PMID- 36471364 OWN - NLM STAT- MEDLINE DCOM- 20221207 LR - 20221208 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 22 IP - 1 DP - 2022 Dec 6 TI - Higher magnesium levels are associated with better glycaemic control and diabetes remission post-bariatric surgery. PG - 303 LID - 10.1186/s12902-022-01210-4 [doi] LID - 303 AB - BACKGROUND: Low Magnesium (Mg) dietary intake has been associated with increased risk of type 2 diabetes mellitus (T2DM). Furthermore, in patients with T2DM, hypomagnesemia is associated with worst glycaemic control. Bariatric surgery (BS) remains the most effective treatment in severe obesity and also provides resolution/improvement of T2DM. Our aim is to evaluate the association between Mg supplementation post-BS and Mg serum levels with diabetes status after BS. METHODS: We performed an observational study on patients with obesity and T2DM who underwent BS. Data was assessed pre-BS and one-year post-BS. RESULTS: We included a total of 403 patients with T2DM. At baseline, 43.4% of the patients had Mg deficiency. Pre-BS, patients with Mg deficiency had poorer glycaemic control - HbA1c 7.2 +/- 1.6% vs 6.4 +/- 1.0% (p < 0.001), fasting plasma glucose 146.2 +/- 58.8 mg/dL vs 117.5 +/- 36.6 mg/dL (p < 0.001) and were under a greater number of anti-diabetic drugs 1.0 (IQR 0-2.0) vs 1.0 (IQR 0-1.0) (p = 0.002). These findings persisted at one-year post-BS. At the first-year post-BS, 58.4% of the patients had total remission of T2DM and 4.1% had partial remission. Patients without Mg deficiency at one-year post-BS had higher rates of total and partial remission. Higher serum Mg levels at baseline is an independent predictor of total T2DM remission (p < 0.0001). The optimal cut-off of baseline Mg to predict total T2DM remission was 1.50 mg/dL with a sensitivity of 73% and a specificity of 58% (area under ROC = 0.65). Patients that were under Mg supplementation post-BS had serum Mg values, glycaemic control and total remission of T2DM similar to patients non-supplemented. CONCLUSION: In patients with T2DM submitted to BS, higher Mg serum levels at baseline and 1-year after BS were associated with better glycaemic control and higher rates of total T2DM remission at the first year post-BS. CI - (c) 2022. The Author(s). FAU - Mm, Silva AU - Mm S AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. maria.manuell@hotmail.com. AD - Faculty of Medicine, University of Porto, Porto, Portugal. maria.manuell@hotmail.com. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. maria.manuell@hotmail.com. FAU - Js, Neves AU - Js N AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. AD - Departamento de Cirurgia E Fisiologia, Faculdade de Medicina da Universidade Do Porto, Alameda Prof. Hernani Monteiro, 4200-319, Porto, Portugal. FAU - M, Borges-Canha AU - M BC AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. AD - Departamento de Cirurgia E Fisiologia, Faculdade de Medicina da Universidade Do Porto, Alameda Prof. Hernani Monteiro, 4200-319, Porto, Portugal. FAU - Ap, Mendes AU - Ap M AD - Medical and Performance Department, Sporting Clube de Portugal, Estrada da Malhada de Meias, Barroca d'Alva, 2890-529, Lisboa, Portugal. FAU - Mj, Fonseca AU - Mj F AD - Institute of Public Health of the University of Porto (ISPUP), Porto, Portugal. FAU - F, Mendonca AU - F M AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. FAU - Mj, Ferreira AU - Mj F AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. FAU - D, Salazar AU - D S AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. FAU - J, Pedro AU - J P AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. FAU - V, Guerreiro AU - V G AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. FAU - E, Lau AU - E L AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. FAU - A, Varela AU - A V AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. FAU - P, Freitas AU - P F AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. FAU - D, Carvalho AU - D C AD - Servico de Endocrinologia, Diabetes E Metabolismo, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal. AD - Faculty of Medicine, University of Porto, Porto, Portugal. AD - Investigacao E Inovacao Em Saude (i3s), Faculdade de Medicina da Universidade Do Porto, Porto, Portugal. CN - CRIO group LA - eng PT - Journal Article PT - Observational Study DEP - 20221206 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - I38ZP9992A (Magnesium) RN - 0 (Glycated Hemoglobin A) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2 MH - Magnesium MH - Glycemic Control MH - *Bariatric Surgery MH - Obesity/complications MH - *Obesity, Morbid/complications/surgery MH - Treatment Outcome MH - *Magnesium Deficiency/complications MH - Remission Induction MH - Glycated Hemoglobin/analysis MH - Blood Glucose PMC - PMC9724332 OTO - NOTNLM OT - Bariatric surgery OT - Magnesium OT - Obesity OT - Type 2 diabetes mellitus COIS- The authors declare that they have no competing interests. EDAT- 2022/12/06 06:00 MHDA- 2023/02/25 06:00 PMCR- 2022/12/06 CRDT- 2022/12/05 23:56 PHST- 2022/03/10 00:00 [received] PHST- 2022/11/10 00:00 [accepted] PHST- 2022/12/05 23:56 [entrez] PHST- 2022/12/06 06:00 [pubmed] PHST- 2023/02/25 06:00 [medline] PHST- 2022/12/06 00:00 [pmc-release] AID - 10.1186/s12902-022-01210-4 [pii] AID - 1210 [pii] AID - 10.1186/s12902-022-01210-4 [doi] PST - epublish SO - BMC Endocr Disord. 2022 Dec 6;22(1):303. doi: 10.1186/s12902-022-01210-4.