PMID- 36465321
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221206
IS  - 2719-4523 (Electronic)
IS  - 2719-4523 (Linking)
VI  - 3
IP  - 2
DP  - 2022 Jun
TI  - Low-energy Pulsed Electromagnetic Field Therapy Reduces Pain in Fibromyalgia: A 
      Randomized Single-blind Controlled Pilot Study.
PG  - 77-83
LID - 10.2478/rir-2022-0013 [doi]
AB  - OBJECTIVES: Fibromyalgia symptoms have a significant impact on the quality of 
      life and respond poorly to medications. It has been hypothesized that the use of 
      low-energy pulsed electromagnetic field (PEMF) induces neuroprotective effects 
      that may interfere with pain perception. We explored the efficacy of PEMF in 
      patients affected by fibromyalgia. METHODS: Twenty-one females (median age 59 
      years, interquartile range [IQR] 16.5) affected by fibromyalgia were randomized 
      to receive pulsed electromagnetic field-triple energy pain treatment (PEMF-TEPT) 
      or placebo at T0 and at 4 weeks and 8 weeks. Fibromyalgia impact questionnaire 
      (FIQ), widespread pain index (WPI), visual analog score (VAS) pain, symptom 
      severity (SS) scale, and short form 36 (SF-36) health survey questionnaire have 
      been evaluated. RESULTS: Patients in the PEMF-TEPT group had a significantly 
      higher reduction of WPI compared to placebo (mean difference -12.90 +/- standard 
      deviation [SD] 5.32 vs. -1.91 +/- 4.55, difference in difference [DD] of -10.99; P 
      < 0.001), of SS score (-4.10 +/- 4.85 vs. -2.00 +/- 2.32; DD = -2.1; P < 0.05), of 
      VAS pain (-48 +/- 30.75 vs. -16.82 +/- 23.69; DD = -31.18; P < 0.01). They also 
      reported a higher improvement of FIQ and SF-36, albeit not reaching statistical 
      significance. CONCLUSION: In our pilot controlled study, PEMF-TEPT appeared to be 
      safe and improved fibromyalgia symptoms.
CI  - (c) 2022 Massimo Giovale et al., published by Sciendo.
FAU - Giovale, Massimo
AU  - Giovale M
AD  - Division of Rheumatology, ASL3 Genovese, Genoa, Italy.
FAU - Novelli, Lucia
AU  - Novelli L
AD  - Rheumatology and Clinical Immunology; IRCCS Humanitas Research Hospital, Rozzano, 
      Milan, Italy.
FAU - Persico, Luca
AU  - Persico L
AD  - Department of Economics, University of Genova, Genoa, Italy.
FAU - Motta, Francesca
AU  - Motta F
AD  - Rheumatology and Clinical Immunology; IRCCS Humanitas Research Hospital, Rozzano, 
      Milan, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, Milan, Italy.
FAU - Rampoldi, Stefano
AU  - Rampoldi S
AD  - THS Therapeutic Solutions srl, Milan, Italy.
FAU - Galli, Rossana
AU  - Galli R
AD  - Division of Rheumatology, ASL3 Genovese, Genoa, Italy.
FAU - Monteforte, Patrizia
AU  - Monteforte P
AD  - Division of Rheumatology, ASL3 Genovese, Genoa, Italy.
FAU - Doveri, Marica
AU  - Doveri M
AD  - Division of Rheumatology, ASL3 Genovese, Genoa, Italy.
FAU - Bianchi, Gerolamo
AU  - Bianchi G
AD  - Division of Rheumatology, ASL3 Genovese, Genoa, Italy.
FAU - Selmi, Carlo
AU  - Selmi C
AD  - Rheumatology and Clinical Immunology; IRCCS Humanitas Research Hospital, Rozzano, 
      Milan, Italy.
AD  - Department of Biomedical Sciences, Humanitas University, Milan, Italy.
FAU - Bottaro, Luigi Carlo
AU  - Bottaro LC
AD  - General Direction, ASL3 Genovese, Genoa, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220706
PL  - Germany
TA  - Rheumatol Immunol Res
JT  - Rheumatology and immunology research
JID - 9918419176206676
PMC - PMC9524818
OTO - NOTNLM
OT  - diffuse pain syndrome
OT  - fatigue
OT  - quality of life
OT  - widespread pain
COIS- Conflicts of Interest Stefano Rampoldi is employed at THS, which provided the 
      device. The other authors certify that there is no conflict of interest with any 
      financial organization regarding the material discussed in the manuscript.
EDAT- 2022/12/06 06:00
MHDA- 2022/12/06 06:01
PMCR- 2022/07/06
CRDT- 2022/12/05 03:38
PHST- 2022/01/11 00:00 [received]
PHST- 2022/03/05 00:00 [accepted]
PHST- 2022/12/05 03:38 [entrez]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2022/12/06 06:01 [medline]
PHST- 2022/07/06 00:00 [pmc-release]
AID - rir-2022-0013 [pii]
AID - 10.2478/rir-2022-0013 [doi]
PST - epublish
SO  - Rheumatol Immunol Res. 2022 Jul 6;3(2):77-83. doi: 10.2478/rir-2022-0013. 
      eCollection 2022 Jun.