PMID- 36465076
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221206
IS  - 2719-4523 (Electronic)
IS  - 2719-4523 (Linking)
VI  - 1
IP  - 1
DP  - 2020 Dec
TI  - The Dawn of a New Era of Therapies in Systemic Lupus Erythematosus.
PG  - 31-37
LID - 10.2478/rir-2020-0005 [doi]
AB  - Systemic lupus erythematosus (SLE) is a complicated multisystem autoimmune 
      disease that is associated with significant mortality and morbidity in the 
      younger population. The development of novel therapies of SLE lag behinds other 
      autoimmune inflammatory rheumatic diseases because of its clinical and 
      immunological heterogeneities, the complexity of outcome assessments in multiple 
      systems, and difficulty in optimizing the design of clinical trials. Despite the 
      futility of quite a number of clinical trials, we are seeing the dawn of novel 
      therapeutics in SLE, given the promising results of the newer-generation 
      anti-CD20, anti-CD40L biologics, and calcineurin inhibitors (CNIs), as well as 
      anti-cytokine biologics, Jakinibs, and the mammalian target of rapamycin (mTOR) 
      inhibitors. The initial success of the Jakinibs and combination regimens in SLE 
      illustrates the importance of targeting multiple pathogenetic mechanisms. The 
      results of the ongoing phase III clinical trials in SLE are eagerly awaited.
CI  - (c) 2020 Chi Chiu Mok, published by Sciendo.
FAU - Mok, Chi Chiu
AU  - Mok CC
AD  - Department of Medicine, Tuen Mun Hospital, Hong Kong SAR, China.
LA  - eng
PT  - Journal Article
DEP - 20201201
PL  - Germany
TA  - Rheumatol Immunol Res
JT  - Rheumatology and immunology research
JID - 9918419176206676
PMC - PMC9524766
OTO - NOTNLM
OT  - advance
OT  - biologics
OT  - lupus
OT  - novel
OT  - therapeutics
EDAT- 2020/12/01 00:00
MHDA- 2020/12/01 00:01
PMCR- 2020/12/01
CRDT- 2022/12/05 03:34
PHST- 2020/06/14 00:00 [received]
PHST- 2020/07/02 00:00 [accepted]
PHST- 2022/12/05 03:34 [entrez]
PHST- 2020/12/01 00:00 [pubmed]
PHST- 2020/12/01 00:01 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - rir-2020-0005 [pii]
AID - 10.2478/rir-2020-0005 [doi]
PST - epublish
SO  - Rheumatol Immunol Res. 2020 Dec 1;1(1):31-37. doi: 10.2478/rir-2020-0005. 
      eCollection 2020 Dec.