PMID- 36466832
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20221206
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Systemic immune-inflammation index is associated with hepatic steatosis: Evidence 
      from NHANES 2015-2018.
PG  - 1058779
LID - 10.3389/fimmu.2022.1058779 [doi]
LID - 1058779
AB  - BACKGROUND: As a novel inflammatory marker, Systemic Immune-Inflammation Index 
      (SII) has not been studied with hepatic steatosis. The aim of this study was to 
      investigate the possible relationship between SII and hepatic steatosis. METHODS: 
      In the cross-sectional investigation, adults having complete information on SII, 
      hepatic steatosis, and bariatric surgery from the 2015-2018 National Health and 
      Nutrition Examination Survey (NHANES) were included. Hepatic steatosis was 
      evaluated with heaptic steatosis index (HSI). The platelet count x neutrophil 
      count/lymphocyte count was used to compute SII. We investigated the independent 
      interaction between SII and hepatic steatosis using weighted multivariable 
      regression analysis and subgroup analysis. To explore the potential relationship 
      between SII, bariatric surgery and hepatic steatosis by controlling potential 
      confounders by propensity score matching. RESULTS: The study involved 10505 
      participants in total, 5937 (56.5%) of whom had hepatic steatosis according to 
      the diagnosis. After adjusted for covariates, multivariable logistic regression 
      revealed that high SII level was an independent risk factor for hepatic steatosis 
      (OR = 1.30, 95% CI: 1.10-1.52, P 0.01). Unexpectedly, bariatric surgery reduced 
      SII even after PSM corrected for differences of BMI and HSI. CONCLUSIONS: In US 
      adults, SII was positively correlated with an increase in hepatic steatosis. The 
      SII may be a simple and affordable way to identify hepatic steatosis. Bariatric 
      surgery may reduce SII without resorting to weight loss. This needs to be 
      verified in additional prospective research.
CI  - Copyright (c) 2022 Song, Guo, Li, Guo, Li and Li.
FAU - Song, Yancheng
AU  - Song Y
AD  - Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao 
      University, Qingdao, Shandong, China.
FAU - Guo, Wencong
AU  - Guo W
AD  - Laboratory of Nephrology & Department of Nephrology, The Affiliated Qingdao 
      Municipal Hospital of Qingdao University, Qingdao, Shandong, China.
FAU - Li, Zhaopeng
AU  - Li Z
AD  - Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao 
      University, Qingdao, Shandong, China.
FAU - Guo, Dong
AU  - Guo D
AD  - Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao 
      University, Qingdao, Shandong, China.
FAU - Li, Zhao
AU  - Li Z
AD  - Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao 
      University, Qingdao, Shandong, China.
FAU - Li, Yu
AU  - Li Y
AD  - Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao 
      University, Qingdao, Shandong, China.
LA  - eng
PT  - Journal Article
DEP - 20221118
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Adult
MH  - Humans
MH  - Nutrition Surveys
MH  - Cross-Sectional Studies
MH  - Prospective Studies
MH  - *Fatty Liver
MH  - Inflammation
PMC - PMC9718528
OTO - NOTNLM
OT  - NHANES
OT  - bariatric surgery
OT  - hepatic steatosis
OT  - non-alcoholic fatty liver disease
OT  - systemic immune-inflammation index (SII)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/06 06:00
MHDA- 2022/12/07 06:00
PMCR- 2022/01/01
CRDT- 2022/12/05 04:12
PHST- 2022/09/30 00:00 [received]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2022/12/05 04:12 [entrez]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.1058779 [doi]
PST - epublish
SO  - Front Immunol. 2022 Nov 18;13:1058779. doi: 10.3389/fimmu.2022.1058779. 
      eCollection 2022.