - 2148563
AB  - Subacute sclerosing panencephalitis (SSPE) is a late-onset and fatal viral 
      disease caused by persistent infection of the central nervous system by measles 
      virus (MeV). We present the case of a 10-year-old child from South Asia affected 
      by SSPE, stabilized with a combination of intrathecal interferon-alpha2b (INF-alpha2b) 
      injections and oral inosiplex and how we continued the treatment when inosiplex 
      was commercially stopped worldwide.
FAU - Le Cras, Renan
AU  - Le Cras R
AD  - Pharmacy Department, Grenoble University Hospital, Grenoble, France.
FAU - Mazet, Roseline
AU  - Mazet R
AUID- ORCID: 0000-0002-1841-6691
AD  - Pharmacy Department, Grenoble University Hospital, Grenoble, France.
FAU - Dubois-Teklali, Fanny
AU  - Dubois-Teklali F
AUID- ORCID: 0000-0002-4057-2375
AD  - Pediatric Neurology Unit, Grenoble University Hospital, Grenoble, France.
FAU - Sabourdy, Cecile
AU  - Sabourdy C
AUID- ORCID: 0000-0002-6781-9761
AD  - Neurology Unit, Grenoble University Hospital, Grenoble, France.
FAU - Chanoine, Sebastien
AU  - Chanoine S
AUID- ORCID: 0000-0001-7708-9777
AD  - Pharmacy Department, Grenoble University Hospital, Grenoble, France.
AD  - Universite Grenoble Alpes TIMC, CNRS UMR 5525, Grenoble, France.
FAU - Lehmann, Audrey
AU  - Lehmann A
AUID- ORCID: 0000-0003-4237-4329
AD  - Pharmacy Department, Grenoble University Hospital, Grenoble, France.
FAU - Morin, Agathe
AU  - Morin A
AD  - Pharmacy Department, Grenoble University Hospital, Grenoble, France.
FAU - Leenhardt, Julien
AU  - Leenhardt J
AD  - Pharmacy Department, Grenoble University Hospital, Grenoble, France.
AD  - Universite Grenoble Alpes, INSERM, LRB, Grenoble, France.
FAU - Durand, Marjorie
AU  - Durand M
AD  - Pharmacy Department, Grenoble University Hospital, Grenoble, France.
FAU - Desruet, Marie-Dominique
AU  - Desruet MD
AD  - Pharmacy Department, Grenoble University Hospital, Grenoble, France.
FAU - Bedouch, Pierrick
AU  - Bedouch P
AUID- ORCID: 0000-0003-2245-0160
AD  - Pharmacy Department, Grenoble University Hospital, Grenoble, France.
AD  - Universite Grenoble Alpes TIMC, CNRS UMR 5525, Grenoble, France.
LA  - eng
PT  - Case Reports
PT  - Letter
PL  - United States
TA  - Emerg Microbes Infect
JT  - Emerging microbes & infections
JID - 101594885
RN  - W1SO0V223F (Inosine Pranobex)
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - Humans
MH  - Child
MH  - *Inosine Pranobex/therapeutic use
MH  - *Subacute Sclerosing Panencephalitis/drug therapy
MH  - Interferon-alpha/therapeutic use
MH  - Asia, Southern
PMC - PMC9788679
OTO - NOTNLM
OT  - Inosiplex
OT  - inosine pranobex
OT  - magistral preparation
OT  - speciality commercially stopped
OT  - subacute sclerosing panencephalitis (SSPE)
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2022/12/03 06:00
MHDA- 2022/12/23 06:00
PMCR- 2022/12/20
CRDT- 2022/12/02 05:22
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/23 06:00 [medline]
PHST- 2022/12/02 05:22 [entrez]
PHST- 2022/12/20 00:00 [pmc-release]
AID - 2148563 [pii]
AID - 10.1080/22221751.2022.2148563 [doi]
PST - ppublish
SO  - Emerg Microbes Infect. 2023 Dec;12(1):2148563. doi: 
      10.1080/22221751.2022.2148563.