PMID- 36479563
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221210
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Prognostic value of a left atrioventricular coupling index in pre- and 
      post-menopausal women from the Multi-Ethnic Study of Atherosclerosis.
PG  - 1066849
LID - 10.3389/fcvm.2022.1066849 [doi]
LID - 1066849
AB  - BACKGROUND: Sex hormones associated with both the left atrial (LA) and left 
      ventricular (LV) structures in women, but the association of menopause status 
      with left atrioventricular coupling is not established. AIM: To assess the 
      prognostic value of a left atrioventricular coupling index (LACI) in 
      peri-menopausal women without a history of cardiovascular disease (CVD). 
      MATERIALS AND METHODS: In all women participating in MESA study with baseline 
      cardiovascular MRI, the LACI was measured as the ratio of the LA end-diastolic 
      volume to the LV end-diastolic volume. Cox models were used to assess the 
      association between the LACI and the outcomes of atrial fibrillation (AF), heart 
      failure (HF), coronary heart disease (CHD) death, and hard CVD. RESULTS: Among 
      the 2,087 women participants (61 +/- 10 years), 485 cardiovascular events occurred 
      (mean follow-up: 13.2 +/- 3.3 years). A higher LACI was independently associated 
      with AF (HR 1.70; 95%CI [1.51-1.90]), HF (HR 1.62; [1.33-1.97]), CHD death (HR 
      1.36; [1.10-1.68]), and hard CVD (HR 1.30; [1.13-1.51], all p < 0.001). Adjusted 
      models with the LACI showed significant improvement in model discrimination and 
      reclassification when compared to traditional models to predict: incident AF 
      (C-statistic: 0.82 vs. 0.79; NRI = 0.325; IDI = 0.036), HF (C-statistic: 0.84 vs. 
      0.81; NRI = 0.571; IDI = 0.023), CHD death (C-statistic: 0.87 vs. 0.85; NRI = 
      0.506; IDI = 0.012), hard CVD (C-statistic: 0.78 vs. 0.76; NRI = 0.229; IDI = 
      0.012). The prognostic value of the LACI had a better discrimination and 
      reclassification than individual LA or LV parameters. CONCLUSION: In a 
      multi-ethnic population of pre- and post-menopausal women, the LACI is an 
      independent predictor of HF, AF, CHD death, and hard CVD. CLINICAL TRIAL 
      REGISTRATION: [https://clinicaltrials.gov/], identifier [NCT00005487].
CI  - Copyright (c) 2022 Pezel, Michos, Varadarajan, Shabani, Venkatesh, Vaidya, Kato, De 
      Vasconcellos, Heckbert, Wu, Post, Bluemke, Allison, Henry and Lima.
FAU - Pezel, Theo
AU  - Pezel T
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
AD  - Universite de Paris Cite, Service de Cardiologie, Hopital Universitaire 
      Lariboisiere - APHP, Paris, France.
FAU - Michos, Erin D
AU  - Michos ED
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
FAU - Varadarajan, Vinithra
AU  - Varadarajan V
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
FAU - Shabani, Mahsima
AU  - Shabani M
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
FAU - Venkatesh, Bharath Ambale
AU  - Venkatesh BA
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
FAU - Vaidya, Dhananjay
AU  - Vaidya D
AD  - Department of Medicine Division of General Medicine, The Johns Hopkins 
      University, Baltimore, MD, United States.
FAU - Kato, Yoko
AU  - Kato Y
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
FAU - De Vasconcellos, Henrique Doria
AU  - De Vasconcellos HD
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
FAU - Heckbert, Susan R
AU  - Heckbert SR
AD  - Department of Epidemiology, University of Washington, Seattle, WA, United States.
FAU - Wu, Colin O
AU  - Wu CO
AD  - Division of Intramural Research, National Heart Lung and Blood Institute, 
      Bethesda, MD, United States.
FAU - Post, Wendy S
AU  - Post WS
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
FAU - Bluemke, David A
AU  - Bluemke DA
AD  - Department of Radiology, University of Wisconsin School of Medicine and Public 
      Health, Madison, WI, United States.
FAU - Allison, Matthew A
AU  - Allison MA
AD  - Division of Preventive Medicine, Department of Family Medicine and Public Health, 
      University of California, San Diego, La Jolla, CA, United States.
FAU - Henry, Patrick
AU  - Henry P
AD  - Universite de Paris Cite, Service de Cardiologie, Hopital Universitaire 
      Lariboisiere - APHP, Paris, France.
FAU - Lima, Joao A C
AU  - Lima JAC
AD  - Division of Cardiology, Johns Hopkins University, Baltimore, MD, United States.
LA  - eng
SI  - ClinicalTrials.gov/NCT00005487
PT  - Journal Article
DEP - 20221121
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9719991
OTO - NOTNLM
OT  - Multi-Ethnic Study of Atherosclerosis (MESA)
OT  - cardiovascular events (CVE)
OT  - cardiovascular magnetic resonanace
OT  - left atrioventricular coupling
OT  - menopause
OT  - prognosis
OT  - sex hormones (SH)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/09 06:00
MHDA- 2022/12/09 06:01
PMCR- 2022/01/01
CRDT- 2022/12/08 14:09
PHST- 2022/10/11 00:00 [received]
PHST- 2022/11/02 00:00 [accepted]
PHST- 2022/12/08 14:09 [entrez]
PHST- 2022/12/09 06:00 [pubmed]
PHST- 2022/12/09 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.1066849 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2022 Nov 21;9:1066849. doi: 10.3389/fcvm.2022.1066849. 
      eCollection 2022.