PMID- 36474629
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221207
IS  - 2516-5410 (Electronic)
IS  - 2096-6938 (Print)
IS  - 2516-5410 (Linking)
VI  - 5
IP  - 1
DP  - 2022
TI  - Prognostic factors in children with acute fulminant myocarditis receiving 
      venoarterial extracorporeal membrane oxygenation.
PG  - e000271
LID - 10.1136/wjps-2021-000271 [doi]
LID - e000271
AB  - BACKGROUND: Pediatric acute fulminant myocarditis (AFM) is a very dangerous 
      disease that may lead to acute heart failure or even sudden death. Previous 
      reports have identified some prognostic factors in adult AFM; however, there is 
      no such research on children with AFM on venoarterial extracorporeal membrane 
      oxygenation (VA-ECMO). This study aimed to find relevant prognostic factors for 
      predicting adverse clinical outcomes. METHODS: A retrospective analysis was 
      performed in an affiliated university children's hospital with consecutive 
      patients receiving VA-ECMO for AFM from July 2010 to November 2020. These 
      children were classified into a survivor group (n=33) and a non-survivor group 
      (n=8). Patient demographics, clinical events, laboratory findings, and 
      electrocardiographic and echocardiographic parameters were analyzed. RESULTS: 
      Peak serum creatinine (SCr) and peak creatine kinase isoenzyme MB during ECMO had 
      joint predictive value for in-hospital mortality (p=0.011, AUC=0.962). Based on 
      multivariable logistic regression analysis, peak SCr level during ECMO support 
      was an independent predictor of in-hospital mortality (OR=1.035, 95% CI 1.006 to 
      1.064, p=0.017, AUC=0.936, with optimal cut-off value of 78 mumol/L). CONCLUSION: 
      Tissue hypoperfusion and consequent end-organ damage ultimately hampered the 
      outcomes. The need for left atrial decompression indicated a sicker patient on 
      ECMO and introduced additional risk for complications. Earlier and more cautious 
      deployment would likely be associated with decreased risk of complications and 
      mortality.
CI  - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Sun, Mingwei
AU  - Sun M
AUID- ORCID: 0000-0002-1459-0043
AD  - CPB/ECMO, Zhejiang University School of Medicine Children's Hospital, Hangzhou, 
      Zhejiang, China.
FAU - Zong, Qing
AU  - Zong Q
AD  - CPB/ECMO, Zhejiang University School of Medicine Children's Hospital, Hangzhou, 
      Zhejiang, China.
FAU - Ye, Li Fen
AU  - Ye LF
AD  - CPB/ECMO, Zhejiang University School of Medicine Children's Hospital, Hangzhou, 
      Zhejiang, China.
FAU - Fan, Yong
AU  - Fan Y
AD  - CPB/ECMO, Zhejiang University School of Medicine Children's Hospital, Hangzhou, 
      Zhejiang, China.
FAU - Yang, Lijun
AU  - Yang L
AD  - CPB/ECMO, Zhejiang University School of Medicine Children's Hospital, Hangzhou, 
      Zhejiang, China.
FAU - Lin, Ru
AU  - Lin R
AUID- ORCID: 0000-0001-8319-4995
AD  - CPB/ECMO, Zhejiang University School of Medicine Children's Hospital, Hangzhou, 
      Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20220106
PL  - England
TA  - World J Pediatr Surg
JT  - World journal of pediatric surgery
JID - 101761337
PMC - PMC9717374
OTO - NOTNLM
OT  - cardiology
OT  - cardiovascular system
OT  - extracorporeal membrane oxygenation
OT  - pediatrics
COIS- Competing interests: None declared.
EDAT- 2022/12/08 06:00
MHDA- 2022/12/08 06:01
PMCR- 2022/01/06
CRDT- 2022/12/07 02:06
PHST- 2021/01/27 00:00 [received]
PHST- 2021/08/24 00:00 [accepted]
PHST- 2022/12/07 02:06 [entrez]
PHST- 2022/12/08 06:00 [pubmed]
PHST- 2022/12/08 06:01 [medline]
PHST- 2022/01/06 00:00 [pmc-release]
AID - wjps-2021-000271 [pii]
AID - 10.1136/wjps-2021-000271 [doi]
PST - epublish
SO  - World J Pediatr Surg. 2022 Jan 6;5(1):e000271. doi: 10.1136/wjps-2021-000271. 
      eCollection 2022.