PMID- 36479293
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221210
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Meta-analysis of omega-3 polyunsaturated fatty acids on immune functions and 
      nutritional status of patients with colorectal cancer.
PG  - 945590
LID - 10.3389/fnut.2022.945590 [doi]
LID - 945590
AB  - This meta-analysis assessed the clinical significance of omega-3 polyunsaturated 
      fatty acids (PUFAs) in the management of patients with colorectal cancer (CRC) 
      after radical resection. We comprehensively searched electronic databases, such 
      as EMBASE, PubMed, MEDLINE and Cochrane Library, China National Knowledge 
      Infrastructure (CNKI), China Biomedical Database (CBM), Wanfang Electronic 
      Database, and VIP Medical Information System (VIP) from inception to 10 April 
      2022. Randomized controlled trials (RCTs) of omega-3 PUFAs and conventional 
      nutrition or blank treatments were selected. The following were evaluated in the 
      pooled analysis: immune function-related indices (IgA, IgG, IgM, CD3(+), CD4(+), 
      CD8(+), and ratio of CD4(+)/CD8(+)), nutritional status-related indices [total 
      protein (TP), albumin (ALB), and prealbumin (PA)], and their corresponding 95% 
      confidence intervals (CIs). Next, we conducted heterogeneity detection, 
      sensitivity analysis, contour-enhanced funnel plot to detect possible publication 
      bias, and meta-regression analysis. In all, 20 studies, including 1,613 patients 
      (809 in the omega-3 PUFAs group and 804 in the control group), were selected in 
      the final analysis. The results of the pooled analysis showed that omega-3 PUFAs 
      significantly increased the humoral immune function indices, including IgA 
      [standardized mean difference (SMD) = 0.54, 95% CI 0.10-0.99], IgM (SMD = 0.52, 
      95% CI 0.05-0.99), IgG (SMD = 0.65, 95% CI 0.47-0.84); T cell immune function 
      indices, including CD3(+) (SMD = 0.73, 95% CI 0.54-0.92), CD4(+) (SMD = 0.76, 95% 
      CI 0.53-0.98), and ratio of CD4(+)/CD8(+) (SMD = 0.66, 95% CI 0.39-0.92). 
      However, CD8(+) was markedly reduced after intervention of omega-3 PUFAs (SMD = 
      -0.28, 95% CI -0.66-0.09). In addition, pooled analysis indicated that omega-3 
      PUFAs markedly improved the nutritional status indicators, including TP (SMD = 
      0.53, 95% CI 0.17-0.88), ALB (SMD = 0.43, 95% CI 0.15-0.70), and PA (SMD = 0.46, 
      95% CI 0.01-0.90). The meta-regression analysis revealed that the covariates of 
      the small sample affected the robustness and credibility of the CD4(+) results. 
      Conclusively, this study suggested that omega-3 PUFAs have the potential to be 
      used as a valid immunonutritional therapy/support for treating patients with CRC 
      postoperatively. This meta-analysis protocol was registered in PROSPERO (no. 
      CRD42021288487). SYSTEMATIC REVIEW REGISTRATION: 
      [https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021288487], 
      identifier [CRD42021288487].
CI  - Copyright (c) 2022 Yue, Xiong, Deng, Hu, Tan, Li, Yang and Xiao.
FAU - Yue, Tinghui
AU  - Yue T
AD  - College of Clinical Medicine, Guizhou University of Traditional Chinese Medicine, 
      Guiyang, China.
FAU - Xiong, Kai
AU  - Xiong K
AD  - College of Clinical Medicine, Guizhou University of Traditional Chinese Medicine, 
      Guiyang, China.
AD  - Colorectal and Anal Surgery, First Affiliated Hospital of Guizhou University of 
      Traditional Chinese Medicine, Guiyang, China.
FAU - Deng, Jia
AU  - Deng J
AD  - College of Clinical Medicine, Guizhou University of Traditional Chinese Medicine, 
      Guiyang, China.
FAU - Hu, Wenting
AU  - Hu W
AD  - College of Clinical Medicine, Guizhou University of Traditional Chinese Medicine, 
      Guiyang, China.
FAU - Tan, Tianying
AU  - Tan T
AD  - College of Clinical Medicine, Guizhou University of Traditional Chinese Medicine, 
      Guiyang, China.
FAU - Li, Shuangshuang
AU  - Li S
AD  - College of Clinical Medicine, Guizhou University of Traditional Chinese Medicine, 
      Guiyang, China.
FAU - Yang, Tao
AU  - Yang T
AD  - Colorectal and Anal Surgery, First Affiliated Hospital of Guizhou University of 
      Traditional Chinese Medicine, Guiyang, China.
FAU - Xiao, Tianbao
AU  - Xiao T
AD  - Colorectal and Anal Surgery, First Affiliated Hospital of Guizhou University of 
      Traditional Chinese Medicine, Guiyang, China.
LA  - eng
PT  - Systematic Review
DEP - 20221121
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9719975
OTO - NOTNLM
OT  - T cell immunity
OT  - colorectal cancer
OT  - humoral immunity
OT  - meta-analysis
OT  - nutritional status
OT  - omega-3 polyunsaturated fatty acids
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/09 06:00
MHDA- 2022/12/09 06:01
PMCR- 2022/01/01
CRDT- 2022/12/08 14:02
PHST- 2022/05/16 00:00 [received]
PHST- 2022/10/31 00:00 [accepted]
PHST- 2022/12/08 14:02 [entrez]
PHST- 2022/12/09 06:00 [pubmed]
PHST- 2022/12/09 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.945590 [doi]
PST - epublish
SO  - Front Nutr. 2022 Nov 21;9:945590. doi: 10.3389/fnut.2022.945590. eCollection 
      2022.