PMID- 36465440
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221206
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Left bundle branch area pacing: A promising modality for cardiac 
      resynchronization therapy.
PG  - 901046
LID - 10.3389/fcvm.2022.901046 [doi]
LID - 901046
AB  - Cardiac resynchronization therapy (CRT) is recognized as the first-line 
      management for patients with heart failure (HF) and conduction disorders. As a 
      conventional mode for delivering CRT, biventricular pacing (BVP) improves cardiac 
      function and reduces HF hospitalizations and mortality, but there are still 
      limitations given the high incidence of a lack of response rates. Alternative 
      pacing methods are needed either for primary or rescue therapy. In recent years, 
      conduction system pacing (CSP) has emerged as a more physiological pacing 
      modality for simultaneous stimulation of the ventricles, including His bundle 
      pacing (HBP) and left bundle branch pacing (LBBP). CSP activates the His-Purkinje 
      system, allowing normal ventricular stimulation. However, HBP is technically 
      challenging with a relatively low success rate, high pacing threshold, and 
      failure to correct distal conduction abnormalities. Therefore, LBBP stands out as 
      a novel ideal physiological pacing modality for CRT. Several non-randomized 
      studies compared the feasibility and safety of LBBP with BVP and concluded that 
      LBBP is superior to BVP for delivering CRT with a narrower QRS and greater 
      improvements in left ventricular ejection fraction (LVEF) and New York Heart 
      Association (NYHA) functional class. Concurrently, some studies showed lower and 
      stable pacing thresholds and greater improvement of B-type natriuretic peptide 
      (BNP) levels, as well as better mechanical synchronization and efficiency. LBBP 
      ensures better ventricular electromechanical resynchronization than BVP. In this 
      review, we discuss current knowledge of LBBP, compare LBBP with BVP, and explore 
      the potential of LBBP to serve as an alternative primary therapy to realize 
      cardiac resynchronization.
CI  - Copyright (c) 2022 Fu, Liu, Jin, Li, Zhang, Qin and Zheng.
FAU - Fu, Yuping
AU  - Fu Y
AD  - Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
FAU - Liu, Peng
AU  - Liu P
AD  - Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
FAU - Jin, Lingyan
AU  - Jin L
AD  - Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
FAU - Li, Yingqi
AU  - Li Y
AD  - Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
FAU - Zhang, Yudi
AU  - Zhang Y
AD  - Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
FAU - Qin, Xinghua
AU  - Qin X
AD  - School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 
      China.
FAU - Zheng, Qiangsun
AU  - Zheng Q
AD  - Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20221118
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9715961
OTO - NOTNLM
OT  - biventricular pacing
OT  - cardiac resynchronization therapy
OT  - conduction system pacing
OT  - heart failure
OT  - left bundle branch pacing
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/06 06:00
MHDA- 2022/12/06 06:01
PMCR- 2022/01/01
CRDT- 2022/12/05 03:42
PHST- 2022/03/21 00:00 [received]
PHST- 2022/10/31 00:00 [accepted]
PHST- 2022/12/05 03:42 [entrez]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2022/12/06 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.901046 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Nov 18;9:901046. doi: 10.3389/fcvm.2022.901046. 
      eCollection 2022.