PMID- 36463992
OWN - NLM
STAT- MEDLINE
DCOM- 20230117
LR  - 20230223
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 219
DP  - 2023 Feb 15
TI  - Association between prenatal metals exposure and blood pressure in 5-6 years 
      children: A birth cohort study.
PG  - 114974
LID - S0013-9351(22)02301-5 [pii]
LID - 10.1016/j.envres.2022.114974 [doi]
AB  - BACKGROUND: The trajectory of blood pressure (BP) from childhood to early middle 
      age suggested that individuals with elevated BP in early childhood were more 
      likely to be affected by cardiovascular disease in adulthood. Exposure to metals 
      may affect BP in children, and pregnancy is a sensitive time for metal exposure. 
      This study assessed the relationship between different stages of prenatal 
      exposure to metals or metal mixtures and BP in children aged 5-6 years. METHODS: 
      The study included 2535, 2680, 2534 mother-child pairs in three trimesters, from 
      the Ma'anshan birth cohort study (MABC). We collected maternal blood samples 
      during pregnancy and measured the serum levels of four metals (arsenic, selenium, 
      cadmium, and mercury). BP was measured in children aged 5-6 years. A linear 
      regression model and Bayesian kernel machine regression (BKMR) were used to 
      explore associations between prenatal exposure to metals at different stages and 
      multiple metal exposure with BP in children aged 5-6 years. RESULTS: Associations 
      were observed between the arsenic in the third trimester and children's diastolic 
      blood pressure (DBP) (beta = 0.88, 95% CI: 0.44, 1.33), systolic blood pressure 
      (SBP) (beta = 0.72, 95% CI: 0.19, 1.24) and mean arterial pressure (MAP) (beta = 0.83, 
      95% CI: 0.42, 1.23), as well as between the mercury and children's DBP (beta = 0.65, 
      95% CI: 0.13, 1.16) and MAP (beta = 0.60, 95% CI: 0.14, 1.07). The BKMR analysis 
      showed that multiple metals had a significant positive joint effect on children's 
      DBP, SBP and MAP. A potential interaction between arsenic and mercury was 
      observed (beta = -0.85, 95% CI: -1.62, -0.08). CONCLUSIONS: Exposure to arsenic and 
      mercury during pregnancy was associated with altered BP in children. The third 
      trimester may represent an important window of opportunity to reduce the effects 
      of metal exposure on children's blood pressure and long-term health.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Ma, Yufan
AU  - Ma Y
AD  - Department of Maternal, Child and Adolescent Health, Anhui Medical University, 
      Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, 
      No 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Liang, Chunmei
AU  - Liang C
AD  - Department of Maternal, Child and Adolescent Health, Anhui Medical University, 
      Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, 
      No 81 Meishan Road, Hefei, 230032, Anhui, China; NHC Key Laboratory of Study on 
      Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, Anhui, China.
FAU - Wang, Zihan
AU  - Wang Z
AD  - Department of Maternal, Child and Adolescent Health, Anhui Medical University, 
      Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, 
      No 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Wang, Xing
AU  - Wang X
AD  - Department of Maternal, Child and Adolescent Health, Anhui Medical University, 
      Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, 
      No 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Xie, Liangliang
AU  - Xie L
AD  - Ma'anshan Maternal and Child Health Center, No 446 Jiashan Road, Ma'anshan, Anhui 
      Province, China.
FAU - Tao, Shuman
AU  - Tao S
AD  - MOE Key Laboratory of Population Health Across Life Cycle, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health 
      & Aristogenics, Hefei, Anhui, China.
FAU - Yan, Shuangqin
AU  - Yan S
AD  - Ma'anshan Maternal and Child Health Center, No 446 Jiashan Road, Ma'anshan, Anhui 
      Province, China.
FAU - Wu, Xiaoyan
AU  - Wu X
AD  - Department of Maternal, Child and Adolescent Health, Anhui Medical University, 
      Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, 
      No 81 Meishan Road, Hefei, 230032, Anhui, China; NHC Key Laboratory of Study on 
      Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, Anhui, China.
FAU - Wei, Zhaolian
AU  - Wei Z
AD  - MOE Key Laboratory of Population Health Across Life Cycle, No 81 Meishan Road, 
      Hefei, 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and 
      Reproductive Tract, No 81 Meishan Road, Hefei, 230032, Anhui, China.
FAU - Tong, Juan
AU  - Tong J
AD  - Department of Maternal, Child and Adolescent Health, Anhui Medical University, 
      Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, 
      No 81 Meishan Road, Hefei, 230032, Anhui, China; NHC Key Laboratory of Study on 
      Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, Anhui, China.
FAU - Tao, Xingyong
AU  - Tao X
AD  - Department of Maternal, Child and Adolescent Health, Anhui Medical University, 
      Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, 
      No 81 Meishan Road, Hefei, 230032, Anhui, China; NHC Key Laboratory of Study on 
      Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, Anhui, China. Electronic address: txyayd@126.com.
FAU - Tao, Fangbiao
AU  - Tao F
AD  - Department of Maternal, Child and Adolescent Health, Anhui Medical University, 
      Hefei, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, 
      No 81 Meishan Road, Hefei, 230032, Anhui, China; NHC Key Laboratory of Study on 
      Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei, 230032, 
      Anhui, China; Anhui Provincial Key Laboratory of Population Health & 
      Aristogenics, Hefei, Anhui, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221201
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - N712M78A8G (Arsenic)
RN  - 0 (Metals)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Blood Pressure
MH  - *Arsenic/toxicity
MH  - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology
MH  - Bayes Theorem
MH  - Metals
MH  - *Mercury
OTO - NOTNLM
OT  - BKMR
OT  - Blood pressure
OT  - Child health
OT  - Metal mixtures
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/05 06:00
MHDA- 2023/01/18 06:00
CRDT- 2022/12/04 19:24
PHST- 2022/10/08 00:00 [received]
PHST- 2022/11/20 00:00 [revised]
PHST- 2022/11/28 00:00 [accepted]
PHST- 2022/12/05 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2022/12/04 19:24 [entrez]
AID - S0013-9351(22)02301-5 [pii]
AID - 10.1016/j.envres.2022.114974 [doi]
PST - ppublish
SO  - Environ Res. 2023 Feb 15;219:114974. doi: 10.1016/j.envres.2022.114974. Epub 2022 
      Dec 1.