PMID- 36481651
OWN - NLM
STAT- MEDLINE
DCOM- 20230123
LR  - 20230123
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 241
DP  - 2023 Jan
TI  - Mucoepidermoid carcinoma of the esophagus with MAML2 gene rearrangement: Case 
      report and literature review.
PG  - 154242
LID - S0344-0338(22)00486-1 [pii]
LID - 10.1016/j.prp.2022.154242 [doi]
AB  - Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy but 
      rarely occurs in the esophagus. It is easily confused with adenosquamous 
      carcinoma and squamous cell carcinoma (SCC) with mucus-secreting components. 
      MAML2 gene rearrangement detected by fluorescence in situ hybridization (FISH), 
      RT-PCR or next-generation sequencing (NGS) can aid in the diagnosis. We present a 
      case of esophageal MEC with MAML2 gene rearrangement detected by FISH. To the 
      best of our knowledge, this is the first report of an esophageal MEC with MAML2 
      gene rearrangement. We also reveal that esophageal MEC patients were reported to 
      have a higher risk of recurrence and death than SCC patients in previous 
      literature. However, all the cases were diagnosed using previous diagnostic 
      criteria and not confirmed by MAML2 gene rearrangement detection, and most of 
      them might not be true MECs.
CI  - Copyright (c) 2022 Elsevier GmbH. All rights reserved.
FAU - Chen, Rongshan
AU  - Chen R
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100021, China.
FAU - Wang, Bingzhi
AU  - Wang B
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100021, China.
FAU - Li, Lin
AU  - Li L
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100021, China.
FAU - Xue, Liyan
AU  - Xue L
AD  - Department of Pathology, National Cancer Center/National Clinical Research Center 
      for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Beijing 100021, China; Center for Cancer Precision Medicine, 
      Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical 
      College, Beijing 100021, China. Electronic address: xuely@cicams.ac.cn.
LA  - eng
PT  - Case Reports
PT  - Review
DEP - 20221202
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (MAML2 protein, human)
SB  - IM
MH  - Humans
MH  - DNA-Binding Proteins/genetics
MH  - Trans-Activators/genetics
MH  - *Carcinoma, Mucoepidermoid/pathology
MH  - In Situ Hybridization, Fluorescence
MH  - Nuclear Proteins/genetics
MH  - Transcription Factors/genetics
MH  - Gene Rearrangement
MH  - *Salivary Gland Neoplasms/pathology
MH  - *Carcinoma, Squamous Cell/genetics
MH  - Esophagus/pathology
OTO - NOTNLM
OT  - Esophagus
OT  - MAML2
OT  - Mucoepidermoid carcinoma
COIS- Declaration of Competing Interest The authors declare that they have no conflict 
      of interest regarding this article. All the authors listed have approved the 
      present submitted version.
EDAT- 2022/12/09 06:00
MHDA- 2023/01/24 06:00
CRDT- 2022/12/08 23:51
PHST- 2022/06/06 00:00 [received]
PHST- 2022/11/17 00:00 [revised]
PHST- 2022/11/23 00:00 [accepted]
PHST- 2022/12/09 06:00 [pubmed]
PHST- 2023/01/24 06:00 [medline]
PHST- 2022/12/08 23:51 [entrez]
AID - S0344-0338(22)00486-1 [pii]
AID - 10.1016/j.prp.2022.154242 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2023 Jan;241:154242. doi: 10.1016/j.prp.2022.154242. Epub 2022 
      Dec 2.