PMID- 36461380
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20221208
IS  - 1873-7145 (Electronic)
IS  - 0963-9969 (Linking)
VI  - 162
IP  - Pt B
DP  - 2022 Dec
TI  - Effects of distinct n-6 to n-3 polyunsaturated fatty acid ratios on insulin 
      resistant and AD-like phenotypes in high-fat diets-fed APP/PS1 mice.
PG  - 112207
LID - S0963-9969(22)01265-0 [pii]
LID - 10.1016/j.foodres.2022.112207 [doi]
AB  - Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are prevalent 
      diseases with similar pathophysiological characteristics and genetic 
      predispositions. Polyunsaturated fatty acids (PUFAs) are essential in maintaining 
      normal brain function. However, little is known about the effect of dietary 
      n-6/n-3 PUFA ratio on AD-like pathology, particularly in high-fat diet (HFD)-fed 
      AD model mice. In the present study, the APP/PS1 mice were fed with 60 % HFD for 
      3.5 months to induce insulin resistance. After that, 45 % HFD with various 
      n-6/n-3 PUFA ratios (n-6/n-3 = 1:1, 5:1 or 16:1) was applied for an additional 
      3.5 months of treatment. The behavior of mice was observed using the water maze 
      after dietary intervention. The animals were euthanized after behavioral testing, 
      and serum and tissue samples were collected for biochemical, histological, and 
      pathological tests and evaluation. HFD caused insulin resistance, increased serum 
      IL-6 and TNF-alpha levels, cortical soluble Abeta(1-40), Abeta(1-42) content, and cortical 
      n-6/n-3 PUFA ratio in APP/PS1 mice. Increased APP and BACE1 protein expression 
      and p-IR/IR ratio but decreased pro-inflammatory cytokines mRNA expression was 
      detected in the cortex of 60 % HFD-fed APP/PS1 mice. N-3 PUFAs-rich diet 
      (n-6/n-3 = 1:1) alleviated insulin resistance and hyperlipidemia caused by 60 % 
      HFD. Cortical soluble Abeta(1-40) and Abeta(1-42) contents, as well as the expression 
      of cortical APP, GLUT1, GLUT3, insulin metabolism-related molecules, and NF-kappaB 
      pathway downstream pro-inflammatory cytokines, were found to be n-6/n-3 PUFAs 
      ratio-dependent, indicating that dietary n-6/n-3 PUFA ratio plays a critical role 
      in modifying the responses of serum inflammatory cytokines, AD pathology, 
      cortical n-6/n-3 PUFAs ratio, insulin signaling, and neuroinflammation to HFD 
      treatment.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Ma, Xiaojun
AU  - Ma X
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Capital 
      Medical University, Beijing, China.
FAU - Guo, Yujie
AU  - Guo Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Capital 
      Medical University, Beijing, China.
FAU - Xu, Jingjing
AU  - Xu J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Capital 
      Medical University, Beijing, China.
FAU - Wang, Xixiang
AU  - Wang X
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Capital 
      Medical University, Beijing, China.
FAU - Dong, Shengqi
AU  - Dong S
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Capital 
      Medical University, Beijing, China.
FAU - Gao, Yanyan
AU  - Gao Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Capital 
      Medical University, Beijing, China.
FAU - Van Halm-Lutterodt, Nicholas
AU  - Van Halm-Lutterodt N
AD  - School of Professional Studies, Brown University, Providence, RI, United States.
FAU - Yuan, Linhong
AU  - Yuan L
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Capital 
      Medical University, Beijing, China; Beijing Key Laboratory of Environmental 
      Toxicology, Capital Medical University, Beijing, China. Electronic address: 
      ylhmedu@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221119
PL  - Canada
TA  - Food Res Int
JT  - Food research international (Ottawa, Ont.)
JID - 9210143
RN  - 0 (Insulin)
RN  - 0 (Fatty Acids, Omega-3)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - EC 3.4.23.- (Aspartic Acid Endopeptidases)
RN  - 0 (Cytokines)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Insulin
MH  - Diet, High-Fat/adverse effects
MH  - *Fatty Acids, Omega-3
MH  - *Alzheimer Disease
MH  - *Insulin Resistance
MH  - *Diabetes Mellitus, Type 2
MH  - Amyloid Precursor Protein Secretases
MH  - Aspartic Acid Endopeptidases
MH  - Phenotype
MH  - Cytokines
OTO - NOTNLM
OT  - AD-like pathology
OT  - APP/PS1 mice
OT  - High-fat diet
OT  - Insulin resistance
OT  - N-6/n-3 PUFA ratio
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/04 06:00
MHDA- 2022/12/07 06:00
CRDT- 2022/12/03 01:02
PHST- 2022/08/30 00:00 [received]
PHST- 2022/11/12 00:00 [revised]
PHST- 2022/11/15 00:00 [accepted]
PHST- 2022/12/03 01:02 [entrez]
PHST- 2022/12/04 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
AID - S0963-9969(22)01265-0 [pii]
AID - 10.1016/j.foodres.2022.112207 [doi]
PST - ppublish
SO  - Food Res Int. 2022 Dec;162(Pt B):112207. doi: 10.1016/j.foodres.2022.112207. Epub 
      2022 Nov 19.