PMID- 36472705
OWN - NLM
STAT- MEDLINE
DCOM- 20221223
LR  - 20221223
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 40
IP  - 1
DP  - 2022 Dec 6
TI  - Investigating the anti-tumoral effect of yarrow (Achillea milllefolium) on the 
      mice in which ehrlich solid tumor is created.
PG  - 42
LID - 10.1007/s12032-022-01917-3 [doi]
AB  - In this study, BALB/c mice with Ehrlich solid tumors were used to examine the 
      effect of Achillea millefolium L. (AM) extract on the Ehrlich ascites tumor (EAT) 
      model, which is one of the experimental cancer models. Also known as yarrow and 
      plant, AM has antioxidant, anti-inflammatory, antibacterial and antitumor 
      properties. In our study, 57 male BALB/c type mice, 8-10 weeks old, weighing 
      25-30 g, were used. Mice were divided into two groups. Ehrlich Solid Tumor group: 
      Negative Control Group (ENC), Positive Control Group (EPC), and Treatment Group 
      (TG) (TNCAM-200 mg/kg, TPCAM-400 mg/kg). EPC and TG were given to EAT cells. Each 
      EAT contained 1 x 106 (will be 6 out of 10: so:000000) EAT cells, 0.1 ml of 
      phosphate-buffered saline (PBS) was administered subcutaneously (s.c.) to the 
      nape of mice. Then It was awaited for solid tumor formation. AM extract was 
      administered intraperitoneally (i.p.) to TG for 17 days to mice. AM extract was 
      found to have a curative effect on areas of inflammation, bleeding, and necrosis 
      in treatment groups treated with AM extract alone. The treatment groups showed 
      nearly normal histological results compared to the positive control group. 
      According to the results, the TPCAM-400 mg/kg group had a more significant 
      histological impact than the TNCAM-200 mg/kg group. In terms of tumor growth, 
      tumor length, tumor volume, and tumor weight, AM extract did not show significant 
      effects. However, in the light of histological findings, promising results of AM 
      were observed in mice in which Ehrlich Solid Tumor was formed.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Bagci Uzun, Gokce
AU  - Bagci Uzun G
AUID- ORCID: 0000-0003-4992-6915
AD  - Department of Anatomy, Faculty of Medicine, Malatya Turgut Ozal University, 
      Malatya, Turkey.
FAU - Nisari, Mehtap
AU  - Nisari M
AUID- ORCID: 0000-0002-1126-7478
AD  - Department of Anatomy, Faculty of Medicine, Erciyes University, Kayseri, Turkey. 
      mehtapnisari@gmail.com.
FAU - Hanim Yay, Arzu
AU  - Hanim Yay A
AUID- ORCID: 0000-0002-0541-8372
AD  - Department of Histology, Faculty of Medicine, Erciyes University, Kayseri, 
      Turkey.
FAU - Seker Karatoprak, Gokce
AU  - Seker Karatoprak G
AUID- ORCID: 0000-0001-5829-6914
AD  - Department of Pharmacy, Erciyes University Faculty Pharmacy, Kayseri, Turkey.
FAU - Al, Ozge
AU  - Al O
AUID- ORCID: 0000-0001-5292-3593
AD  - Department of Anatomy, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
FAU - Ucar, Sumeyye
AU  - Ucar S
AUID- ORCID: 0000-0003-3378-3745
AD  - Department of Anatomy, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
FAU - Arslan, Ayla
AU  - Arslan A
AUID- ORCID: 0000-0001-5859-7784
AD  - Department of Anatomy, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20221206
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Neoplasms
OTO - NOTNLM
OT  - Antitumoral
OT  - Ehrlich Solid Tumor
OT  - Yarrow
EDAT- 2022/12/07 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/12/06 11:15
PHST- 2022/10/20 00:00 [received]
PHST- 2022/11/22 00:00 [accepted]
PHST- 2022/12/06 11:15 [entrez]
PHST- 2022/12/07 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
AID - 10.1007/s12032-022-01917-3 [pii]
AID - 10.1007/s12032-022-01917-3 [doi]
PST - epublish
SO  - Med Oncol. 2022 Dec 6;40(1):42. doi: 10.1007/s12032-022-01917-3.