PMID- 36464196
OWN - NLM
STAT- MEDLINE
DCOM- 20230112
LR  - 20230112
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 227
DP  - 2023 Feb 1
TI  - Preparation of new hydrogels by visible light cross-linking of dextran 
      methacrylate and poly(ethylene glycol)-maleic acid copolymer.
PG  - 1221-1233
LID - S0141-8130(22)02875-6 [pii]
LID - 10.1016/j.ijbiomac.2022.11.309 [doi]
AB  - In this work, a series of new biodegradable and biocompatible hydrogels were 
      synthesized by photopolymerization of dextran-methacrylate (DXM) with 
      poly(ethylene glycol)-maleic acid copolymer (poly(PEG-co-MA, PEGMA)) using 
      (-)-riboflavin as a visible light photoinitiator and L-arginine as a 
      co-photoinitiator. DXM was prepared by acylation of dextran (DX) with 
      methacryloyl chloride (MAC), and PEGMA was synthesized by polycondensation of 
      poly(ethylene glycol) (PEG) and maleic acid (MA). The DXM and PEGMA were 
      characterized by FT-IR and (1)HNMR spectroscopy. Different types of hydrogels 
      from various ratios of DXM and PEGMA were prepared and characterized by SEM. The 
      results showed that the prepared hydrogel by photo-cross-linking of DXM (DPHG0) 
      was transparent and flexible, and its physical shape was excellent, but it was 
      sticky. The stickiness was reduced by increasing the PEGMA contents, and 
      different types of DXM/PEGMA hydrogels (DPHG1-4) with various properties were 
      prepared. For example, DPHG2 (PEGMA content was 0.25 g) was transparent and 
      flexible, its physical shape was excellent, and it was not sticky. The prepared 
      hydrogels showed excellent cytocompatibility, and their tensile and compressive 
      strength were also evaluated. Additionally, the in vitro degradation and swelling 
      ratios of the prepared hydrogels were studied in buffer solution at different 
      pHs.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Kolahdoozan, Majid
AU  - Kolahdoozan M
AD  - Department of Chemistry, Shahreza Branch, Islamic Azad University, P.O. Box 
      311-86145, Shahreza, Isfahan, Iran. Electronic address: kolahdoozan@iaush.ac.ir.
FAU - Rahimi, Tayebeh
AU  - Rahimi T
AD  - Department of Chemistry, Shahreza Branch, Islamic Azad University, P.O. Box 
      311-86145, Shahreza, Isfahan, Iran.
FAU - Taghizadeh, Ameneh
AU  - Taghizadeh A
AD  - Department of Chemistry, Shahreza Branch, Islamic Azad University, P.O. Box 
      311-86145, Shahreza, Isfahan, Iran.
FAU - Aghaei, Hamidreza
AU  - Aghaei H
AD  - Department of Chemistry, Shahreza Branch, Islamic Azad University, P.O. Box 
      311-86145, Shahreza, Isfahan, Iran. Electronic address: haghaei@iaush.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20221202
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 0 (Hydrogels)
RN  - 91XW058U2C (maleic acid)
RN  - 0 (Dextrans)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
RN  - 0 (Methacrylates)
SB  - IM
MH  - *Polyethylene Glycols/chemistry
MH  - *Hydrogels/chemistry
MH  - Dextrans/chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Biocompatible Materials/chemistry
MH  - Polymers/chemistry
MH  - Methacrylates/chemistry
MH  - Light
OTO - NOTNLM
OT  - Biocompatible hydrogels
OT  - Dextran
OT  - Photo-cross-linking
COIS- Conflict of interest The authors declare that they have no known competing 
      financial interests or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2022/12/05 06:00
MHDA- 2023/01/13 06:00
CRDT- 2022/12/04 19:27
PHST- 2022/09/11 00:00 [received]
PHST- 2022/11/22 00:00 [revised]
PHST- 2022/11/29 00:00 [accepted]
PHST- 2022/12/05 06:00 [pubmed]
PHST- 2023/01/13 06:00 [medline]
PHST- 2022/12/04 19:27 [entrez]
AID - S0141-8130(22)02875-6 [pii]
AID - 10.1016/j.ijbiomac.2022.11.309 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2023 Feb 1;227:1221-1233. doi: 
      10.1016/j.ijbiomac.2022.11.309. Epub 2022 Dec 2.