PMID- 36459413
OWN - NLM
STAT- MEDLINE
DCOM- 20230124
LR  - 20230124
IS  - 1473-2165 (Electronic)
IS  - 1473-2130 (Linking)
VI  - 22
IP  - 1
DP  - 2023 Jan
TI  - Clinical outcomes after lip injection procedures-Comparison of two hyaluronic 
      acid gel fillers with different product properties.
PG  - 119-127
LID - 10.1111/jocd.15548 [doi]
AB  - BACKGROUND: Transient swelling is common after lip injections with hyaluronic 
      acid (HA) based fillers. Swelling and other injection-site reactions may relate 
      to the injection procedure itself, or to gel properties, which differ between 
      fillers due to differences in manufacturing methods. OBJECTIVES: To evaluate 
      safety and effectiveness of lip injections with two HA fillers manufactured using 
      different gel technologies. METHODS: In a study sample of 40 subjects, treatment 
      with two soft tissue filler product (HA(RK) or HA(JUS) ) was randomly assigned. 
      Subjects were injected with 0.5 cc per upper and lower lip using a standardized 
      injection procedure. Early-onset adverse events (AEs) were assessed by evaluation 
      up to Day 14. Aesthetic improvement, subject satisfaction, and AEs post-Day 14 
      were assessed up to 24 weeks. RESULTS: In subjects treated with HA(RK) , the 
      intensity of early onset swelling, erythema, and pain/tenderness was lower than 
      in subjects treated with HA(JUS) . Aesthetic improvement was achieved in both 
      groups, and most subjects were satisfied with the appearance of their lips. 
      Treatment-related AEs post-Day 14 mostly related to the implant site; most were 
      mild-to-moderate, and none were serious. CONCLUSIONS: The intensity of 
      early-onset swelling, and other injection-site reactions was lower in subjects 
      treated with HA(RK) than in subjects treated with HA(JUS) . Since both the 
      injection volume and injection procedure were standardized, the difference in 
      local tolerability between the two HA fillers may relate to differences in gel 
      properties. Aesthetic improvement, subject satisfaction, and AE profiles post-Day 
      14, however, were similar between filler groups.
CI  - (c) 2022 The Authors. Journal of Cosmetic Dermatology published by Wiley 
      Periodicals LLC.
FAU - Hilton, Said
AU  - Hilton S
AD  - Private practice, Duesseldorf, Germany.
FAU - Frank, Konstantin
AU  - Frank K
AUID- ORCID: 0000-0001-6994-8877
AD  - Department for Hand, Plastic and Aesthetic Surgery, Ludwig - Maximilian 
      University Munich, Munich, Germany.
FAU - Alfertshofer, Michael
AU  - Alfertshofer M
AUID- ORCID: 0000-0002-4892-2376
AD  - Department for Hand, Plastic and Aesthetic Surgery, Ludwig - Maximilian 
      University Munich, Munich, Germany.
FAU - Cotofana, Sebastian
AU  - Cotofana S
AUID- ORCID: 0000-0001-7210-6566
AD  - Department of Clinical Anatomy, Mayo Clinic College of Medicine and Science, 
      Rochester, Minnesota, USA.
LA  - eng
GR  - Galderma/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20221202
PL  - England
TA  - J Cosmet Dermatol
JT  - Journal of cosmetic dermatology
JID - 101130964
RN  - 0 (Dermal Fillers)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Humans
MH  - *Cosmetic Techniques/adverse effects
MH  - *Dermal Fillers/adverse effects
MH  - Edema/chemically induced
MH  - *Hyaluronic Acid/adverse effects
MH  - Injection Site Reaction/etiology
MH  - Injections/adverse effects
MH  - Lip
MH  - Pain/etiology
MH  - Skin Aging
MH  - Treatment Outcome
OTO - NOTNLM
OT  - clinical outcomes
OT  - hyaluronic acid gel fillers
OT  - lip injection
OT  - rheology
EDAT- 2022/12/03 06:00
MHDA- 2023/01/24 06:00
CRDT- 2022/12/02 11:54
PHST- 2022/11/02 00:00 [revised]
PHST- 2022/10/11 00:00 [received]
PHST- 2022/11/21 00:00 [accepted]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2023/01/24 06:00 [medline]
PHST- 2022/12/02 11:54 [entrez]
AID - 10.1111/jocd.15548 [doi]
PST - ppublish
SO  - J Cosmet Dermatol. 2023 Jan;22(1):119-127. doi: 10.1111/jocd.15548. Epub 2022 Dec 
      2.