PMID- 36473200
OWN - NLM
STAT- MEDLINE
DCOM- 20221221
LR  - 20230107
IS  - 2151-3228 (Electronic)
IS  - 2151-321X (Linking)
VI  - 35
IP  - 4
DP  - 2022 Dec
TI  - Evaluation Value of Allergy in Adenoid Hypertrophy Through Blood Inflammatory 
      Cells and Total Immunoglobulin E.
PG  - 139-144
LID - 10.1089/ped.2022.0114 [doi]
AB  - Objective: Previous reports have indicated the close association of allergy with 
      adenoid hypertrophy (AH). The aim of this study was to evaluate whether the 
      inflammatory cells and total immunoglobulin E (IgE) in blood could be useful in 
      the diagnosis of allergy in AH. Methods: Two hundred thirty-four children who 
      underwent adenoidectomy were retrospectively enrolled in this study. Blood 
      routine parameters were recorded, and total IgE as well as specific IgE (sIgE) of 
      common allergens were tested perioperatively. The diagnostic utility of blood 
      inflammatory cells and total IgE compared with serum sIgE testing was assessed. 
      Results: In our study, 35.47% of AH children were atopic. Dermatophagoides 
      farinae (d2), Dermatophagoides pteronyssinus (d1), and mold (mx2) were the most 
      common sensitizing allergens. Significantly elevated eosinophil count, eosinophil 
      to lymphocyte value, and total IgE were found in allergic AH children. As a 
      result of receiver operating characteristic analysis, systemic total IgE could be 
      a method to diagnose allergy in AH with a cutoff value of 46.55 and higher (area 
      under curve [AUC] = 0.837; P < 0.001). Peripheral eosinophil count and eosinophil 
      to lymphocyte were also able to predict positive allergy test result in AH 
      children, with a cutoff value of 0.295 (AUC = 0.721; P < 0.001) and 0.082 
      (AUC = 0.685; P < 0.001), respectively. Conclusion: The presence of allergy can 
      be distinguished by looking at peripheral total IgE and/or blood eosinophils in 
      AH, which will guide us to the precise treatment of AH and also reduce the cost 
      considerably.
FAU - Zhang, Hailing
AU  - Zhang H
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      People's Republic of China.
FAU - Sun, Yanliang
AU  - Sun Y
AD  - Department of Otolaryngology, Ningjin County People's Hospital, Dezhou, People's 
      Republic of China.
FAU - Shen, Chaofan
AU  - Shen C
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      People's Republic of China.
FAU - Jin, Peng
AU  - Jin P
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      People's Republic of China.
FAU - Yue, Wei
AU  - Yue W
AD  - Department of Otolaryngology, Liaocheng Dongchangfu People's Hospital, Liaocheng, 
      People's Republic of China.
FAU - Zhang, Qinqin
AU  - Zhang Q
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      People's Republic of China.
FAU - Zhu, Fengjuan
AU  - Zhu F
AD  - Department of Otolaryngology-Head and Neck Surgery, The People's Hospital of 
      Rizhao, Rizhao, People's Republic of China.
FAU - Zhang, Hongping
AU  - Zhang H
AD  - Department of Otolaryngology, The Second Hospital of Shandong University, Jinan, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221206
PL  - United States
TA  - Pediatr Allergy Immunol Pulmonol
JT  - Pediatric allergy, immunology, and pulmonology
JID - 101549629
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Allergens)
SB  - IM
MH  - Child
MH  - Humans
MH  - Immunoglobulin E
MH  - *Adenoids
MH  - Retrospective Studies
MH  - *Hypersensitivity
MH  - Allergens
MH  - Hypertrophy
OTO - NOTNLM
OT  - IgE
OT  - adenoid hypertrophy
OT  - allergy
OT  - inflammation
OT  - laboratory
EDAT- 2022/12/07 06:00
MHDA- 2022/12/22 06:00
CRDT- 2022/12/06 17:13
PHST- 2022/12/07 06:00 [pubmed]
PHST- 2022/12/22 06:00 [medline]
PHST- 2022/12/06 17:13 [entrez]
AID - 10.1089/ped.2022.0114 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol Pulmonol. 2022 Dec;35(4):139-144. doi: 
      10.1089/ped.2022.0114. Epub 2022 Dec 6.