PMID- 36473469
OWN - NLM
STAT- MEDLINE
DCOM- 20221216
LR  - 20230119
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
VI  - 55
IP  - 12
DP  - 2022 Dec 13
TI  - Allergenic food protein consumption is associated with systemic IgG antibody 
      responses in non-allergic individuals.
PG  - 2454-2469.e6
LID - S1074-7613(22)00594-5 [pii]
LID - 10.1016/j.immuni.2022.11.004 [doi]
AB  - Although food-directed immunoglobulin E (IgE) has been studied in the context of 
      allergies, the prevalence and magnitude of IgG responses against dietary antigens 
      are incompletely characterized in the general population. Here, we measured IgG 
      binding against food and environmental antigens obtained from allergen databases 
      and the immune epitope database (IEDB), represented in a phage displayed library 
      of 58,233 peptides. By profiling blood samples of a large cohort representing the 
      average adult Israeli population (n = 1,003), we showed that many food antigens 
      elicited systemic IgG in up to 50% of individuals. Dietary intake of specific 
      food protein correlated with antibody binding, suggesting that diet can shape the 
      IgG epitope repertoire. Our work documents abundant systemic IgG responses 
      against food antigens and provides a reference map of the exact immunogenic 
      epitopes on a population scale, laying the foundation to unravel the role of 
      food- and environmental antigen-directed antibody binding in disease contexts.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Leviatan, Sigal
AU  - Leviatan S
AD  - Department of Computer Science and Applied Mathematics, Weizmann Institute of 
      Science, Rehovot, Israel; Department of Molecular Cell Biology, Weizmann 
      Institute of Science, Rehovot, Israel.
FAU - Vogl, Thomas
AU  - Vogl T
AD  - Department of Computer Science and Applied Mathematics, Weizmann Institute of 
      Science, Rehovot, Israel; Department of Molecular Cell Biology, Weizmann 
      Institute of Science, Rehovot, Israel; Diagnostic and Research Institute of 
      Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, 
      Graz, Austria; Center for Cancer Research, Medical University of Vienna, Wien, 
      Austria. Electronic address: thomas.vogl@meduniwien.ac.at.
FAU - Klompus, Shelley
AU  - Klompus S
AD  - Department of Computer Science and Applied Mathematics, Weizmann Institute of 
      Science, Rehovot, Israel; Department of Molecular Cell Biology, Weizmann 
      Institute of Science, Rehovot, Israel.
FAU - Kalka, Iris N
AU  - Kalka IN
AD  - Department of Computer Science and Applied Mathematics, Weizmann Institute of 
      Science, Rehovot, Israel; Department of Molecular Cell Biology, Weizmann 
      Institute of Science, Rehovot, Israel.
FAU - Weinberger, Adina
AU  - Weinberger A
AD  - Department of Computer Science and Applied Mathematics, Weizmann Institute of 
      Science, Rehovot, Israel; Department of Molecular Cell Biology, Weizmann 
      Institute of Science, Rehovot, Israel.
FAU - Segal, Eran
AU  - Segal E
AD  - Department of Computer Science and Applied Mathematics, Weizmann Institute of 
      Science, Rehovot, Israel; Department of Molecular Cell Biology, Weizmann 
      Institute of Science, Rehovot, Israel. Electronic address: 
      eran.segal@weizmann.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221205
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Allergens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Epitopes)
RN  - 0 (Dietary Proteins)
SB  - IM
MH  - Humans
MH  - *Allergens
MH  - Immunoglobulin G
MH  - Antibody Formation
MH  - *Food Hypersensitivity
MH  - Epitopes
MH  - Dietary Proteins
OTO - NOTNLM
OT  - antibody epitope repertoires
OT  - dietary antibodies
OT  - nutrition
OT  - nutritional immunology
OT  - phage display
COIS- Declaration of interests The authors declare no competing interests.
EDAT- 2022/12/07 06:00
MHDA- 2022/12/17 06:00
CRDT- 2022/12/06 18:42
PHST- 2021/12/07 00:00 [received]
PHST- 2022/06/01 00:00 [revised]
PHST- 2022/11/09 00:00 [accepted]
PHST- 2022/12/07 06:00 [pubmed]
PHST- 2022/12/17 06:00 [medline]
PHST- 2022/12/06 18:42 [entrez]
AID - S1074-7613(22)00594-5 [pii]
AID - 10.1016/j.immuni.2022.11.004 [doi]
PST - ppublish
SO  - Immunity. 2022 Dec 13;55(12):2454-2469.e6. doi: 10.1016/j.immuni.2022.11.004. 
      Epub 2022 Dec 5.