PMID- 36461063
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20221206
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 23
IP  - 1
DP  - 2022 Dec 3
TI  - Enthesitis-related arthritis: the clinical characteristics and factors related to 
      MRI remission of sacroiliitis.
PG  - 1054
LID - 10.1186/s12891-022-06028-8 [doi]
LID - 1054
AB  - BACKGROUND: To describe the clinical characteristics and explore the factors 
      related to the MRI remission of sacroiliitis in patients with enthesitis-related 
      arthritis (ERA). METHODS: Patients with ERA from 2018-2022 in our medical center 
      were retrospectively reviewed, which identified according to Pediatric 
      Rheumatology International Trials Organization (PRINTO) criteria. Demographics, 
      clinical characteristics, examinations, and treatments were described. Univariate 
      and multivariate logistic regression models were used to analyze the factors 
      related to MRI remission of sacroiliitis in ERA. RESULTS: This retrospective 
      study included 160 ERA patients (51.9% male) with a mean onset age of 
      9.2 +/- 3.0 years. There were 144 cases (81.9%) with peripheral arthritis, and the 
      hip, knee, and ankle joints were the most commonly involved joints. Enthesitis 
      occurred in 48 cases (30.0%), and sacroiliitis occurred in 142 cases (88.5%) at 
      diagnosis. Human leukocyte antigen (HLA)-B27 was positive in 33 cases (17.1%), 
      and acute uveitis occurred in 3 cases (1.9%). The majority of patients (93.7%) 
      were treated with disease-modifying anti-rheumatic drugs (DMARDs), and 60% with 
      biologics. Among 62 patients with MRI-defined sacroiliitis, 27 (43.5%) 
      cases showed improvement in the sacroiliac joint lesion after treatment. 
      Multivariate logistic regression analysis showed that duration from onset to 
      diagnosis of less than 3 months (OR = 3.609, 95% CI: 1.068-12.192) and active 
      joints of more than 4 (OR = 4.916, 95% CI: 1.006-24.037) were independent 
      factors. CONCLUSION: We highlighted differences in ERA clinical characteristics. 
      Patients with a shorter diagnosis time and more joint involvement improved more 
      significantly in sacroiliac joint lesions after treatment.
CI  - (c) 2022. The Author(s).
FAU - Li, Jiaoyu
AU  - Li J
AD  - Department of Pediatric Nephrology and Rheumatology, Xinhua Hospital Affiliated 
      to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
FAU - Zhu, Yaju
AU  - Zhu Y
AD  - Department of Pediatric Nephrology and Rheumatology, Xinhua Hospital Affiliated 
      to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
FAU - Guo, Guimei
AU  - Guo G
AD  - Department of Pediatric Nephrology and Rheumatology, Xinhua Hospital Affiliated 
      to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. 
      chenguoguimei@126.com.
LA  - eng
PT  - Journal Article
DEP - 20221203
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
RN  - 0 (Antirheumatic Agents)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Child
MH  - Humans
MH  - Male
MH  - Female
MH  - *Sacroiliitis/diagnostic imaging/drug therapy
MH  - Retrospective Studies
MH  - *Arthritis, Juvenile
MH  - Sacroiliac Joint/diagnostic imaging
MH  - Magnetic Resonance Imaging
MH  - *Antirheumatic Agents/therapeutic use
MH  - HLA-B27 Antigen
PMC - PMC9719177
OTO - NOTNLM
OT  - Clinical factor
OT  - Enthesitis
OT  - Juvenile idiopathic arthritis
OT  - Remission
OT  - Sacroiliitis
COIS- The authors have no relevant financial or non-financial interests to disclose.
EDAT- 2022/12/03 06:00
MHDA- 2022/12/07 06:00
PMCR- 2022/12/03
CRDT- 2022/12/02 23:51
PHST- 2022/08/24 00:00 [received]
PHST- 2022/11/25 00:00 [accepted]
PHST- 2022/12/02 23:51 [entrez]
PHST- 2022/12/03 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/12/03 00:00 [pmc-release]
AID - 10.1186/s12891-022-06028-8 [pii]
AID - 6028 [pii]
AID - 10.1186/s12891-022-06028-8 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2022 Dec 3;23(1):1054. doi: 10.1186/s12891-022-06028-8.