PMID- 36481112
OWN - NLM
STAT- MEDLINE
DCOM- 20230117
LR  - 20230216
IS  - 1557-3117 (Electronic)
IS  - 1053-2498 (Linking)
VI  - 42
IP  - 2
DP  - 2023 Feb
TI  - Cardiac output assessment methods in left ventricular assist device patients: A 
      problem of heteroscedasticity.
PG  - 145-149
LID - S1053-2498(22)02203-3 [pii]
LID - 10.1016/j.healun.2022.10.021 [doi]
AB  - Equipoise remains about how best to measure cardiac output (CO) in patients with 
      left ventricular assist devices (LVAD). In this study, direct Fick CO was 
      compared with thermodilution (TD) and indirect Fick (iFick) CO in 61 LVAD 
      patients. TD and LaFarge iFick showed moderate correlation with direct Fick 
      (R(2) = 0.49 and R(2) = 0.38, p < 0.001 for both), while Dehmer and Bergstra 
      iFick showed poor correlation with direct Fick (R(2) = 0.29 and R(2) = 0.31, p < 
      0.001 for both). Absolute bias between all CO estimation techniques and direct 
      Fick CO was lowest for TD compared to iFick methods but significant for all 
      methods. All methods tended to overestimate CO compared to direct Fick, with 
      greatest overestimation present in those with the lowest measured direct Fick CO. 
      Bias and frequency of significant discrepancy were least using TD and Lafarge 
      iFick CO estimation methods in this study, with TD CO demonstrating modestly 
      better correlation and less heteroscedasticity compared to Lafarge.
CI  - Copyright (c) 2022 International Society for Heart and Lung Transplantation. 
      Published by Elsevier Inc. All rights reserved.
FAU - Azih, Nnamdi I
AU  - Azih NI
AD  - Department of Medicine, Medical University of South Carolina, Charleston, South 
      Carolina.
FAU - Read, Jacob M
AU  - Read JM
AD  - Department of Medicine, Medical University of South Carolina, Charleston, South 
      Carolina.
FAU - Jackson, Gregory R
AU  - Jackson GR
AD  - Division of Cardiology, Department of Medicine, Medical University of South 
      Carolina, Charleston, South Carolina.
FAU - Inampudi, Chak
AU  - Inampudi C
AD  - Division of Cardiology, Department of Medicine, Medical University of South 
      Carolina, Charleston, South Carolina.
FAU - Witer, Lucas
AU  - Witer L
AD  - Division of Cardiothoracic Surgery, Department of Surgery, Medical University of 
      South Carolina, Charleston, South Carolina.
FAU - Kilic, Arman
AU  - Kilic A
AD  - Division of Cardiothoracic Surgery, Department of Surgery, Medical University of 
      South Carolina, Charleston, South Carolina.
FAU - Pope, Nicholas H
AU  - Pope NH
AD  - Division of Cardiothoracic Surgery, Department of Surgery, Medical University of 
      South Carolina, Charleston, South Carolina.
FAU - Hajj, Jennifer
AU  - Hajj J
AD  - Division of Cardiology, Department of Medicine, Medical University of South 
      Carolina, Charleston, South Carolina.
FAU - Haddad, Francois
AU  - Haddad F
AD  - Division of Cardiovascular Medicine, Stanford University School of Medicine, 
      Stanford, California.
FAU - Tedford, Ryan J
AU  - Tedford RJ
AD  - Division of Cardiology, Department of Medicine, Medical University of South 
      Carolina, Charleston, South Carolina.
FAU - Houston, Brian A
AU  - Houston BA
AD  - Division of Cardiology, Department of Medicine, Medical University of South 
      Carolina, Charleston, South Carolina. Electronic address: houstobr@musc.edu.
LA  - eng
PT  - Journal Article
DEP - 20221118
PL  - United States
TA  - J Heart Lung Transplant
JT  - The Journal of heart and lung transplantation : the official publication of the 
      International Society for Heart Transplantation
JID - 9102703
SB  - IM
MH  - Humans
MH  - *Heart-Assist Devices
MH  - Cardiac Output
MH  - Thermodilution/methods
MH  - Oxygen Consumption
MH  - Monitoring, Physiologic
OTO - NOTNLM
OT  - LVAD
OT  - cardiac output
OT  - hemodynamics
COIS- Conflicts of interest statement The authors report no relationships that could be 
      construed as a conflict of interest.
EDAT- 2022/12/09 06:00
MHDA- 2023/01/18 06:00
CRDT- 2022/12/08 23:22
PHST- 2022/07/17 00:00 [received]
PHST- 2022/10/06 00:00 [revised]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2022/12/09 06:00 [pubmed]
PHST- 2023/01/18 06:00 [medline]
PHST- 2022/12/08 23:22 [entrez]
AID - S1053-2498(22)02203-3 [pii]
AID - 10.1016/j.healun.2022.10.021 [doi]
PST - ppublish
SO  - J Heart Lung Transplant. 2023 Feb;42(2):145-149. doi: 
      10.1016/j.healun.2022.10.021. Epub 2022 Nov 18.