PMID- 36493676
OWN - NLM
STAT- MEDLINE
DCOM- 20230207
LR  - 20230227
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 248
DP  - 2023 Mar
TI  - Associations of metal mixtures in the meconium with birth outcomes in northern 
      Taiwan.
PG  - 114092
LID - S1438-4639(22)00175-4 [pii]
LID - 10.1016/j.ijheh.2022.114092 [doi]
AB  - Previous studies investigated prenatal exposure to neurotoxic metals in relation 
      to birth anthropometrics. However, limited information has been developed on 
      associations with birth outcomes of fetal exposure to metal mixtures using the 
      meconium as a biomarker. The purpose of this study was to evaluate relationships 
      of the combined effects of mercury (Hg), lead (Pb), cadmium (Cd), and arsenic 
      (As) concentrations in the meconium on birth outcomes (i.e., birth weight, birth 
      length, and head circumference). This cross-sectional study was conducted in 
      northern Taiwan between January 2007 and December 2009. We collected 526 meconium 
      samples within the first 24 h after birth to measure the in utero mixed-metal 
      exposure determined using inductively coupled plasma/mass spectrometry (ICP-MS). 
      We used a multivariable regression and Bayesian kernel machine regression (BKMR) 
      to estimate associations of the combined effects and identify important mixture 
      components with growth impairments. Our results revealed Hg, Pb, Cd, and As 
      concentrations in the meconium and enhanced the quantity of research on meconium 
      analyses. The overall effects of Hg, Pb, Cd, and As concentrations in the 
      meconium as prenatal exposure biomarkers were negatively associated with birth 
      growth. Fetal exposure to Hg and Pb was correlated with decreased birth weights. 
      Hg and Pb concentrations in the meconium were linearly inversely related to the 
      birth weight, birth length, and head circumference. Effects of fetal exposure to 
      As and Cd on birth outcomes were not obvious. A significant increasing 
      relationship was detected between Hg concentrations in the meconium and maternal 
      fish consumption during pregnancy. Higher Pb concentrations in the meconium were 
      observed among infants of mothers who consumed Chinese herbal medicines. Reducing 
      maternal fish consumption and Chinese herbal medicine consumption during 
      pregnancy could limit infant exposure to metals.
CI  - Copyright (c) 2022 Elsevier GmbH. All rights reserved.
FAU - Kao, Chi-Sian
AU  - Kao CS
AD  - School of Public Health, College of Public Health, Taipei Medical University, 
      Taipei, Taiwan.
FAU - Chien, Ling-Chu
AU  - Chien LC
AD  - School of Public Health, College of Public Health, Taipei Medical University, 
      Taipei, Taiwan; Neuroscience Research Center, Taipei Medical University, Taipei, 
      Taiwan; Nutrition Research Center, Taipei Medical University Hospital, Taipei, 
      Taiwan.
FAU - Fan, Chun-Hua
AU  - Fan CH
AD  - School of Public Health, College of Public Health, Taipei Medical University, 
      Taipei, Taiwan.
FAU - Lee, Hung-Chang
AU  - Lee HC
AD  - Department of Pediatric Gastroenterology, Hepatology and Nutrition, MacKay 
      Children's Hospital, Taipei, Taiwan.
FAU - Jiang, Chuen-Bin
AU  - Jiang CB
AD  - Department of Pediatric Gastroenterology, Hepatology and Nutrition, MacKay 
      Children's Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical 
      College, New Taipei City, Taiwan. Electronic address: a.4515@mmh.org.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20221206
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 00BH33GNGH (Cadmium)
RN  - 2P299V784P (Lead)
RN  - N712M78A8G (Arsenic)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Pregnancy
MH  - Humans
MH  - Female
MH  - Animals
MH  - Infant, Newborn
MH  - Cadmium/analysis
MH  - *Prenatal Exposure Delayed Effects/epidemiology
MH  - Birth Weight
MH  - Meconium/chemistry
MH  - Taiwan/epidemiology
MH  - Cross-Sectional Studies
MH  - Bayes Theorem
MH  - Lead/analysis
MH  - *Arsenic/analysis
MH  - *Mercury/analysis
MH  - Maternal Exposure
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Birth outcome
OT  - Fetal exposure
OT  - Meconium
OT  - Metal mixture
COIS- Declaration of competing interest The authors declare no conflicts of interest.
EDAT- 2022/12/10 06:00
MHDA- 2023/02/08 06:00
CRDT- 2022/12/09 18:27
PHST- 2022/07/21 00:00 [received]
PHST- 2022/12/01 00:00 [revised]
PHST- 2022/12/01 00:00 [accepted]
PHST- 2022/12/10 06:00 [pubmed]
PHST- 2023/02/08 06:00 [medline]
PHST- 2022/12/09 18:27 [entrez]
AID - S1438-4639(22)00175-4 [pii]
AID - 10.1016/j.ijheh.2022.114092 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2023 Mar;248:114092. doi: 10.1016/j.ijheh.2022.114092. 
      Epub 2022 Dec 6.