PMID- 36470361
OWN - NLM
STAT- MEDLINE
DCOM- 20230119
LR  - 20230119
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 313
DP  - 2023 Feb
TI  - Do changes in persistent organic pollutants after bariatric surgery cause 
      endocrine disruption?
PG  - 137461
LID - S0045-6535(22)03954-6 [pii]
LID - 10.1016/j.chemosphere.2022.137461 [doi]
AB  - BACKGROUND: Bariatric surgery results in weight loss, marked endocrine changes 
      and the release of persistent organic pollutants (POPs). The release of POPs 
      might cause endocrine disruption. The study aimed to explore associations between 
      POPs and adiponectin, leptin and ghrelin in subjects undergoing bariatric 
      surgery. METHODS: The study included 63 subjects with severe obesity (men/women: 
      13/50), age (years): 45.0 (8.5), and BMI (kg/m(2)) 39.1 (3.4). Analyses of 
      adiponectin, leptin and ghrelin and POPs (hexachlorobenzene (HCB), 
      dichlorodiphenyldichloroethylene (p,p'-DDE), polychlorinated biphenyl (PCB) 118 
      (dioxin-like compound; dl), and sum 6 PCB (PCB 28, -52, -101, -138, -153, and 
      -180) were performed before and 12 months after bariatric surgery. RESULTS: There 
      were significant increases in adiponectin and all POPs and a fall in leptin after 
      surgery. The main finding was the highly significant associations between 
      adiponectin and all POPs. The increase in HCB explained 38% of the variation in 
      adiponectin. CONCLUSIONS: If the POP-associated increase in adiponectin is a 
      causal effect, the release of POPs might have important clinical consequences. 
      Adiponectin has both positive and negative clinical effects exerted by 
      essentially unknown mechanisms. The effects of released POPs on the metabolic 
      functions in subjects undergoing bariatric surgery deserve further evaluation.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Jansen, Aina
AU  - Jansen A
AD  - Department of Surgery, Innlandet Hospital Trust, N-2819 Gjovik, Norway.
FAU - Aaseth, Jan O
AU  - Aaseth JO
AD  - Department of Research, Innlandet Hospital Trust, N-2381Brumunddal, Norway; 
      Faculty of Health and Social Sciences, Inland Norway University of Applied 
      Sciences, N-2418 Elverum, Norway.
FAU - Lyche, Jan L
AU  - Lyche JL
AD  - Department of Paraclinical Sciences, Norwegian University of Life Sciences 
      (NMBU), N-1433 As, Norway.
FAU - Berg, Jens P
AU  - Berg JP
AD  - Department of Medical Biochemistry, Oslo University Hospital, N-0450 Oslo, 
      Norway; Institute of Clinical Medicine, University of Oslo, N-0316 Oslo, Norway.
FAU - Muller, Mette H B
AU  - Muller MHB
AD  - Section for Experimental Biomedicine, Norwegian University of Life Sciences 
      (NMBU), N-1433 As, Norway.
FAU - Lydersen, Stian
AU  - Lydersen S
AD  - Regional Centre for Child and Youth Mental Health and Child Welfare, Department 
      of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University 
      of Science and Technology, N-7491 Trondheim, Norway.
FAU - Farup, Per G
AU  - Farup PG
AD  - Department of Research, Innlandet Hospital Trust, N-2381Brumunddal, Norway; 
      Department of Clinical and Molecular Medicine, Faculty of Medicine and Health 
      Sciences, Norwegian University of Science and Technology, N-7491Trondheim, 
      Norway. Electronic address: Per.Farup@ntnu.no.
LA  - eng
PT  - Journal Article
DEP - 20221202
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Adiponectin)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Ghrelin)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Leptin)
RN  - 0 (Persistent Organic Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Female
MH  - Humans
MH  - Male
MH  - Adiponectin
MH  - *Bariatric Surgery
MH  - Dichlorodiphenyl Dichloroethylene
MH  - Environmental Exposure/analysis
MH  - *Environmental Pollutants
MH  - Ghrelin
MH  - Hexachlorobenzene
MH  - *Hydrocarbons, Chlorinated
MH  - Leptin
MH  - Persistent Organic Pollutants
MH  - *Polychlorinated Biphenyls
MH  - Middle Aged
OTO - NOTNLM
OT  - Adiponectin
OT  - Bariatric surgery
OT  - Endocrine disrupting chemicals
OT  - Ghrelin
OT  - Leptin
OT  - Obesity
OT  - Persistent organic pollutants
OT  - Weight loss
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/12/06 06:00
MHDA- 2023/01/12 06:00
CRDT- 2022/12/05 19:24
PHST- 2022/09/26 00:00 [received]
PHST- 2022/11/22 00:00 [revised]
PHST- 2022/12/01 00:00 [accepted]
PHST- 2022/12/06 06:00 [pubmed]
PHST- 2023/01/12 06:00 [medline]
PHST- 2022/12/05 19:24 [entrez]
AID - S0045-6535(22)03954-6 [pii]
AID - 10.1016/j.chemosphere.2022.137461 [doi]
PST - ppublish
SO  - Chemosphere. 2023 Feb;313:137461. doi: 10.1016/j.chemosphere.2022.137461. Epub 
      2022 Dec 2.