PMID- 36459908
OWN - NLM
STAT- MEDLINE
DCOM- 20221227
LR  - 20221230
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 16
IP  - 12
DP  - 2022 Dec
TI  - The effect of topical olive oil dressing on the healing of grade 1 and 2 diabetic 
      foot ulcers: An assessor-blind randomized controlled trial in type 2 diabetes 
      patients.
PG  - 102678
LID - S1871-4021(22)00295-8 [pii]
LID - 10.1016/j.dsx.2022.102678 [doi]
AB  - BACKGROUND AND AIMS: We aimed to compare the effect of topical olive oil dressing 
      plus standard care with standard care alone on the treatment of grade 1 and 2 
      diabetic foot ulcers (DFUs) in type 2 diabetes mellitus (T2DM) patients. METHODS: 
      This assessor-blind randomized controlled trial included 60 T2DM patients with 
      DFU referred to the Diabetes Clinic of Shahid Mohammadi Hospital, Bandar Abbas, 
      Iran, from February 21 to August 22, 2017. Patients were randomly assigned to 
      intervention (n = 30) and control (n = 30) groups. The intervention group 
      received standard care, including wound irrigation with normal saline and oral 
      antibiotics plus daily topical olive oil dressing for four weeks, and the control 
      group only received standard care. The wound healing assessment scale (wound 
      degree, color, drainage, and surrounding tissue healing) was recorded weekly and 
      the total wound status was determined at the end of the study. RESULTS: Treatment 
      with olive oil led to significantly higher scores of ulcer degree, color, 
      drainage, and surrounding tissue healing at weeks one, two, three and four in the 
      olive oil group than in the control group (P < 0.001). Also, the total wound 
      status score was higher in the olive oil group compared to the control group 
      (P < 0.001). The proportions of completely healed, partially healed, and unhealed 
      wounds were 76.6%, 23.3% and 0% in the intervention group, and 0%, 93.3% and 6.7% 
      in the control group, respectively. CONCLUSIONS: Topical olive oil dressing 
      promoted the healing of DFU and it can be recommended as a safe and effective 
      treatment in this regard. TRIAL REGISTRATION: Iranian Registry of Clinical Trials 
      (IRCT), IRCT20150607022585N4. Registered 05/12/2018. Retrospectively registered, 
      https://www.irct.ir/trial/19460.
CI  - Copyright (c) 2022. Published by Elsevier Ltd.
FAU - Abdoli, Aminreza
AU  - Abdoli A
AD  - Student Research Committee, Faculty of Medicine, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Shahbazi, Roghayeh
AU  - Shahbazi R
AD  - Department of Cellular and Molecular Medicine, Faculty of Medicine, University of 
      Ottawa, Ottawa, Canada.
FAU - Zoghi, Ghazal
AU  - Zoghi G
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Davoodian, Parivash
AU  - Davoodian P
AD  - Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, 
      Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
FAU - Kheirandish, Somayeh
AU  - Kheirandish S
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Azad, Mohsen
AU  - Azad M
AD  - Student Research Committee, Faculty of Medicine, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Kheirandish, Masoumeh
AU  - Kheirandish M
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran. Electronic address: kheirandishm@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20221123
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Olive Oil)
SB  - IM
MH  - Humans
MH  - *Diabetic Foot/drug therapy
MH  - *Diabetes Mellitus, Type 2/complications/therapy
MH  - Olive Oil/therapeutic use/pharmacology
MH  - *Olea
MH  - Iran/epidemiology
MH  - Bandages
MH  - Wound Healing
OTO - NOTNLM
OT  - Diabetes
OT  - Diabetic foot
OT  - Healing
OT  - Olive oil
COIS- Declaration of competing interest The authors declare that they have no conflict 
      of interest.
EDAT- 2022/12/03 06:00
MHDA- 2022/12/28 06:00
CRDT- 2022/12/02 18:25
PHST- 2022/02/07 00:00 [received]
PHST- 2022/11/05 00:00 [revised]
PHST- 2022/11/17 00:00 [accepted]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/28 06:00 [medline]
PHST- 2022/12/02 18:25 [entrez]
AID - S1871-4021(22)00295-8 [pii]
AID - 10.1016/j.dsx.2022.102678 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2022 Dec;16(12):102678. doi: 10.1016/j.dsx.2022.102678. 
      Epub 2022 Nov 23.