PMID- 36472340
OWN - NLM
STAT- MEDLINE
DCOM- 20230329
LR  - 20230329
IS  - 1532-2335 (Electronic)
IS  - 1525-7770 (Linking)
VI  - 42
IP  - 5
DP  - 2023
TI  - TNF-alpha promoter variant (G-308A) is associated with susceptibility to P. 
      falciparum infection and severe malaria: a meta-analysis and trial sequential 
      analysis.
PG  - 381-397
LID - 10.1080/15257770.2022.2151622 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) plays an essential role in Plasmodium 
      falciparum infection, with lower levels associated with susceptibility to 
      infection and higher levels linked with organ failure in severe malaria. Genetic 
      polymorphisms in the promoter region of the TNF-alpha gene (G-308A and G-238A) affect 
      plasma TNF-alpha levels. Numerous case-control studies have been conducted to 
      determine the possible association between TNF-alpha polymorphisms and susceptibility 
      to malaria infection and clinical severity; however, the results are 
      inconsistent. Various databases such as Google Scholar, Science Direct, PubMed, 
      and Scopus were searched for relevant articles for the present meta-analysis. 
      Data were extracted from the eligible studies based on inclusion and exclusion 
      criteria. Meta-analysis was carried out with CMA v.3.3.070 software, and combined 
      odds ratio, 95% confidence interval, and p values were calculated. Further, a 
      trial sequential analysis was also performed to test whether enough number of 
      case and controls have been enrolled to date to draw a valid conclusion. Allele 
      (OR = 9.757, p value=.049) and heterozygous (OR = 8.98, p value=.016) comparison 
      model revealed the TNF-alpha G-308A variant as a susceptible genetic factor for P. 
      falciparum infection. Similarly, a significant association of TNF-alpha G-308A 
      polymorphism with P. falciparum malarial severity was also observed (A versus G: 
      OR = 1.761, p value = .000; and GG + GA versus GG: OR = 1.769, p value = .000). 
      However, no association of TNF-alpha (G-238A) polymorphism was observed with 
      infection and severity of P. falciparum or Plasmodium vivax malaria. TNF-alpha G-308A 
      variant is associated with susceptibility to P. falciparum infection and clinical 
      severity. However, further studies on different populations are required.
FAU - Sarangi, Surjyapratap
AU  - Sarangi S
AD  - P.G. Department of Biotechnology, Berhampur University, Berhampur, India.
FAU - Nahak, Suraj Kuamr
AU  - Nahak SK
AD  - P.G. Department of Biotechnology, Berhampur University, Berhampur, India.
FAU - Padhi, Sunali
AU  - Padhi S
AD  - P.G. Department of Biotechnology, Berhampur University, Berhampur, India.
FAU - Nayak, Nisha
AU  - Nayak N
AD  - P.G. Department of Biotechnology, Berhampur University, Berhampur, India.
FAU - Pradhan, Bidyutprabha
AU  - Pradhan B
AD  - P.G. Department of Biotechnology, Berhampur University, Berhampur, India.
FAU - Pati, Abhijit
AU  - Pati A
AD  - P.G. Department of Biotechnology, Berhampur University, Berhampur, India.
FAU - Panigrahi, Jogeswar
AU  - Panigrahi J
AD  - P.G. Department of Biotechnology, Berhampur University, Berhampur, India.
FAU - Panda, Aditya K
AU  - Panda AK
AUID- ORCID: 0000-0002-1192-1978
AD  - P.G. Department of Biotechnology, Berhampur University, Berhampur, India.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20221206
PL  - United States
TA  - Nucleosides Nucleotides Nucleic Acids
JT  - Nucleosides, nucleotides & nucleic acids
JID - 100892832
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - *Tumor Necrosis Factor-alpha/genetics
MH  - Genetic Predisposition to Disease
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - *Malaria/genetics
MH  - Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Plasmodium falciparum
OT  - TNF-alpha
OT  - association
OT  - gene polymorphism
OT  - meta-analysis
OT  - severe malaria
EDAT- 2022/12/07 06:00
MHDA- 2023/03/29 06:05
CRDT- 2022/12/06 07:23
PHST- 2023/03/29 06:05 [medline]
PHST- 2022/12/07 06:00 [pubmed]
PHST- 2022/12/06 07:23 [entrez]
AID - 10.1080/15257770.2022.2151622 [doi]
PST - ppublish
SO  - Nucleosides Nucleotides Nucleic Acids. 2023;42(5):381-397. doi: 
      10.1080/15257770.2022.2151622. Epub 2022 Dec 6.