PMID- 36482911
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221210
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 9
DP  - 2022
TI  - Lower insulin level is associated with sarcopenia in community-dwelling frail and 
      non-frail older adults.
PG  - 971622
LID - 10.3389/fmed.2022.971622 [doi]
LID - 971622
AB  - BACKGROUND: Sarcopenia is common among older individuals with and without type 2 
      diabetes mellitus (T2DM). There are conflicting evidence in support of the role 
      of insulin in the development of age-related and T2DM-related sarcopenia. We 
      investigated the relationships between the levels of fasting insulin and other 
      blood biomarkers related to insulin or lipid metabolism with the presence of 
      sarcopenia in two independent studies. MATERIALS AND METHODS: In 246 pre-frail 
      frail older individuals with (n = 41) and without T2DM (n = 205) in the Singapore 
      Frailty Interventional Trial, sarcopenia was defined by low appendicular lean 
      mass (ALM) relative to total body mass (skeletal muscle index, SMI = 
      ALM/height(2)) and low lower limb strength or gait speed according to the Asian 
      Working Group for Sarcopenia (AWGS) criteria released in 2019, and related to 
      levels of fasting insulin and glucose, C-peptide, IGF-1, leptin, and active 
      ghrelin. This investigation was validated in another independent study sample of 
      189 robust and pre-frail frail elderly in the Singapore Longitudinal Aging Study 
      Wave 2 (SLAS-2). RESULTS: Compared to non-sarcopenic individuals, those with 
      sarcopenia and possible sarcopenia showed significantly lower fasting insulin (p 
      < 0.05) in pre-frail/frail and non-frail older individuals. Consistent trends of 
      relationships were observed for serum levels of C-peptide, IGF-1, leptin, and 
      active ghrelin. In multivariable logistic regression models, sarcopenia was 
      independently associated with low insulin (p < 0.05). Levels of fasting insulin, 
      C-peptide, and leptin were also significantly associated with BMI, SMI, knee 
      extension strength, gait speed, and physical activity score. CONCLUSION: 
      Dysregulated insulin secretion in diabetic and non-diabetic older individuals may 
      play an important role in age-related and diabetes-related sarcopenia.
CI  - Copyright (c) 2022 Lu, Lim, Jin, Zin Nyunt, Fulop, Gao, Lim, Larbi and Ng.
FAU - Lu, Yanxia
AU  - Lu Y
AD  - Department of Medical Psychology and Ethics, School of Basic Medical Sciences, 
      Cheeloo College of Medicine, Shandong University, Jinan, China.
FAU - Lim, Wee Shiong
AU  - Lim WS
AD  - Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
AD  - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 
      Singapore.
FAU - Jin, Xia
AU  - Jin X
AD  - The Third Hospital of Jinan, Jinan, China.
FAU - Zin Nyunt, Ma Schwe
AU  - Zin Nyunt MS
AD  - Gerontology Research Programme, Department of Psychological Medicine, National 
      University Health System, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - Fulop, Tamas
AU  - Fulop T
AD  - Department of Medicine, Research Center on Aging, University of Sherbrooke, 
      Sherbrooke, QC, Canada.
FAU - Gao, Qi
AU  - Gao Q
AD  - Gerontology Research Programme, Department of Psychological Medicine, National 
      University Health System, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
FAU - Lim, Su Chi
AU  - Lim SC
AD  - Department of Endocrinology, Khoo Teck Puat Hospital, Singapore, Singapore.
FAU - Larbi, Anis
AU  - Larbi A
AD  - Department of Medicine, Research Center on Aging, University of Sherbrooke, 
      Sherbrooke, QC, Canada.
AD  - Biology of Ageing Laboratory, Singapore Immunology Network (SIgN), Agency for 
      Science Technology and Research (ASTAR), Biopolis, Singapore, Singapore.
FAU - Ng, Tze Pin
AU  - Ng TP
AD  - Gerontology Research Programme, Department of Psychological Medicine, National 
      University Health System, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20221122
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC9722960
OTO - NOTNLM
OT  - aging
OT  - diabetes
OT  - frailty
OT  - insulin
OT  - sarcopenia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/12/10 06:00
MHDA- 2022/12/10 06:01
PMCR- 2022/11/22
CRDT- 2022/12/09 03:49
PHST- 2022/06/17 00:00 [received]
PHST- 2022/11/07 00:00 [accepted]
PHST- 2022/12/09 03:49 [entrez]
PHST- 2022/12/10 06:00 [pubmed]
PHST- 2022/12/10 06:01 [medline]
PHST- 2022/11/22 00:00 [pmc-release]
AID - 10.3389/fmed.2022.971622 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2022 Nov 22;9:971622. doi: 10.3389/fmed.2022.971622. 
      eCollection 2022.