PMID- 36468410
OWN - NLM
STAT- MEDLINE
DCOM- 20230202
LR  - 20230203
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 37
IP  - 1
DP  - 2023 Jan
TI  - Progression of lipase activity and pancreatic lipase immunoreactivity in dogs 
      hospitalized for acute pancreatitis and correlation with clinical features.
PG  - 70-79
LID - 10.1111/jvim.16591 [doi]
AB  - BACKGROUND: Lipase activity and pancreatic lipase immunoreactivity (PLI) have not 
      been compared in dogs hospitalized for acute pancreatitis (AP). OBJECTIVES: To 
      describe the progression of lipase activity and PLI, and correlations with 
      clinicopathologic features in dogs with AP. ANIMALS: Thirty-nine dogs with AP 
      based on clinical signs and lipase activity >350 U/L (reference interval [RI], 
      24-108 U/L). METHODS: Retrospective study. Lipase activity (LIPC Roche), PLI 
      (SpecPL), and clinical signs were recorded daily. Admission (d1) data (clinical, 
      laboratory, and ultrasound [US] findings), and clinical signs during 
      hospitalization (d2-d3) were assessed for correlation with lipases. RESULTS: 
      Median (range) duration of clinical signs before presentation was 2 days 
      (1-7 days). Median (range) lipase activity and PLI at d1 were 1070 U/L (range, 
      357-1500 U/L) and 1111 mug/L (range, 292-1500 mug/L). Strong correlation between 
      assays at d1 (r(s) 0.96; P < .0001; n = 39), remained equally strong on d2 (r(s) 
      0.964; P < .0001; n = 39), and d3 (r(s) 0.966; P < .0001; n = 22). On d2, lipase 
      activity and PLI were within RI in 13/39 (33%) and 18/39 (46%) of cases. Lipase 
      activities were minimally increased (median, 124 U/L) in 5 dogs with d2 PLI 
      <200 mug/L. On d3, 4 more dogs had normal lipase activity and PLI, and the nature 
      and magnitude of change were always the same for both assays. Clinical signs were 
      not associated with lipases. Only a hyperechoic mesentery, but not an US 
      diagnosis of AP, correlated significantly with lipase activity and PLI. 
      CONCLUSIONS AND CLINICAL IMPORTANCE: Lipase decreases rapidly to near or within 
      RI within 2 days of treatment in the majority of dogs with AP. Both lipase assays 
      yielded virtually identical results. Mesenteric echogenicity may be an early 
      marker of AP in dogs.
CI  - (c) 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
FAU - Cueni, Claudia
AU  - Cueni C
AD  - Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of 
      Zurich, Zurich, Switzerland.
FAU - Hofer-Inteeworn, Natalie
AU  - Hofer-Inteeworn N
AD  - Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of 
      Zurich, Zurich, Switzerland.
FAU - Kummerle-Fraune, Claudia
AU  - Kummerle-Fraune C
AD  - Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of 
      Zurich, Zurich, Switzerland.
FAU - Muller, Claudia
AU  - Muller C
AD  - Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of 
      Zurich, Zurich, Switzerland.
FAU - Kook, Peter Hendrik
AU  - Kook PH
AUID- ORCID: 0000-0002-9492-3484
AD  - Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of 
      Zurich, Zurich, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20221205
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - EC 3.1.1.3 (Lipase)
SB  - IM
MH  - Dogs
MH  - Animals
MH  - *Pancreatitis/veterinary/diagnosis
MH  - Retrospective Studies
MH  - Lipase
MH  - Acute Disease
MH  - *Dog Diseases/diagnostic imaging
MH  - Pancreas/diagnostic imaging
PMC - PMC9889606
OTO - NOTNLM
OT  - DGGR
OT  - PLI
OT  - Spec cPL
OT  - dog
OT  - lipase activity
OT  - pancreatic ultrasonography
OT  - pancreatitis
COIS- Authors declare no conflict of interest.
EDAT- 2022/12/06 06:00
MHDA- 2023/02/03 06:00
PMCR- 2022/12/05
CRDT- 2022/12/05 05:03
PHST- 2022/07/16 00:00 [received]
PHST- 2022/11/16 00:00 [accepted]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2023/02/03 06:00 [medline]
PHST- 2022/12/05 05:03 [entrez]
PHST- 2022/12/05 00:00 [pmc-release]
AID - JVIM16591 [pii]
AID - 10.1111/jvim.16591 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2023 Jan;37(1):70-79. doi: 10.1111/jvim.16591. Epub 2022 Dec 5.