PMID- 36476214
OWN - NLM
STAT- MEDLINE
DCOM- 20221222
LR  - 20221222
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Dec 7
TI  - Comparison of the red blood cell indices based on accuracy, sensitivity, and 
      specificity to predict one-year mortality in heart failure patients.
PG  - 532
LID - 10.1186/s12872-022-02987-x [doi]
LID - 532
AB  - BACKGROUND: Various investigations have specified the role of each RBC indices 
      separately [including hemoglobin (Hb), hematocrit (HCT), mean corpuscular 
      volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin 
      concentration (MCHC), and red blood cell distribution width (RDW)] to predict the 
      prognosis of acute heart failure (AHF) patients. However, in the current study, 
      these variables were compared based on accuracy, sensitivity, and specificity to 
      determine the best prognostic factor. METHODS: Of 734 heart failure patients 
      referred to the emergency department, 400 cases were enrolled based on the 
      inclusion and exclusion criteria. Data of them were documented, and patients were 
      followed for one year. Eventually, the association of clinical variables and RBC 
      indices with one-year mortality was explored. RESULTS: The study included 226 
      (56%) men and 174 (44%) women with a median age of 66 years. Body Mass Index (HR 
      1.098, p = 0.016), Hb (HR 0.728, p = 0.024), HTC (HR 0.875, p = 0.066), MCHC (HR 
      0.795, p = 0.037), and RDW-CV (HR 1.174, p = 0.006) were confirmed as predictors 
      of long-term mortality. Despite confirming the predictive role of these variables 
      by ROC curves, their sensitivity and specificity were reported as follows: [72% 
      and 50% for Hb], [75% and 52% for  HCT], [88% and 27% for MCHC], and [49% and 81% 
      for RDW]. In addition, stratified groups of patients, based on normal cut-off 
      values obtained from scientific literature, had significantly different survival 
      in Kaplan-Meier analyses. CONCLUSION: Whilst proving the predictive role of Hb, 
       HCT, MCHC, and RDW in AHF patients, the most sensitive measurement was MCHC and 
      the most specific one was RDW; therefore, these variables should be considered 
      for risk stratification purposes of AHF patients in daily clinical practice.
CI  - (c) 2022. The Author(s).
FAU - Hosseinpour, Morteza
AU  - Hosseinpour M
AD  - Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Hatamnejad, Mohammad Reza
AU  - Hatamnejad MR
AD  - Department of Cardiology, Shiraz University of Medical Sciences, and Zand St, PO 
      Box: 71348-14336, Shiraz, Iran. Hatamnejad.MD@gmail.com.
FAU - Montazeri, Mohammad Nima
AU  - Montazeri MN
AD  - Faculty of Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, 
      Russia.
FAU - Bazrafshan Drissi, Hamed
AU  - Bazrafshan Drissi H
AD  - Department of Cardiology, Shiraz University of Medical Sciences, and Zand St, PO 
      Box: 71348-14336, Shiraz, Iran. Hamedbazrafshan@yahoo.com.
FAU - Akbari Khezrabadi, Ali
AU  - Akbari Khezrabadi A
AD  - Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Shojaeefard, Ehsan
AU  - Shojaeefard E
AD  - Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
FAU - Khanzadeh, Shokoufeh
AU  - Khanzadeh S
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20221207
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - *Erythrocyte Indices
MH  - Erythrocytes
MH  - *Heart Failure/diagnosis
PMC - PMC9727904
OTO - NOTNLM
OT  - Anemia
OT  - Erythrocyte indices
OT  - Heart failure
OT  - Hematocrit
OT  - Mean corpuscular hemoglobin
OT  - Mean corpuscular hemoglobin concentration
OT  - Mean corpuscular volume
OT  - Red cell distribution width
COIS- The authors confirm that there are no known conflicts of interest associated with 
      this publication.
EDAT- 2022/12/09 06:00
MHDA- 2022/12/15 06:00
PMCR- 2022/12/07
CRDT- 2022/12/08 10:09
PHST- 2022/01/31 00:00 [received]
PHST- 2022/11/30 00:00 [accepted]
PHST- 2022/12/08 10:09 [entrez]
PHST- 2022/12/09 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/12/07 00:00 [pmc-release]
AID - 10.1186/s12872-022-02987-x [pii]
AID - 2987 [pii]
AID - 10.1186/s12872-022-02987-x [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2022 Dec 7;22(1):532. doi: 10.1186/s12872-022-02987-x.