PMID- 36469971
OWN - NLM
STAT- MEDLINE
DCOM- 20230110
LR  - 20230404
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 37
IP  - 1
DP  - 2023 Jan
TI  - Diabetic microvascular complications are associated with left atrial structural 
      alterations in asymptomatic type 2 diabetes patients: A cross-sectional study.
PG  - 108361
LID - S1056-8727(22)00273-2 [pii]
LID - 10.1016/j.jdiacomp.2022.108361 [doi]
AB  - AIMS: We used 4D-Auto LAQ to quantitatively evaluate the morphological and 
      functional changes of left atrium in patients with asymptomatic type 2 diabetes 
      mellitus (T2DM), and explored its correlations with diabetic microvascular 
      complications (MICRO). METHODS: This study included 319 patients with 
      asymptomatic T2DM. According to the occurrence of MICRO, these patients were 
      divided into 3 groups: patients with no complication, 1 complication, and 2-3 
      complications. 4D-Auto LAQ was used to evaluate left atrial volume (LAVImin, 
      LAVImax, LAVIpre) and calculate the left atrial function (DEI, PEI, AEI) in 
      different phases. Multiple linear regression was used to analyze the correlation 
      between changes in left atrial volume and function and the number of MICROs in DM 
      patients. RESULTS: A total of 279 patients with asymptomatic T2DM were included 
      in this study. (1) The ultrasound data of the three T2DM groups showed that there 
      was no significant difference in left ventricular size and function among the 
      three groups; (2) with the increase of MICRO number, the left atrial volume 
      (LAVImin, LAVImax, LAVIpre) progressively increased, the left atrial storage 
      function index (DEI) gradually decreased, and the differences were significant 
      (P < 0.05). (3) Multiple linear regression analysis showed that: with the 
      increase of MICRO number (no complication-->1 complication-->2-3 complications), the 
      left atrial volume (LAVImin, LAVIpre) showed an increasing trend (both P < 0.05). 
      CONCLUSION: In asymptomatic T2DM patients, MICRO number showed a significant 
      positive correlation with LAVImin and LAVIpre (P < 0.05). Therefore, the increase 
      in left atrial volume can dynamically reflect the severity of microvascular 
      lesions in patients with asymptomatic T2DM.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Gong, Mingxia
AU  - Gong M
AD  - Department of Echocardiography of The Third Affiliated Hospital of Soochow 
      University, Chang Zhou City, Jiangsu Province, China.
FAU - Xu, Min
AU  - Xu M
AD  - Department of Echocardiography of The Third Affiliated Hospital of Soochow 
      University, Chang Zhou City, Jiangsu Province, China. Electronic address: 
      loisicelin@163.com.
FAU - Meng, Jun
AU  - Meng J
AD  - Department of Echocardiography of The Third Affiliated Hospital of Soochow 
      University, Chang Zhou City, Jiangsu Province, China.
FAU - Jiang, Shu
AU  - Jiang S
AD  - Department of Echocardiography of The Third Affiliated Hospital of Soochow 
      University, Chang Zhou City, Jiangsu Province, China.
FAU - Jiang, Xiaohong
AU  - Jiang X
AD  - Department of Endocrinology of The Third Affiliated Hospital of Soochow 
      University, Chang Zhou City, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221130
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Cross-Sectional Studies
MH  - *Atrial Fibrillation/complications
MH  - Heart Atria/diagnostic imaging
MH  - *Diabetic Angiopathies/diagnostic imaging/epidemiology/etiology
OTO - NOTNLM
OT  - 4D-ultrasound
OT  - Left atrial volume
OT  - Microvascular complications
OT  - Type 2 diabetes
EDAT- 2022/12/06 06:00
MHDA- 2023/01/11 06:00
CRDT- 2022/12/05 18:04
PHST- 2022/07/08 00:00 [received]
PHST- 2022/11/22 00:00 [revised]
PHST- 2022/11/23 00:00 [accepted]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/12/05 18:04 [entrez]
AID - S1056-8727(22)00273-2 [pii]
AID - 10.1016/j.jdiacomp.2022.108361 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2023 Jan;37(1):108361. doi: 
      10.1016/j.jdiacomp.2022.108361. Epub 2022 Nov 30.