PMID- 36480389
OWN - NLM
STAT- MEDLINE
DCOM- 20230522
LR  - 20230522
IS  - 1936-2293 (Electronic)
IS  - 1064-1297 (Linking)
VI  - 31
IP  - 3
DP  - 2023 Jun
TI  - Translational findings linking poor inhibitory control and heightened drug reward 
      sensitivity.
PG  - 575-583
LID - 10.1037/pha0000626 [doi]
AB  - Poor inhibitory control and heightened sensitivity to drug reward are two 
      well-established risk factors for substance use disorders. Although these risk 
      factors have traditionally been studied independently, there is reason to expect 
      they may be related at the neurobiological level. Here, translational studies 
      investigating the association between poor inhibition and greater drug reward 
      sensitivity in both laboratory animals and humans are reviewed. Findings show 
      that in animals, inhibitory deficits are associated with greater 
      self-administration of cocaine, nicotine, 3,4-methylenedioxy-methamphetamine 
      (MDMA), and alcohol, but not heroin. Likewise, in healthy human volunteers, poor 
      inhibitory control and less brain engagement in right frontal regions during 
      inhibition are associated with greater and more positive subjective responses to 
      amphetamine and alcohol. The potential neurobiological mechanisms underlying this 
      association are discussed, including the number or function of striatal dopamine 
      D(2) receptors, as well as the implications of the findings and directions for 
      future research. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
FAU - Weafer, Jessica
AU  - Weafer J
AUID- ORCID: 0000-0002-7849-9900
AD  - Department of Psychology, University of Kentucky.
LA  - eng
GR  - AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20221208
PL  - United States
TA  - Exp Clin Psychopharmacol
JT  - Experimental and clinical psychopharmacology
JID - 9419066
RN  - 0 (Pharmaceutical Preparations)
RN  - CK833KGX7E (Amphetamine)
RN  - 44RAL3456C (Methamphetamine)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Pharmaceutical Preparations
MH  - *Substance-Related Disorders
MH  - Amphetamine
MH  - *Methamphetamine
MH  - Ethanol
MH  - Reward
EDAT- 2022/12/09 06:00
MHDA- 2023/05/22 06:42
CRDT- 2022/12/08 15:06
PHST- 2023/05/22 06:42 [medline]
PHST- 2022/12/09 06:00 [pubmed]
PHST- 2022/12/08 15:06 [entrez]
AID - 2023-26196-001 [pii]
AID - 10.1037/pha0000626 [doi]
PST - ppublish
SO  - Exp Clin Psychopharmacol. 2023 Jun;31(3):575-583. doi: 10.1037/pha0000626. Epub 
      2022 Dec 8.