PMID- 36469279
OWN - NLM
STAT- MEDLINE
DCOM- 20230207
LR  - 20230207
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 4
DP  - 2023 Jan
TI  - The role of polybrominated diphenyl ethers in the induction of cancer: a 
      systematic review of insight into their mechanisms.
PG  - 9271-9289
LID - 10.1007/s11356-022-24538-9 [doi]
AB  - Environmental pollution caused by persistent organic pollutants (POPs) has 
      increased the challenge for the scientific communities. Polybrominated diphenyl 
      ethers (PBDEs), classified as POPs, are widely applied in various materials as 
      brominated flame retardants (BFRs). Because of the nature of these chemical 
      compounds including toxicity, stability, and capability to bioaccumulate and 
      biomagnify, PBDEs have posed a great challenge and risk to human health and 
      wildlife. Therefore, the side effects of exposure to PBDEs as ubiquitous 
      pollutants in the environment on cancer progression were investigated using a 
      systematic review (SR) survey. To achieve this goal, forty studies were 
      considered after defining the search terms and inclusion criteria, and/or 
      exclusion criteria; the eligible records were collected from the international 
      bibliographic databases. Based on the findings of the reviewed records, 
      environmental exposure to the BFRs including PBDEs has a positive association 
      with different mechanisms that induce cancer progression. However, the findings 
      of the reviewed studies were not totally consistent with the mode of action and 
      side effects are yet to be fully elucidated. Several articles have reported that 
      BFRs can be carcinogenic and induce epithelial to mesenchymal transition via 
      different mechanisms. The main mode of action involved in the environmental 
      exposure to BFRs and the risk of cancer progression is endoplasmic reticulum and 
      oxidative stress (OS). Generally, the imbalance of antioxidant mechanisms, 
      reactive nitrogen species (RNSs) and reactive oxygen species (ROSs), during 
      damage in cells, and stress caused OS, which increases tumorigenesis via multiple 
      mechanisms, such as DNA damage, inflammation, and angiogenesis.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Azizi, Mahdieh
AU  - Azizi M
AD  - Department of Immunology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Mami, Sanaz
AU  - Mami S
AD  - Department of Immunology, School of Medicine, Ilam University of Medical 
      Sciences, Ilam, Iran.
FAU - Noorimotlagh, Zahra
AU  - Noorimotlagh Z
AD  - Health and Environment Research Center, Ilam University of Medical Sciences, 
      Ilam, Iran.
AD  - Department of Environmental Health Engineering, Faculty of Health, Ilam 
      University of Medical Sciences, Ilam, Iran.
FAU - Mirzaee, Seyyed Abbas
AU  - Mirzaee SA
AUID- ORCID: 0000-0001-6100-7431
AD  - Health and Environment Research Center, Ilam University of Medical Sciences, 
      Ilam, Iran. mirzaee.seyyed@gmail.com.
AD  - Department of Environmental Health Engineering, Faculty of Health, Ilam 
      University of Medical Sciences, Ilam, Iran. mirzaee.seyyed@gmail.com.
FAU - Silva Martinez, Susana
AU  - Silva Martinez S
AD  - Centro de Investigacion en Ingenieria Y Ciencias Aplicadas, Universidad Autonoma 
      del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, 62210, Cuernavaca, 
      Morelos, Mexico.
FAU - Bazgir, Nasrin
AU  - Bazgir N
AD  - Non-Communicable Diseases Research Center, Ilam University of Medical Sciences, 
      Ilam, Iran.
AD  - Department of Rheumatology, Faculty of Medicine, Ilam University of Medical 
      Sciences, Ilam, Iran.
LA  - eng
GR  - Grant No:401H003/22/Ilam University of Medical Sciences/
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20221205
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
SB  - IM
MH  - Humans
MH  - Halogenated Diphenyl Ethers/analysis
MH  - Epithelial-Mesenchymal Transition
MH  - Environmental Exposure
MH  - *Environmental Pollutants/toxicity
MH  - *Flame Retardants/analysis
MH  - Carcinogenesis
MH  - Environmental Monitoring
OTO - NOTNLM
OT  - Brominated flame retardants
OT  - Cancer progression
OT  - Environmental exposure
OT  - Oxidative stress
OT  - Persistent organic pollutants
OT  - Polybrominated diphenyl ethers
EDAT- 2022/12/06 06:00
MHDA- 2023/02/08 06:00
CRDT- 2022/12/05 11:22
PHST- 2022/09/04 00:00 [received]
PHST- 2022/11/25 00:00 [accepted]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2023/02/08 06:00 [medline]
PHST- 2022/12/05 11:22 [entrez]
AID - 10.1007/s11356-022-24538-9 [pii]
AID - 10.1007/s11356-022-24538-9 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Jan;30(4):9271-9289. doi: 
      10.1007/s11356-022-24538-9. Epub 2022 Dec 5.