PMID- 36468957
OWN - NLM
STAT- MEDLINE
DCOM- 20221207
LR  - 20221207
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 21
IP  - 12
DP  - 2022 Dec 1
TI  - A Topical Combination Regimen of Benzoyl Peroxide and Retinol Moisturizer for 
      Mild to Moderate Acne.
PG  - 1340-1346
LID - 10.36849/JDD.6845 [doi]
AB  - Topical therapies, in many cases over-the-counter (OTC) formulations, are 
      available for the treatment of acne, including benzoyl peroxide (BPO), salicylic 
      acid, and retinoids. While these agents provide therapeutic efficacy, combination 
      regimens can offer improved outcomes due to their ability to address multiple 
      pathways involved in acne formation, making them better suited to address the 
      multiple factors involved in acne pathogenesis and the breadth of complexion 
      issues associated with the condition. The present study assessed the efficacy and 
      tolerability of a daily regimen comprised of topical low-dose (2.5%) BPO applied 
      in the morning and topical retinol applied in the evening in 33 subjects with 
      mild to moderate acne who completed the study. A significant reduction in global 
      total acne count from baseline to week 12 (primary endpoint) was achieved, in 
      addition to significant improvements in Investigator Global Assessment (IGA) of 
      acne severity and reductions in inflammatory and non-inflammatory lesions. 
      Treatment also significantly improved acne-complexion graded efficacy parameters 
      (tactile surface roughness, uneven skin tone, skin blotchiness, and lack of skin 
      clarity), and was well-tolerated, with no statistically significant (P<0.05) 
      increases in objective or subjective facial irritation. Significant improvements 
      from baseline to week 12 were observed for both self-assessment of facial skin 
      conditions and quality of life (QoL) scores. No product-related adverse events 
      (AEs) were observed in the study subjects. J Drugs Dermatol. 
      2022;21(12):1340-1346. doi:10.36849/JDD.6845.
FAU - Kosmoski, Gabrielle
AU  - Kosmoski G
FAU - Miller, Dara
AU  - Miller D
FAU - Coret, Catherine
AU  - Coret C
FAU - Atillasoy, Evren
AU  - Atillasoy E
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - W9WZN9A0GM (Benzoyl Peroxide)
RN  - 11103-57-4 (Vitamin A)
RN  - 0 (Dermatologic Agents)
RN  - 0 (Nonprescription Drugs)
RN  - 0 (Gels)
RN  - 0 (Drug Combinations)
SB  - IM
MH  - Humans
MH  - Benzoyl Peroxide
MH  - Quality of Life
MH  - Vitamin A/adverse effects
MH  - *Dermatologic Agents
MH  - *Acne Vulgaris/diagnosis/drug therapy/chemically induced
MH  - Nonprescription Drugs/therapeutic use
MH  - Gels/therapeutic use
MH  - Treatment Outcome
MH  - Drug Combinations
MH  - Administration, Cutaneous
EDAT- 2022/12/06 06:00
MHDA- 2023/02/25 06:00
CRDT- 2022/12/05 10:08
PHST- 2022/12/05 10:08 [entrez]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
AID - S1545961622P1340X [pii]
AID - 10.36849/JDD.6845 [doi]
PST - ppublish
SO  - J Drugs Dermatol. 2022 Dec 1;21(12):1340-1346. doi: 10.36849/JDD.6845.