PMID- 36466492
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20230130
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 10
DP  - 2022
TI  - Association of intestinal microbiota markers and dietary pattern in Chinese 
      patients with type 2 diabetes: The Henan rural cohort study.
PG  - 1046333
LID - 10.3389/fpubh.2022.1046333 [doi]
LID - 1046333
AB  - Studies on intestinal microbiota in Chinese type 2 diabetes mellitus (T2DM) 
      patients are scarce and correlation studies with dietary intake are lacking. The 
      case-control study included 150 participants (74 T2DM patients and 76 controls) 
      and microbiome analysis was performed using 16S rDNA sequencing. Principal 
      component analysis was used to determine dietary patterns and correlation 
      analysis was used to evaluate the associations between microbiota diversity, T2DM 
      indicators and dietary variables. Compared to controls, the T2DM group had 
      different gut flora characteristics, including lower alpha diversity, higher 
      Firmicutes/Bacteroidetes ratios, statistically significant beta diversity and 
      other specific bacterial species differences. Gut microbiota was associated with 
      several diabetes-related metabolic markers including HOMA2-beta, fasting plasma 
      glucose, HbA1c and fasting insulin. Significant associations were also observed 
      between dietary intake pattern and gut flora. The animal foods pattern scores 
      were positively correlated with the relative abundance of the phylum 
      Fusobacteria, and the vegetarian diet pattern scores were positively correlated 
      with the relative abundance of the phylum Actinobacteria. Phylum Actinobacteria 
      mediated the association of vegetarian diet pattern with fasting insulin and 
      HOMA2-beta (all P < 0.05). Composition of intestinal microbiota in Chinese T2DM 
      patients differs from that of control population, and the intestinal flora is 
      affected by dietary intake while being associated with several diabetes-related 
      metabolic markers. The gut microbiota may play an important role in linking 
      dietary intake and the etiology of T2DM.
CI  - Copyright (c) 2022 Wang, Lyu, Yang, Cui, Niu, Gu, Li, Li, Xing and Li.
FAU - Wang, Guanjun
AU  - Wang G
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Weifang 
      Medical University, Weifang, China.
FAU - Lyu, Quanjun
AU  - Lyu Q
AD  - Department of Nutrition, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, Henan, China.
FAU - Yang, Tianyu
AU  - Yang T
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, China.
FAU - Cui, Songyang
AU  - Cui S
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, China.
FAU - Niu, Kailin
AU  - Niu K
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, China.
FAU - Gu, Ruohua
AU  - Gu R
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, China.
FAU - Li, Jia
AU  - Li J
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, China.
FAU - Xing, Wenguo
AU  - Xing W
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, China.
FAU - Li, Linlin
AU  - Li L
AD  - Department of Epidemiology and Health Statistics, College of Public Health, 
      Zhengzhou University, Zhengzhou, Henan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221116
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
RN  - 0 (Biomarkers)
RN  - 0 (Insulins)
SB  - IM
MH  - Animals
MH  - *Gastrointestinal Microbiome
MH  - *Diabetes Mellitus, Type 2
MH  - Cohort Studies
MH  - Case-Control Studies
MH  - Biomarkers
MH  - *Insulins
MH  - China
PMC - PMC9709334
OTO - NOTNLM
OT  - 16S rDNA
OT  - T2DM
OT  - diet
OT  - dietary pattern
OT  - gut microbiota
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/06 06:00
MHDA- 2022/12/07 06:00
PMCR- 2022/11/16
CRDT- 2022/12/05 04:04
PHST- 2022/09/16 00:00 [received]
PHST- 2022/10/31 00:00 [accepted]
PHST- 2022/12/05 04:04 [entrez]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/11/16 00:00 [pmc-release]
AID - 10.3389/fpubh.2022.1046333 [doi]
PST - epublish
SO  - Front Public Health. 2022 Nov 16;10:1046333. doi: 10.3389/fpubh.2022.1046333. 
      eCollection 2022.