PMID- 36469259
OWN - NLM
STAT- MEDLINE
DCOM- 20230207
LR  - 20230207
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 50
IP  - 2
DP  - 2023 Feb
TI  - TGFbeta1 rs1800469 and SMAD4 rs10502913 polymorphisms and genetic susceptibility to 
      colorectal cancer in Bangladeshi population.
PG  - 1393-1401
LID - 10.1007/s11033-022-08146-x [doi]
AB  - BACKGROUND: Among Bangladeshi males and females, colorectal cancer is the fourth 
      and fifth most prevalent cancer, respectively. Several studies have shown that 
      the transforming growth factor beta 1 (TGFbeta1) gene and SMAD4 gene have a great 
      impact on colorectal cancer. OBJECTIVE: The present study aimed to investigate 
      whether TGFbeta1 rs1800469 and SMAD4 rs10502913 genetic polymorphisms are associated 
      with susceptibility to colorectal cancer in the Bangladeshi population. METHODS 
      AND MATERIALS: This case-control study was performed on 167 colorectal cancer 
      patients and 162 healthy volunteers, and polymerase chain reaction-restriction 
      fragment length polymorphism (PCR-RFLP) method was employed for genotyping. 
      RESULTS: In case of SMAD4 rs10502913 G > A polymorphism, the A allele reduced the 
      colorectal cancer risk significantly (adjusted OR 0.35, 95% CI 0.23-0.52, 
      p < 0.001) when compared to the G allele. It was also found that G/A and A/A 
      genotypes of SMAD4 rs10502913 G > A polymorphism reduced the risk of colorectal 
      cancer in comparison to the G/G genotype (G/A vs. G/G: adjusted OR 0.24, 95% 
      CI 0.12-0.45, p < 0.001 and A/A vs. G/G: adjusted OR 0.06, 95% CI 0.02-0.21, 
      p < 0.001). TGFbeta1 rs1800469 C > T polymorphism showed an elevated risk of 
      developing colorectal cancer, although the results were not statistically 
      significant. CONCLUSION: This study confirms the association of SMAD4 rs10502913 
      gene polymorphism with colorectal cancer susceptibility among the Bangladeshi 
      population.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Sultana, Taposhi Nahid
AU  - Sultana TN
AD  - Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University 
      of Dhaka, Dhaka, 1000, Bangladesh.
AD  - Department of Pharmacy, University of Asia Pacific, Dhaka, 1205, Bangladesh.
AD  - Department of Pharmacy, Independent University, Bangladesh, Dhaka, 1229, 
      Bangladesh.
FAU - Chaity, Nusrat Islam
AU  - Chaity NI
AD  - Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University 
      of Dhaka, Dhaka, 1000, Bangladesh.
FAU - Hasan, Md Mehedi
AU  - Hasan MM
AD  - Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University 
      of Dhaka, Dhaka, 1000, Bangladesh.
FAU - Shrabonee, Ishrat Islam
AU  - Shrabonee II
AD  - Department of Medicine, Mymensingh Medical College Hospital, Mymensingh, 2200, 
      Bangladesh.
FAU - Rivu, Sanzana Fareen
AU  - Rivu SF
AD  - Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University 
      of Dhaka, Dhaka, 1000, Bangladesh.
AD  - Department of Pharmacy, Faculty of Science and Engineering, East West University, 
      Dhaka, 1212, Bangladesh.
FAU - Aziz, Md Abdul
AU  - Aziz MA
AD  - Department of Pharmacy, Faculty of Pharmacy and Health Sciences, State University 
      of Bangladesh, Dhaka, 1205, Bangladesh.
AD  - Bangladesh Pharmacogenomics Research Network (BD-PGRN), Dhaka, Bangladesh.
FAU - Sahaba, Shaid All
AU  - Sahaba SA
AD  - Department of Pharmacy, Faculty of Pharmacy and Health Sciences, State University 
      of Bangladesh, Dhaka, 1205, Bangladesh.
FAU - Apu, Mohd Nazmul Hasan
AU  - Apu MNH
AD  - Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University 
      of Dhaka, Dhaka, 1000, Bangladesh.
FAU - Nahid, Noor Ahmed
AU  - Nahid NA
AD  - Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University 
      of Dhaka, Dhaka, 1000, Bangladesh.
FAU - Islam, Mohammad Safiqul
AU  - Islam MS
AUID- ORCID: 0000-0003-4924-5319
AD  - Department of Pharmacy, Faculty of Pharmacy, Noakhali Science and Technology 
      University, Noakhali, 3814, Bangladesh. research_safiq@nstu.edu.bd.
AD  - Bangladesh Pharmacogenomics Research Network (BD-PGRN), Dhaka, Bangladesh. 
      research_safiq@nstu.edu.bd.
FAU - Islam, Md Saiful
AU  - Islam MS
AD  - Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University 
      of Dhaka, Dhaka, 1000, Bangladesh.
LA  - eng
PT  - Journal Article
DEP - 20221205
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Smad4 Protein)
RN  - 0 (SMAD4 protein, human)
RN  - 0 (TGFB1 protein, human)
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Case-Control Studies
MH  - *Colorectal Neoplasms/genetics
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Smad4 Protein/genetics
OTO - NOTNLM
OT  - Association
OT  - Colorectal cancer
OT  - Polymorphisms
OT  - SMAD4
OT  - TGFbeta1
EDAT- 2022/12/06 06:00
MHDA- 2023/02/03 06:00
CRDT- 2022/12/05 11:22
PHST- 2022/07/25 00:00 [received]
PHST- 2022/11/22 00:00 [accepted]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2023/02/03 06:00 [medline]
PHST- 2022/12/05 11:22 [entrez]
AID - 10.1007/s11033-022-08146-x [pii]
AID - 10.1007/s11033-022-08146-x [doi]
PST - ppublish
SO  - Mol Biol Rep. 2023 Feb;50(2):1393-1401. doi: 10.1007/s11033-022-08146-x. Epub 
      2022 Dec 5.