PMID- 36458881
OWN - NLM
STAT- MEDLINE
DCOM- 20230414
LR  - 20231203
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 108
IP  - 5
DP  - 2023 Apr 13
TI  - Association of Longitudinal Activity Measures and Diabetes Risk: An Analysis From 
      the National Institutes of Health All of Us Research Program.
PG  - 1101-1109
LID - 10.1210/clinem/dgac695 [doi]
AB  - CONTEXT: Prior studies of the relationship between physical activity and incident 
      type 2 diabetes mellitus (T2DM) relied primarily on questionnaires at a single 
      time point. OBJECTIVE: We sought to investigate the relationship between physical 
      activity and incident T2DM with an innovative approach using data from commercial 
      wearable devices linked to electronic health records in a real-world population. 
      METHODS: Using All of Us participants' accelerometer data from their personal 
      Fitbit devices, we used a time-varying Cox proportional hazards models with 
      repeated measures of physical activity for the outcome of incident T2DM. We 
      evaluated for effect modification with age, sex, body mass index (BMI), and 
      sedentary time using multiplicative interaction terms. RESULTS: From 5677 
      participants in the All of Us Research Program (median age 51 years; 74% female; 
      89% White), there were 97 (2%) cases of incident T2DM over a median follow-up 
      period of 3.8 years between 2010 to 2021. In models adjusted for age, sex, and 
      race, the hazard of incident diabetes was reduced by 44% (95% CI, 15%-63%; P = 
      0.01) when comparing those with an average daily step count of 10 700 to those 
      with 6000. Similar benefits were seen comparing groups based on average duration 
      of various intensities of activity (eg, lightly active, fairly active, very 
      active). There was no evidence for effect modification by age, sex, BMI, or 
      sedentary time. CONCLUSION: Greater time in any type of physical activity 
      intensity was associated with lower risk of T2DM irrespective of age, sex, BMI, 
      or sedentary time.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Perry, Andrew S
AU  - Perry AS
AUID- ORCID: 0000-0003-3342-6158
AD  - Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt 
      University School of Medicine, Nashville, TN 37203, USA.
FAU - Annis, Jeffrey S
AU  - Annis JS
AD  - Vanderbilt Institute for Clinical and Translational Research, Vanderbilt 
      University School of Medicine, Nashville, TN 37203, USA.
FAU - Master, Hiral
AU  - Master H
AUID- ORCID: 0000-0003-0019-3087
AD  - Vanderbilt Institute for Clinical and Translational Research, Vanderbilt 
      University School of Medicine, Nashville, TN 37203, USA.
FAU - Nayor, Matthew
AU  - Nayor M
AUID- ORCID: 0000-0002-6993-9396
AD  - Sections of Cardiovascular Medicine and Preventive Medicine and Epidemiology, 
      Department of Medicine, Boston University School of Medicine, Boston, MA 02118, 
      USA.
FAU - Hughes, Andrew
AU  - Hughes A
AUID- ORCID: 0000-0002-9592-5916
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 
      37203, USA.
FAU - Kouame, Aymone
AU  - Kouame A
AD  - Vanderbilt Institute for Clinical and Translational Research, Vanderbilt 
      University School of Medicine, Nashville, TN 37203, USA.
FAU - Natarajan, Karthik
AU  - Natarajan K
AUID- ORCID: 0000-0002-9066-9431
AD  - Department of Biomedical Informatics, Columbia University, New York, NY 10032, 
      USA.
FAU - Marginean, Kayla
AU  - Marginean K
AD  - Vanderbilt Institute for Clinical and Translational Research, Vanderbilt 
      University School of Medicine, Nashville, TN 37203, USA.
FAU - Murthy, Venkatesh
AU  - Murthy V
AUID- ORCID: 0000-0002-7901-1321
AD  - Department of Medicine and Radiology, University of Michigan, Ann Arbor, MI 
      48109, USA.
FAU - Roden, Dan M
AU  - Roden DM
AUID- ORCID: 0000-0002-6302-0389
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 
      37203, USA.
AD  - Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 
      37203, USA.
AD  - Department of Biomedical Informatics, Vanderbilt University Medical Center, 
      Nashville, TN 37203, USA.
FAU - Harris, Paul A
AU  - Harris PA
AUID- ORCID: 0000-0002-1744-2011
AD  - Vanderbilt Institute for Clinical and Translational Research, Vanderbilt 
      University School of Medicine, Nashville, TN 37203, USA.
AD  - Department of Biomedical Informatics, Vanderbilt University Medical Center, 
      Nashville, TN 37203, USA.
AD  - Department of Biomedical Engineering, Vanderbilt University Medical Center, 
      Nashville, TN 37203, USA.
FAU - Shah, Ravi
AU  - Shah R
AUID- ORCID: 0000-0002-4471-7156
AD  - Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt 
      University School of Medicine, Nashville, TN 37203, USA.
FAU - Brittain, Evan L
AU  - Brittain EL
AUID- ORCID: 0000-0001-5843-3392
AD  - Vanderbilt Translational and Clinical Cardiovascular Research Center, Vanderbilt 
      University School of Medicine, Nashville, TN 37203, USA.
LA  - eng
GR  - R38 HL167237/HL/NHLBI NIH HHS/United States
GR  - R01 HL131029/HL/NHLBI NIH HHS/United States
GR  - R01 HL156975/HL/NHLBI NIH HHS/United States
GR  - R01 HL146588/HL/NHLBI NIH HHS/United States
GR  - R01 DK124845/DK/NIDDK NIH HHS/United States
GR  - K23 HL138260/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Male
MH  - United States/epidemiology
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Risk Factors
MH  - *Population Health
MH  - Body Mass Index
MH  - National Institutes of Health (U.S.)
MH  - Incidence
PMC - PMC10306083
OTO - NOTNLM
OT  - activity monitoring
OT  - diabetes
OT  - physical activity
OT  - risk factors
EDAT- 2022/12/03 06:00
MHDA- 2023/04/14 06:41
PMCR- 2023/12/02
CRDT- 2022/12/02 08:43
PHST- 2022/10/04 00:00 [received]
PHST- 2023/04/14 06:41 [medline]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/02 08:43 [entrez]
PHST- 2023/12/02 00:00 [pmc-release]
AID - 6862895 [pii]
AID - dgac695 [pii]
AID - 10.1210/clinem/dgac695 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2023 Apr 13;108(5):1101-1109. doi: 
      10.1210/clinem/dgac695.