PMID- 36470339
OWN - NLM
STAT- MEDLINE
DCOM- 20230203
LR  - 20230225
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 84
DP  - 2023 Feb
TI  - Arterial myogenic response and aging.
PG  - 101813
LID - S1568-1637(22)00255-0 [pii]
LID - 10.1016/j.arr.2022.101813 [doi]
AB  - The arterial myogenic response is an inherent property of resistance arteries. 
      Myogenic tone is crucial for maintaining a relatively constant blood flow in 
      response to changes in intraluminal pressure and protects delicate organs from 
      excessive blood flow. Although this fundamental physiological phenomenon has been 
      extensively studied, the underlying molecular mechanisms are largely unknown. 
      Recent studies identified a crucial role of mechano-activated angiotensin II type 
      1 receptors (AT1R) in this process. The development of myogenic response is 
      affected by aging. In this review, we summarize recent progress made to 
      understand the role of AT1R and other mechanosensors in the control of arterial 
      myogenic response. We discuss age-related alterations in myogenic response and 
      possible underlying mechanisms and implications for healthy aging.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Cui, Yingqiu
AU  - Cui Y
AD  - Charite - Universitatsmedizin Berlin, Experimental and Clinical Research Center 
      (ECRC), a joint cooperation between the Charite Medical Faculty and the Max 
      Delbruck Center for Molecular Medicine (MDC), Lindenberger Weg 80, 13125 Berlin, 
      Germany.
FAU - Gollasch, Maik
AU  - Gollasch M
AD  - Department of Internal Medicine and Geriatrics, University Medicine Greifswald, 
      Felix-Hausdorff-Strasse 3, 17487 Greifswald, Germany.
FAU - Kassmann, Mario
AU  - Kassmann M
AD  - Department of Internal Medicine and Geriatrics, University Medicine Greifswald, 
      Felix-Hausdorff-Strasse 3, 17487 Greifswald, Germany. Electronic address: 
      mario.kassmann@med.uni-greifswald.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20221205
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - Animals
MH  - Humans
MH  - Mice
MH  - *Arteries/metabolism/physiology
MH  - Mice, Knockout
MH  - *Aging/metabolism/pathology
OTO - NOTNLM
OT  - Aging
OT  - Ion channels
OT  - Myogenic response
OT  - Vascular smooth muscle
COIS- Declaration of Competing Interest The authors declare no competing interests.
EDAT- 2022/12/06 06:00
MHDA- 2023/01/11 06:00
CRDT- 2022/12/05 19:23
PHST- 2022/08/05 00:00 [received]
PHST- 2022/11/21 00:00 [revised]
PHST- 2022/11/29 00:00 [accepted]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2023/01/11 06:00 [medline]
PHST- 2022/12/05 19:23 [entrez]
AID - S1568-1637(22)00255-0 [pii]
AID - 10.1016/j.arr.2022.101813 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2023 Feb;84:101813. doi: 10.1016/j.arr.2022.101813. Epub 2022 Dec 
      5.