PMID- 36461234 OWN - NLM STAT- MEDLINE DCOM- 20221206 LR - 20221206 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 162 IP - Pt A DP - 2022 Dec TI - Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice. PG - 112008 LID - S0963-9969(22)01066-3 [pii] LID - 10.1016/j.foodres.2022.112008 [doi] AB - This study examined the chemical compounds and bioactivity of the aqueous extract of Clitoria ternatea blue petals and investigated its beneficial effects in vivo on a mouse model of obesity and metabolic syndrome. The extract mainly contained flavonoids, and nine compounds were tentatively identified. Male C57BL/6J mice were either fed a standard diet (SD) or a high-fat, high-fructose diet (HFFD) for 16 weeks, and HFFD-fed animals were treated with 0.25%, 0.5%, and 2% (w/w) of the aqueous extract in drinking water. The aqueous extract ameliorated oxidative stress and inflammation mediators. Furthermore, the aqueous extract reduced plasma leptin, free fatty acid, low-density lipoprotein cholesterol levels and hepatic malondialdehyde content. The aqueous extract significantly reduced total cholesterol and ameliorated insulin resistance. The results demonstrated that the aqueous extract of C. ternatea blue petals contains bioactive anthocyanins that exert substantial hypolipidemic and anti-inflammatory effects by promoting reverse cholesterol transport in HFFD-fed mice. CI - Copyright (c) 2022 Elsevier Ltd. All rights reserved. FAU - Wang, Yijun AU - Wang Y AD - State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. FAU - Liu, Tiantian AU - Liu T AD - State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. FAU - Xie, Yanmei AU - Xie Y AD - State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. FAU - Li, Na AU - Li N AD - State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. FAU - Liu, Yan AU - Liu Y AD - State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. FAU - Wen, Jiaqiang AU - Wen J AD - State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. FAU - Zhang, Man AU - Zhang M AD - State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. FAU - Feng, Wanjie AU - Feng W AD - State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. FAU - Huang, Jinbao AU - Huang J AD - State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, PR China. FAU - Guo, Yuanxin AU - Guo Y AD - School of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212003, PR China. FAU - Kabbas Junior, Tufy AU - Kabbas Junior T AD - Graduate Program in Chemistry, State University of Ponta Grossa (UEPG), Av. Carlos Cavalcanti, 4748, Ponta Grossa 84030-900, Parana, Brazil. FAU - Wang, Dongxu AU - Wang D AD - School of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu 212003, PR China. Electronic address: wdx@just.edu.cn. FAU - Granato, Daniel AU - Granato D AD - Bioactivity & Applications Lab, Department of Biological Sciences, Faculty of Science and Engineering, University of Limerick, V94 T9PX Limerick, Ireland. Electronic address: daniel.granato@ul.ie. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20221001 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 RN - 30237-26-4 (Fructose) RN - 0 (Anthocyanins) RN - 97C5T2UQ7J (Cholesterol) SB - IM MH - Male MH - Mice MH - Animals MH - *Fructose/adverse effects MH - *Clitoria MH - Anthocyanins MH - Mice, Inbred C57BL MH - Obesity/drug therapy/prevention & control MH - Inflammation/prevention & control MH - Oxidative Stress MH - Cholesterol OTO - NOTNLM OT - Anti-obesity OT - Flavonoids OT - Functional foods OT - In vivo study OT - Low-grade inflammation OT - Reactive oxygen species OT - Reverse cholesterol transport COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/12/04 06:00 MHDA- 2022/12/07 06:00 CRDT- 2022/12/03 01:02 PHST- 2022/07/19 00:00 [received] PHST- 2022/09/26 00:00 [revised] PHST- 2022/09/27 00:00 [accepted] PHST- 2022/12/03 01:02 [entrez] PHST- 2022/12/04 06:00 [pubmed] PHST- 2022/12/07 06:00 [medline] AID - S0963-9969(22)01066-3 [pii] AID - 10.1016/j.foodres.2022.112008 [doi] PST - ppublish SO - Food Res Int. 2022 Dec;162(Pt A):112008. doi: 10.1016/j.foodres.2022.112008. Epub 2022 Oct 1.