PMID- 36495230
OWN - NLM
STAT- MEDLINE
DCOM- 20230517
LR  - 20230517
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 161
IP  - 3
DP  - 2023 Jun
TI  - Influence of pre-eclampsia on 2-year neurodevelopmental outcome of 
      very-low-birth-weight infants.
PG  - 979-988
LID - 10.1002/ijgo.14614 [doi]
AB  - OBJECTIVE: To evaluate the influence of maternal pre-eclampsia on 
      neurodevelopmental outcome in very-low-birth-weight (VLBW) infants at 6, 12, and 
      24 months of corrected age. METHODS: We conducted a retrospective cohort study of 
      singleton VLBW infants between 2011 and 2018. The participants were divided into 
      three groups: (1) mothers without pre-eclampsia, (2) pre-eclampsia without severe 
      features, and (3) pre-eclampsia with severe features. The Bayley Scales of Infant 
      Development third edition (BSID-III) was used to assess the neurodevelopment of 
      participants. A BSID-III score < 85 was defined as neurodevelopmental impairment 
      (NDI). RESULTS: Overall, 482 VLBW infants born to 482 mothers were enrolled, of 
      whom 327 mothers did not have pre-eclampsia and 155 mothers had pre-eclampsia (58 
      without and 97 with severe features). The infants born to mothers with 
      pre-eclampsia with severe features had the lowest BSID-III scores at 6, 12, and 
      24 months. After adjustments, maternal pre-eclampsia with severe features was 
      significantly associated with cognitive NDI in their infants (adjusted odds ratio 
      [aOR] 4.14) and language NDI (aOR 3.37) at 2 years of corrected age. CONCLUSIONS: 
      VLBW fetuses born to mothers with pre-eclampsia with severe features have poorer 
      2-year neurodevelopmental outcome, which mainly manifests in the cognitive and 
      language domains.
CI  - (c) 2022 International Federation of Gynecology and Obstetrics.
FAU - Chang, Hao-Yang
AU  - Chang HY
AD  - Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, 
      Taiwan.
FAU - Chen, Chie-Pein
AU  - Chen CP
AD  - Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, 
      Taiwan.
FAU - Sun, Fang-Ju
AU  - Sun FJ
AD  - Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
FAU - Chen, Chen-Yu
AU  - Chen CY
AUID- ORCID: 0000-0003-4519-8391
AD  - Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, 
      Taiwan.
AD  - Department of Medicine, MacKay Medical College, New Taipei City, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20221223
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the 
      International Federation of Gynaecology and Obstetrics
JID - 0210174
SB  - IM
MH  - Infant, Newborn
MH  - Infant
MH  - Child
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Retrospective Studies
MH  - *Pre-Eclampsia/epidemiology
MH  - Infant, Very Low Birth Weight
OTO - NOTNLM
OT  - Bayley scales of infant development third edition
OT  - neurodevelopmental impairment
OT  - pre-eclampsia
OT  - very low birth weight
EDAT- 2022/12/11 06:00
MHDA- 2023/05/17 06:42
CRDT- 2022/12/10 08:12
PHST- 2022/11/02 00:00 [revised]
PHST- 2022/04/04 00:00 [received]
PHST- 2022/12/12 00:00 [accepted]
PHST- 2023/05/17 06:42 [medline]
PHST- 2022/12/11 06:00 [pubmed]
PHST- 2022/12/10 08:12 [entrez]
AID - 10.1002/ijgo.14614 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2023 Jun;161(3):979-988. doi: 10.1002/ijgo.14614. Epub 
      2022 Dec 23.