PMID- 36481900
OWN - NLM
STAT- MEDLINE
DCOM- 20221215
LR  - 20230304
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 2560
DP  - 2023
TI  - Large Animal Models of Retinitis Pigmentosa in Therapy Development and 
      Preclinical Testing.
PG  - 233-248
LID - 10.1007/978-1-0716-2651-1_22 [doi]
AB  - Large animal models are valuable for developing and testing translational 
      therapies for inherited retinal dystrophies such as retinitis pigmentosa (RP). 
      Gene augmentation therapy has been developed utilizing such models. 
      Adeno-associated viral (AAV) vectors have been frequently utilized and delivered 
      by intravitreal or subretinal injection. In vivo longitudinal assessments of 
      therapeutic outcomes are essential. These include regular ophthalmic examinations 
      as well as detailed fundus assessments including confocal scanning laser 
      ophthalmoscopy (cSLO) and high-resolution cross-sectional imaging of the retina 
      by spectral domain-optical coherence tomography (SD-OCT). Retinal function 
      assessment includes vision testing and electroretinography (ERG).
CI  - (c) 2023. The Author(s), under exclusive license to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Occelli, Laurence M
AU  - Occelli LM
AD  - Department of Small Animal Clinical Studies, College of Veterinary Medicine, 
      Michigan State University, East Lansing, MI, USA.
FAU - Petersen-Jones, Simon M
AU  - Petersen-Jones SM
AD  - Department of Small Animal Clinical Studies, College of Veterinary Medicine, 
      Michigan State University, East Lansing, MI, USA. peter315@msu.edu.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Animals
MH  - *Retinitis Pigmentosa/genetics/therapy
MH  - Models, Animal
OTO - NOTNLM
OT  - In vivo assessment techniques
OT  - Large animal model
OT  - Retinitis pigmentosa
OT  - Therapy
EDAT- 2022/12/10 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/12/09 00:23
PHST- 2022/12/09 00:23 [entrez]
PHST- 2022/12/10 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
AID - 10.1007/978-1-0716-2651-1_22 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2023;2560:233-248. doi: 10.1007/978-1-0716-2651-1_22.