PMID- 36460985
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20221213
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Dec 2
TI  - Epicardial adipose tissue thickness is related to early subclinical myocardial 
      dysfunction, particularly in patients with type 2 diabetes mellitus: a case 
      control study.
PG  - 514
LID - 10.1186/s12872-022-02944-8 [doi]
LID - 514
AB  - BACKGROUND: Cardiac myofibrillary dysfunction, which can be measure by 
      echocardiographical strain value, represents an early subclinical manifestation 
      of heart failure. Epicardial Adipose tissue (EAT) is related to low degree 
      inflammation and oxidative damage in the adjacent tissue. AIM: To explore whether 
      EAT affects early myocardial dysfunction, as assessed strain values. METHODS: 
      Case-Control design. Patients lacking clinical significant heart failure, thyroid 
      or renal disease or malignant abnormalities were included. Clinical-demographic 
      and biochemical data were collected. EAT and myofibril deformation were measured 
      by echocardiography. RESULTS: A total of 71 patients were analyzed, and further 
      subdivided according to type 2 Diabetes Mellitus (t2DM). Higher strain value 
      (higher than -22.4%cut-off value) was associated with male sex and higher 
      anthropometric and metabolic risk measures; particularly those with t2DM. Higher 
      EAT was also associated higher strain value (AUC = 0.92 +/- 0.06, p = 0.004), and 
      further correlation was evidenced (rho = 0.488, p < 0.001), with significant 
      influence of t2DM. CONCLUSION: EAT was related to strain value, suggesting the 
      influence of cardiac adipose tissue on the deformability of cardiac myofibril, 
      with a more significant effect in the population with t2DM.
CI  - (c) 2022. The Author(s).
FAU - Prestegui-Munoz, David Eduardo
AU  - Prestegui-Munoz DE
AD  - Hospital General de Ticoman, Secretaria de Salud Ciudad de Mexico, Mexico City, 
      Mexico.
FAU - Benitez-Maldonado, Daniel Rabindranath
AU  - Benitez-Maldonado DR
AD  - Hospital General de Ticoman, Secretaria de Salud Ciudad de Mexico, Mexico City, 
      Mexico.
FAU - Rodriguez-Alvarez, Karen
AU  - Rodriguez-Alvarez K
AD  - Hospital General de Ticoman, Secretaria de Salud Ciudad de Mexico, Mexico City, 
      Mexico.
FAU - de Jesus Prestegui-Munoz, Jose Angel
AU  - de Jesus Prestegui-Munoz JA
AD  - Escuela Nacional de Medicina y Homeopatia, Instituto Politecnico Nacional, Mexico 
      City, Mexico.
FAU - Melchor-Lopez, Alberto
AU  - Melchor-Lopez A
AD  - Hospital General Xoco, Secretaria de Salud Ciudad de Mexico, Mexico City, Mexico.
FAU - Suarez-Cuenca, Juan Antonio
AU  - Suarez-Cuenca JA
AD  - Hospital General Xoco, Secretaria de Salud Ciudad de Mexico, Mexico City, Mexico. 
      suarej05@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20221202
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Humans
MH  - Male
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Case-Control Studies
MH  - Adipose Tissue/diagnostic imaging
MH  - Heart
MH  - *Heart Failure
PMC - PMC9717527
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Epicardial adipose thickness
OT  - Strain
COIS- The authors declare no conflict of interest.
EDAT- 2022/12/03 06:00
MHDA- 2022/12/07 06:00
PMCR- 2022/12/02
CRDT- 2022/12/02 23:45
PHST- 2022/01/15 00:00 [received]
PHST- 2022/11/09 00:00 [accepted]
PHST- 2022/12/02 23:45 [entrez]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/12/02 00:00 [pmc-release]
AID - 10.1186/s12872-022-02944-8 [pii]
AID - 2944 [pii]
AID - 10.1186/s12872-022-02944-8 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2022 Dec 2;22(1):514. doi: 10.1186/s12872-022-02944-8.