PMID- 36479063
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221210
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 12
DP  - 2022
TI  - Correlative factors of ocular surface lesions after allogeneic hematopoietic stem 
      cell transplantation: A retrospective study.
PG  - 1040679
LID - 10.3389/fonc.2022.1040679 [doi]
LID - 1040679
AB  - BACKGROUND: Ocular graft-versus-host disease (oGVHD) is one of the complications 
      after allogeneic hematopoietic stem cell transplantation (HSCT), which impairs 
      the quality of life and may indicate poor prognosis. In this retrospective study, 
      the aim was to investigate the characteristics of ocular surface after HSCT, and 
      analyze the risk factors related to the severity of ocular surface lesions. 
      METHODS: 248 post-HSCT patients were enrolled in this retrospective study. 
      Subjects were divided into no lesion group, mild lesion group and severe lesion 
      group, according to the severity of ocular surface lesions. The correlations 
      between grades of ocular surface lesions and gender, age, primary disease, donor 
      source, human leukocyte antigen (HLA) type, kinship, donor-recipient 
      relationship, blood type, source of stem cell and systemic GVHD were analyzed. 
      RESULTS: The median scores of corneal epitheliopathy, lid margin lesions and 
      meibomian gland loss were 3, 6 and 2 points, respectively. The grade of corneal 
      epitheliopathy was related to donor source (P<0.001), kinship (P=0.033), 
      HLA-matching (P<0.001), and systemic GVHD (P=0.007), especially oral GVHD 
      (P<0.001) and liver GVHD (P=0.002). The grade of lid margin lesions was related 
      to donor source (P=0.019), HLA-matching (P=0.006), and systemic GVHD (P=0.013), 
      especially skin GVHD (P=0.019) and oral GVHD (P=0.019). The grade of meibomian 
      gland loss was related to age (P=0.035) and gastrointestinal GVHD (P=0.007). The 
      grade of corneal epitheliopathy after HSCT was related to the lid margin lesion 
      score (P<0.001). CONCLUSIONS: The occurrence and development of ocular GVHD are 
      mostly accompanied by the history of systemic GVHD. While in few cases, ocular 
      surface lesions related to GVHD can be observed prior to the rejection of other 
      tissues and organs. Severe corneal epitheliopathy occurs in patients with severe 
      lid margin lesions in ocular GVHD. The lesions of corneal epithelium and lid 
      margin are milder in HLA partially matching transplantation.
CI  - Copyright (c) 2022 Zhuang, Sun, Xu, Ren, Chen, Chen, Ma, Tang and Zhang.
FAU - Zhuang, Xin-Yu
AU  - Zhuang XY
AD  - Department of Ophthalmology, First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Sun, Zheng-Tai
AU  - Sun ZT
AD  - Department of Ophthalmology, First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Xu, Yue
AU  - Xu Y
AD  - Department of Ophthalmology, Dushu Lake Hospital Affiliated to Soochow 
      University, Suzhou, China.
FAU - Ren, Ya-Ru
AU  - Ren YR
AD  - Department of Ophthalmology, First Affiliated Hospital of Soochow University, 
      Suzhou, China.
FAU - Chen, Ying-Jie
AU  - Chen YJ
AD  - Department of Ophthalmology, Dushu Lake Hospital Affiliated to Soochow 
      University, Suzhou, China.
FAU - Chen, Feng
AU  - Chen F
AD  - National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of 
      Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
AD  - Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of 
      Hematology, Soochow University, Suzhou, China.
FAU - Ma, Xiao
AU  - Ma X
AD  - National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of 
      Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
AD  - Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of 
      Hematology, Soochow University, Suzhou, China.
FAU - Tang, Xiao-Wen
AU  - Tang XW
AD  - National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of 
      Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
AD  - Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of 
      Hematology, Soochow University, Suzhou, China.
FAU - Zhang, Xiao-Feng
AU  - Zhang XF
AD  - Department of Ophthalmology, First Affiliated Hospital of Soochow University, 
      Suzhou, China.
AD  - Department of Ophthalmology, Dushu Lake Hospital Affiliated to Soochow 
      University, Suzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20221121
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC9719980
OTO - NOTNLM
OT  - allogeneic hematopoietic stem cell transplantation
OT  - graft-versus-host disease (GVHD)
OT  - keratoconjunctivitis sicca (KCS)
OT  - ocular
OT  - ocular surface
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/09 06:00
MHDA- 2022/12/09 06:01
PMCR- 2022/01/01
CRDT- 2022/12/08 13:54
PHST- 2022/09/09 00:00 [received]
PHST- 2022/11/07 00:00 [accepted]
PHST- 2022/12/08 13:54 [entrez]
PHST- 2022/12/09 06:00 [pubmed]
PHST- 2022/12/09 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2022.1040679 [doi]
PST - epublish
SO  - Front Oncol. 2022 Nov 21;12:1040679. doi: 10.3389/fonc.2022.1040679. eCollection 
      2022.