PMID- 36458948
OWN - NLM
STAT- MEDLINE
DCOM- 20230906
LR  - 20230906
IS  - 1943-7730 (Electronic)
IS  - 0007-5027 (Linking)
VI  - 54
IP  - 5
DP  - 2023 Sep 5
TI  - Transfusion-Related Acute Lung Injury Caused by HLA-II Antibodies: A Case Report.
PG  - e117-e120
LID - 10.1093/labmed/lmac145 [doi]
AB  - OBJECTIVE: The aim of this study was to retrospectively analyze the etiology of a 
      case of suspected transfusion-related acute lung injury (TRALI) occurring after 
      blood transfusion. METHODS: The clinical symptoms, signs, imaging examinations, 
      and laboratory test results of a patient with suspected TRALI after blood 
      transfusion were retrospectively analyzed, and human leukocyte antigen (HLA) 
      genotyping of the patient and HLA antibodies of the plasma donors were performed. 
      RESULTS: The clinical manifestations of the patient were consistent with those of 
      TRALI after blood transfusion. This TRALI was treated by timely ventilator 
      support. The patient results of high-resolution HLA genotyping were HLA-A* 01:01, 
      11:01; HLA-B* 15:02, 37:01; HLA-C* 06:02, 08:01; DRB1* 10:01, 12:02; DRB3* 03:01, 
      03:01; DQA1* 01:05, 06:01; DQB1* 03:01, 05:01; DPA1* 01:03, 02:01; and DPB1* 
      02:01, 09:01. Of the 6 plasma donors tested, 3 were found to have HLA-II 
      antibodies, which were HLA-DPA1*01:03, HLA-DQB1*03:01, and HLA-DQB1*03:01 
      antibodies. CONCLUSION: We described a case of TRALI caused by HLA-DQB1*03:01 
      antibody and DPA1*01:03 antibody.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of American 
      Society for Clinical Pathology. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Hao, Xinxin
AU  - Hao X
AD  - Department of Blood Transfusion, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning, 110004, China.
FAU - Wang, Jue
AU  - Wang J
AD  - Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Peking Union 
      Medical College, Institute of Blood Transfusion Chengdu, Sichuan, China.
FAU - Li, Tiegang
AU  - Li T
AD  - Department of Emergency Medicine, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning, 110004, China.
FAU - Wang, Qiushi
AU  - Wang Q
AD  - Department of Blood Transfusion, Shengjing Hospital of China Medical University, 
      Shenyang, Liaoning, 110004, China.
LA  - eng
GR  - 2021JH2/10300045/Liaoning Science and Technology Program/
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Lab Med
JT  - Laboratory medicine
JID - 0250641
RN  - 0 (Antibodies)
SB  - IM
MH  - Humans
MH  - *Transfusion-Related Acute Lung Injury/diagnosis
MH  - Retrospective Studies
MH  - Antibodies
MH  - Blood Donors
OTO - NOTNLM
OT  - HLA-DP19
OT  - HLA-DQ7
OT  - TRALI
OT  - adverse transfusion reaction
OT  - human leukocyte antigen
OT  - transfusion-related acute lung injury
EDAT- 2022/12/03 06:00
MHDA- 2023/09/06 06:42
CRDT- 2022/12/02 09:33
PHST- 2023/09/06 06:42 [medline]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/02 09:33 [entrez]
AID - 6865141 [pii]
AID - 10.1093/labmed/lmac145 [doi]
PST - ppublish
SO  - Lab Med. 2023 Sep 5;54(5):e117-e120. doi: 10.1093/labmed/lmac145.