PMID- 36469745
OWN - NLM
STAT- MEDLINE
DCOM- 20230130
LR  - 20230322
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 46
IP  - 2
DP  - 2023 Feb 1
TI  - Physical Activity Changes and the Risk of Incident Atrial Fibrillation in 
      Patients With Type 2 Diabetes Mellitus: A Nationwide Longitudinal Follow-up 
      Cohort Study of 1.8 Million Subjects.
PG  - 434-440
LID - 10.2337/dc22-1655 [doi]
AB  - OBJECTIVE: We investigated the association between alterations in regular 
      physical activity (PA) and the risk of developing AF in patients with type 2 
      diabetes mellitus (T2DM) and the optimal PA range based on energy expenditure. 
      RESEARCH DESIGN AND METHODS: In a nationwide database, subjects who underwent 
      health examinations twice at a 2-year interval between 2009 and 2012 were 
      studied. After 1,815,330 patients with T2DM who did not have a history of AF were 
      identified, they were followed until 2018. Regular PA alterations over time were 
      used to divide individuals into four groups: persistent nonexercisers (n = 
      1,181,837), new exercisers (n = 242,968), exercise dropouts (n = 225,124), and 
      exercise maintainers (n = 165,401). RESULTS: During a mean follow-up period of 
      5.6 +/- 1.3 years, 46,589 cases (2.6%) of new-onset AF occurred. Compared with the 
      persistent nonexerciser group, both the exercise dropout group (adjusted hazard 
      ratio [HR] 0.96, 95% CI 0.94-0.99) and new exerciser group (HR 0.95, 95% CI 
      0.93-0.98) had lower risks of incident AF. The exercise maintainer group showed 
      the lowest risk (HR 0.91, 95% CI 0.89-0.94). When we stratified patients with 
      T2DM according to energy expenditure, undergoing regular PA with >/=1,500 
      MET-min/week in new exercisers and >/=1,000 MET-min/week in exercise maintainers 
      was associated with lower risks of incident AF than nonexercisers. CONCLUSIONS: 
      In patients with T2DM, starting and maintaining regular PA were both associated 
      with lower risk of incident AF. Optimal PA ranges based on energy expenditure, 
      which were associated with lower risks of incident AF, can be defined.
CI  - (c) 2023 by the American Diabetes Association.
FAU - Park, Chan Soon
AU  - Park CS
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Choi, Eue-Keun
AU  - Choi EK
AUID- ORCID: 0000-0002-0411-6372
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea.
FAU - Kyung-DoHan
AU  - Kyung-DoHan
AD  - Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
FAU - Yoo, Juhwan
AU  - Yoo J
AD  - Department of Biomedicine & Health Science, The Catholic University of Korea, 
      Seoul, Republic of Korea.
FAU - Ahn, Hyo-Jeong
AU  - Ahn HJ
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Kwon, Soonil
AU  - Kwon S
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Lee, So-Ryoung
AU  - Lee SR
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
FAU - Oh, Seil
AU  - Oh S
AD  - Division of Cardiology, Department of Internal Medicine, Seoul National 
      University Hospital, Seoul, Republic of Korea.
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea.
FAU - Lip, Gregory Y H
AU  - Lip GYH
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Republic of Korea.
AD  - Liverpool Centre for Cardiovascular Science, University of Liverpool and 
      Liverpool Chest and Heart Hospital, Liverpool, U.K.
AD  - Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Humans
MH  - Follow-Up Studies
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Atrial Fibrillation/epidemiology
MH  - Risk Factors
MH  - Incidence
MH  - Exercise
EDAT- 2022/12/06 06:00
MHDA- 2023/01/31 06:00
CRDT- 2022/12/05 15:12
PHST- 2022/08/23 00:00 [received]
PHST- 2022/11/02 00:00 [accepted]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2023/01/31 06:00 [medline]
PHST- 2022/12/05 15:12 [entrez]
AID - 148027 [pii]
AID - 10.2337/dc22-1655 [doi]
PST - ppublish
SO  - Diabetes Care. 2023 Feb 1;46(2):434-440. doi: 10.2337/dc22-1655.