PMID- 36470031
OWN - NLM
STAT- MEDLINE
DCOM- 20230201
LR  - 20230202
IS  - 1525-3171 (Electronic)
IS  - 0032-5791 (Print)
IS  - 0032-5791 (Linking)
VI  - 102
IP  - 2
DP  - 2023 Feb
TI  - Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent 
      chromium in broilers.
PG  - 102335
LID - S0032-5791(22)00629-0 [pii]
LID - 10.1016/j.psj.2022.102335 [doi]
LID - 102335
AB  - Hexavalent chromium (Cr(Ⅵ)) is considered to be a common environmental pollutant, 
      which widely exists in industrial effluents and wastes and then potentially 
      noxious effects to the health of the poultry. Studies have reported that selenium 
      (Se), which is one of the essential trace elements of the poultry and 
      participates in the oxidative metabolism, can alleviate Cr(Ⅵ)-induced organ 
      damage by inhibiting oxidative stress, but its specific molecular mechanism 
      remains unclear. Herein, animal models of Cr(Ⅵ)- and Se-exposure were constructed 
      using broilers to investigate the antagonistic mechanism of Se to Cr(Ⅵ)-induced 
      hepatotoxicity. In this experiment, the four groups of broiler models were used 
      as the research objects: control, Se, Se plus Cr, and Cr groups. Histopathology 
      and ultrastructure liver changes were observed. Liver-somatic index, serum 
      biochemistry, oxidative stress, Nrf2 pathway related factors, and 
      autophagy-related genes were also determined. Overall, Se was found to ameliorate 
      the disorganized structure, hepatic insufficiency, and oxidative damage caused by 
      Cr(Ⅵ) exposure. Electron microscopy analysis further showed that the number of 
      autophagosomes was obviously decreased after Se treatment compared to Cr group. 
      Furthermore, gene and protein expression analyses illustrated that the levels of 
      Nrf2, glutathione peroxidase 1 (GPx-1), NAD(P)H: quinone oxidoreductase 1 (NQO1), 
      and mechanistic target of rapamycin (mTOR) in the Se&Cr group was upregulated, 
      along with decreased expression of Beclin 1, ATG5 and LC3 compared to the Cr 
      group. These suggest that Se can repair the oxidative lesion and autophagy 
      induced by Cr(Ⅵ) exposure in broiler livers by upregulating the Nrf2 signaling 
      pathway.
CI  - Copyright (c) 2022. Published by Elsevier Inc.
FAU - Wang, Jingqiu
AU  - Wang J
AD  - College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong, 
      030801, P. R. China.
FAU - Liu, Ci
AU  - Liu C
AD  - College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong, 
      030801, P. R. China. Electronic address: liuci1988@163.com.
FAU - Zhao, Yanbing
AU  - Zhao Y
AD  - College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong, 
      030801, P. R. China.
FAU - Wang, Jinglu
AU  - Wang J
AD  - College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong, 
      030801, P. R. China.
FAU - Li, Jianhui
AU  - Li J
AD  - College of Animal Science, Shanxi Agricultural University, Taigu, Jinzhong, 
      030801, P. R. China.
FAU - Zheng, Mingxue
AU  - Zheng M
AD  - College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong, 
      030801, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20221112
PL  - England
TA  - Poult Sci
JT  - Poultry science
JID - 0401150
RN  - H6241UJ22B (Selenium)
RN  - 18540-29-9 (chromium hexavalent ion)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0R0008Q3JB (Chromium)
SB  - IM
MH  - Animals
MH  - *Selenium/pharmacology/metabolism
MH  - Chickens/metabolism
MH  - NF-E2-Related Factor 2/genetics/metabolism
MH  - Chromium/toxicity/metabolism
MH  - Oxidative Stress
MH  - *Chemical and Drug Induced Liver Injury/prevention & control/veterinary
MH  - Signal Transduction
PMC - PMC9719864
OTO - NOTNLM
OT  - Nrf2 signaling pathway
OT  - autophagy
OT  - hepatotoxicity
OT  - hexavalent chromium
OT  - selenium
EDAT- 2022/12/06 06:00
MHDA- 2023/02/02 06:00
PMCR- 2022/11/12
CRDT- 2022/12/05 18:17
PHST- 2022/04/11 00:00 [received]
PHST- 2022/11/05 00:00 [revised]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2023/02/02 06:00 [medline]
PHST- 2022/12/05 18:17 [entrez]
PHST- 2022/11/12 00:00 [pmc-release]
AID - S0032-5791(22)00629-0 [pii]
AID - 102335 [pii]
AID - 10.1016/j.psj.2022.102335 [doi]
PST - ppublish
SO  - Poult Sci. 2023 Feb;102(2):102335. doi: 10.1016/j.psj.2022.102335. Epub 2022 Nov 
      12.